PMID- 34353031 OWN - NLM STAT- MEDLINE DCOM- 20210809 LR - 20210809 IS - 2224-5839 (Electronic) IS - 2224-5820 (Linking) VI - 10 IP - 7 DP - 2021 Jul TI - New pulmonary rehabilitation exercise for pulmonary fibrosis to improve the pulmonary function and quality of life of patients with idiopathic pulmonary fibrosis: a randomized control trial. PG - 7289-7297 LID - 10.21037/apm-21-71 [doi] AB - BACKGROUND: The aim of our study is to investigate the impact of the simple breathing exercises (LHP's respiratory rehabilitation for pulmonary fibrosis, LHP's RRPF) on patients with idiopathic pulmonary fibrosis (IPF). METHODS: (I) The safety and effectiveness of LHP's RRPF were first verified in 20 healthy individuals. (II) A total of 101 patients with IPF administrated in Shanghai Pulmonary Hospital between January 2015 and May 2017 were screened, and 82 cases were randomly assigned to receive a 12-month LHP's RRPF program (exercise group) or usual medical care (control group). Lung function, chest X-ray, 6-minute walk distance (6MWD), quality of life (St. George's Respiratory Questionnaire, SGRQ), and EKG were measured at the 6th and 12th month during the trial. RESULTS: At the 6th month visit, the exercise group showed improved SGRQ score and lung function parameters (FVC, FEV1, and DLCO). At the 12th months visit, the exercise group had significantly improved SGRQ score, 6MWD, and lung function (FVC, FEV1, and DLCO) compared to the control group (P<0.05). No obvious adverse events occurred in the exercise group. The incidence of acute exacerbation and one-year mortality were 7.69% and 2.56%, respectively in the exercise group, which were lower than those (20.9% and 9.3%, respectively) in the control group. CONCLUSIONS: LHP's RRPF can delay the pulmonary function decline of patients with IPF and improve their quality of life. This breathing exercise may be an adjunct to pulmonary rehabilitation for IPF. FAU - Shen, Li AU - Shen L AD - Medical College of Soochow University, Suzhou, China; Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China. FAU - Zhang, Yuan AU - Zhang Y AD - Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China. FAU - Su, Yiliang AU - Su Y AD - Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China. FAU - Weng, Dong AU - Weng D AD - Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China. FAU - Zhang, Fen AU - Zhang F AD - Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China. FAU - Wu, Qin AU - Wu Q AD - Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China. FAU - Chen, Tao AU - Chen T AD - Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China. FAU - Li, Qiuhong AU - Li Q AD - Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China. FAU - Zhou, Ying AU - Zhou Y AD - Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China. FAU - Hu, Yang AU - Hu Y AD - Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China. FAU - Jiang, Xing AU - Jiang X AD - Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China. FAU - Jin, Xiaofeng AU - Jin X AD - Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China. FAU - Zhang, Aihong AU - Zhang A AD - Department of Medical Statistics, Tongji University, School of Medicine, Shanghai, China. FAU - Li, Huiping AU - Li H AD - Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China. LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - China TA - Ann Palliat Med JT - Annals of palliative medicine JID - 101585484 SB - IM MH - China MH - Exercise Therapy MH - Humans MH - *Idiopathic Pulmonary Fibrosis/therapy MH - Lung MH - *Quality of Life OTO - NOTNLM OT - LHP's respiratory rehabilitation for pulmonary fibrosis (LHP's RRPF) OT - forced vital capacity OT - quality of life EDAT- 2021/08/07 06:00 MHDA- 2021/08/10 06:00 CRDT- 2021/08/06 05:27 PHST- 2021/01/11 00:00 [received] PHST- 2021/05/29 00:00 [accepted] PHST- 2021/08/06 05:27 [entrez] PHST- 2021/08/07 06:00 [pubmed] PHST- 2021/08/10 06:00 [medline] AID - 10.21037/apm-21-71 [doi] PST - ppublish SO - Ann Palliat Med. 2021 Jul;10(7):7289-7297. doi: 10.21037/apm-21-71.