PMID- 34353101
OWN - NLM
STAT- MEDLINE
DCOM- 20210809
LR  - 20210809
IS  - 2224-5839 (Electronic)
IS  - 2224-5820 (Linking)
VI  - 10
IP  - 7
DP  - 2021 Jul
TI  - Association between plasma homocysteine levels and pancreatic islet beta-cell 
      function in the patients with type 2 diabetes mellitus: a cross-sectional study 
      from China.
PG  - 8169-8179
LID - 10.21037/apm-21-1671 [doi]
AB  - BACKGROUND: This study sought to investigate the association between plasma 
      homocysteine (HCY) levels and pancreatic islet beta-cell function in type 2 
      diabetes mellitus (T2DM) patients. METHODS: 430 hospitalized T2DM patients were 
      enrolled in this cross-sectional study from December 2013 to December 2016. All 
      participants were requested to complete a detailed questionnaire and undergo 
      anthropometric measurements. Blood samples were collected from all participants. 
      A 75-g oral glucose tolerance test (OGTT) was performed to diagnose T2DM in each 
      individual, and an insulin releasing test (IRT) was used to calculate selected 
      parameters for glucose, insulin, and C-peptide. Linear correlation and 
      multivariate regression analyses were performed to assess the association between 
      serum HCY concentration and these parameters. RESULTS: Patients were divided into 
      the following subgroups based on quartiles of serum HCY levels: Group Q1: <17.03 
      micromol/L; Group Q2: 17.03-19.50 micromol/L; Group Q3: 19.5-24.7 micromol/L; and Group Q4: 
      >24.7 micromol/L. The levels of fasting blood glucose (FBG), 2 h postprandial blood 
      glucose (2hPBG), glycated hemoglobin A1c (HbA1c), fasting C-peptide and fasting 
      insulin increased significantly as HCY levels increased (P<0.05). The area under 
      the curves (AUCs) of serum glucose and insulin in IRT increased significantly and 
      that of serum C-peptide decreased as HCY levels increased (P<0.05). The levels of 
      Homeostasis Model Assessment-beta (HOMA-beta), Modified Beta-cell function Index 
      (MBCI), Disposal Index (DI), C-peptide immunoreactivity (CPR), Insulinogenic 
      Index 30 (IGI 30), and Secretory Units of Islets in Transplantation (SUIT) 
      decreased as HCY levels increased. An inverse linear correlation was found 
      between HOMA-beta, MBCI, DI, CPR, IGI 30, SUIT 0 h, and HCY plasma concentration 
      (R2, 0.539, 0.569, 0.500, 0.676, 0.579, and 0.588, respectively; P<0.001), and 
      this association was independent of many confounders, such as age, gender, body 
      mass index, glucose and insulin levels, and HbA1c. CONCLUSIONS: Serum HCY levels 
      were inversely related to the parameters for pancreatic islet beta-cell function. 
      Thus, the insulin releasing function of beta cells in the pancreas can be well 
      elucidated by plasma HCY concentration.
FAU - Yuan, Xinlu
AU  - Yuan X
AD  - Department of Endocrinology and Metabolic Diseases, Shanghai Pudong Hospital, 
      Fudan University Pudong Medical Center, Shanghai, China; Department of 
      Endocrinology and Metabolic Diseases, Affiliated Hospital of Nantong University, 
      Nantong, China.
FAU - Ding, Sheng
AU  - Ding S
AD  - Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, China.
FAU - Zhou, Ligang
AU  - Zhou L
AD  - Department of Endocrinology and Metabolic Diseases, Shanghai Pudong Hospital, 
      Fudan University Pudong Medical Center, Shanghai, China.
FAU - Wen, Song
AU  - Wen S
AD  - Department of Endocrinology and Metabolic Diseases, Shanghai Pudong Hospital, 
      Fudan University Pudong Medical Center, Shanghai, China.
FAU - Du, Anqing
AU  - Du A
AD  - Department of Stomatology, Shanghai Pudong Hospital, Fudan University Pudong 
      Medical Center, Shanghai, China.
FAU - Diao, Jianjun
AU  - Diao J
AD  - Department of Emergency, Shanghai Pudong Hospital, Fudan University Pudong 
      Medical Center, Shanghai, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Palliat Med
JT  - Annals of palliative medicine
JID - 101585484
RN  - 0 (Blood Glucose)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Blood Glucose
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2
MH  - Homocysteine
MH  - Humans
MH  - *Insulin Resistance
MH  - *Islets of Langerhans
OTO - NOTNLM
OT  - Homeostasis Model Assessment-beta (HOMA-beta)
OT  - Type 2 diabetes mellitus (T2DM)
OT  - homocysteine
OT  - pancreatic islet beta-cells function
EDAT- 2021/08/07 06:00
MHDA- 2021/08/10 06:00
CRDT- 2021/08/06 05:27
PHST- 2021/06/07 00:00 [received]
PHST- 2021/07/13 00:00 [accepted]
PHST- 2021/08/06 05:27 [entrez]
PHST- 2021/08/07 06:00 [pubmed]
PHST- 2021/08/10 06:00 [medline]
AID - 10.21037/apm-21-1671 [doi]
PST - ppublish
SO  - Ann Palliat Med. 2021 Jul;10(7):8169-8179. doi: 10.21037/apm-21-1671.