PMID- 34352498 OWN - NLM STAT- MEDLINE DCOM- 20220214 LR - 20220214 IS - 1878-3252 (Electronic) IS - 0946-672X (Linking) VI - 68 DP - 2021 Dec TI - Interactive effects of serum ferritin and high sensitivity C-reactive protein on diabetes in hypertensive patients. PG - 126824 LID - S0946-672X(21)00114-0 [pii] LID - 10.1016/j.jtemb.2021.126824 [doi] AB - BACKGROUND: Hypertensive patients, often characterized by chronic inflammation, are susceptible to diabetes. Evidence suggests that the positive association between serum ferritin (SF) and diabetes was affected by high-sensitivity C-reactive protein (hs-CRP), an inflammation marker. We investigate whether there was an interaction between SF and hs-CRP on diabetes in hypertensive patients. METHODS: We analysed data of 1,735 hypertensive people in this cross-sectional study. Diabetes was diagnosed when fasting blood glucose >/= 7.0 mmol/L and/or a previous clinical diagnosis of diabetes. Logistic regression models were used to estimate the association of the SF and hs-CRP with diabetes. Multiplicative interaction was evaluated by incorporating a cross-product term for SF and hs-CRP to the logistic regression model. Additive interaction was assessed by calculating the relative excess risk of interaction (RERI) and attributed proportion due to interaction (AP). RESULTS: In the adjusted analysis, SF (highest vs lowest tertile: odds ratio [OR], 1.61; 95 % confidence interval [CI], 1.20-2.16) was positively associated with diabetes. There was no multiplicative interaction between SF and hs-CRP, but evidence of additive interaction in regard to diabetes (RERI: 0.86; 95 % CI: 0.06-1.67). Compared to the patients with low SF (lower two thirds) and low hs-CRP ( 2 mg/L) had increased OR for diabetes (adjusted OR: 2.33 [1.65-3.30]), with 37.0 % of the effects attributed to the additive interaction (AP: 0.37; 95 % CI: 0.09-0.65). CONCLUSIONS: Within a cross-sectional study consisting of hypertensive patients, co-exposure to high SF and high hs-CRP was synergistically associated with diabetes. Dietary intervention or pharmacological treatment to lowering SF concentration may help to reduce diabetes morbidity in hypertensive patient with chronic inflammation. CI - Copyright (c) 2021 Elsevier GmbH. All rights reserved. FAU - Zhou, Juan AU - Zhou J AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, and Ministry of Education (MOE) Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430030, PR China. FAU - Wang, Ning AU - Wang N AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, and Ministry of Education (MOE) Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430030, PR China. FAU - Wang, Dongxia AU - Wang D AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, and Ministry of Education (MOE) Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430030, PR China. FAU - Zhao, Rui AU - Zhao R AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, and Ministry of Education (MOE) Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430030, PR China. FAU - Zhao, Dan AU - Zhao D AD - Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong Province, 518051, PR China. FAU - Ouyang, Binfa AU - Ouyang B AD - Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong Province, 518051, PR China. FAU - Peng, Xiaolin AU - Peng X AD - Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong Province, 518051, PR China. FAU - Hao, Liping AU - Hao L AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, and Ministry of Education (MOE) Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430030, PR China. Electronic address: haolp@mails.tjmu.edu.cn. LA - eng PT - Journal Article DEP - 20210728 PL - Germany TA - J Trace Elem Med Biol JT - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) JID - 9508274 RN - 9007-41-4 (C-Reactive Protein) RN - 9007-73-2 (Ferritins) SB - IM MH - C-Reactive Protein/*metabolism MH - Cross-Sectional Studies MH - *Diabetes Mellitus MH - Ferritins/*blood MH - Humans MH - *Hypertension MH - Inflammation MH - Risk Factors OTO - NOTNLM OT - Additive interaction OT - Diabetes OT - Ferritin OT - Hypertension OT - hs-CRP EDAT- 2021/08/06 06:00 MHDA- 2022/02/15 06:00 CRDT- 2021/08/05 20:21 PHST- 2021/02/22 00:00 [received] PHST- 2021/06/07 00:00 [revised] PHST- 2021/07/26 00:00 [accepted] PHST- 2021/08/06 06:00 [pubmed] PHST- 2022/02/15 06:00 [medline] PHST- 2021/08/05 20:21 [entrez] AID - S0946-672X(21)00114-0 [pii] AID - 10.1016/j.jtemb.2021.126824 [doi] PST - ppublish SO - J Trace Elem Med Biol. 2021 Dec;68:126824. doi: 10.1016/j.jtemb.2021.126824. Epub 2021 Jul 28.