PMID- 34349619
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240403
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 15
DP  - 2021
TI  - Using Perfusion Contrast for Spatial Normalization of ASL MRI Images in a 
      Pediatric Craniosynostosis Population.
PG  - 698007
LID - 10.3389/fnins.2021.698007 [doi]
LID - 698007
AB  - Spatial normalization is an important step for group image processing and 
      evaluation of mean brain perfusion in anatomical regions using arterial spin 
      labeling (ASL) MRI and is typically performed via high-resolution structural 
      brain scans. However, structural segmentation and/or spatial normalization to 
      standard space is complicated when gray-white matter contrast in structural 
      images is low due to ongoing myelination in newborns and infants. This problem is 
      of particularly clinical relevance for imaging infants with inborn or acquired 
      disorders that impair normal brain development. We investigated whether the ASL 
      MRI perfusion contrast is a viable alternative for spatial normalization, using a 
      pseudo-continuous ASL acquired using a 1.5 T MRI unit (GE Healthcare). Four 
      approaches have been compared: (1) using the structural image contrast, or 
      perfusion contrast with (2) rigid, (3) affine, and (4) nonlinear transformations 
      - in 16 healthy controls [median age 0.83 years, inter-quartile range (IQR) +/- 
      0.56] and 36 trigonocephaly patients (median age 0.50 years, IQR +/- 0.30) - a 
      non-syndromic type of craniosynostosis. Performance was compared quantitatively 
      using the real-valued Tanimoto coefficient (TC), visually by three blinded 
      readers, and eventually by the impact on regional cerebral blood flow (CBF) 
      values. For both patients and controls, nonlinear registration using perfusion 
      contrast showed the highest TC, at 17.51 (CI 6.66-49.38) times more likely to 
      have a higher rating and 17.45-18.88 ml/100 g/min higher CBF compared with the 
      standard normalization. Using perfusion-based contrast improved spatial 
      normalization compared with the use of structural images, significantly affected 
      the regional CBF, and may open up new possibilities for future large pediatric 
      ASL brain studies.
CI  - Copyright (c) 2021 de Planque, Mutsaerts, Keil, Erler, Dremmen, Mathijssen and 
      Petr.
FAU - de Planque, Catherine A
AU  - de Planque CA
AD  - Department of Plastic and Reconstructive Surgery and Hand Surgery, University 
      Medical Center Rotterdam, Rotterdam, Netherlands.
FAU - Mutsaerts, Henk J M M
AU  - Mutsaerts HJMM
AD  - Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam 
      University Medical Center, Amsterdam, Netherlands.
FAU - Keil, Vera C
AU  - Keil VC
AD  - Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam 
      University Medical Center, Amsterdam, Netherlands.
FAU - Erler, Nicole S
AU  - Erler NS
AD  - Department of Biostatistics, University Medical Center Rotterdam, Rotterdam, 
      Netherlands.
AD  - Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands.
FAU - Dremmen, Marjolein H G
AU  - Dremmen MHG
AD  - Department of Radiology and Nuclear Medicine, University Medical Center 
      Rotterdam, Rotterdam, Netherlands.
FAU - Mathijssen, Irene M J
AU  - Mathijssen IMJ
AD  - Department of Plastic and Reconstructive Surgery and Hand Surgery, University 
      Medical Center Rotterdam, Rotterdam, Netherlands.
FAU - Petr, Jan
AU  - Petr J
AD  - Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam 
      University Medical Center, Amsterdam, Netherlands.
AD  - Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer 
      Research, Dresden, Germany.
LA  - eng
PT  - Journal Article
DEP - 20210719
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC8326566
OTO - NOTNLM
OT  - ASL
OT  - craniosynostosis
OT  - pediatric
OT  - registration
OT  - segmentation
OT  - spatial normalization
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/08/06 06:00
MHDA- 2021/08/06 06:01
PMCR- 2021/01/01
CRDT- 2021/08/05 06:23
PHST- 2021/04/20 00:00 [received]
PHST- 2021/06/04 00:00 [accepted]
PHST- 2021/08/05 06:23 [entrez]
PHST- 2021/08/06 06:00 [pubmed]
PHST- 2021/08/06 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2021.698007 [doi]
PST - epublish
SO  - Front Neurosci. 2021 Jul 19;15:698007. doi: 10.3389/fnins.2021.698007. 
      eCollection 2021.