PMID- 34354158
OWN - NLM
STAT- MEDLINE
DCOM- 20211108
LR  - 20211108
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Aug 5
TI  - Interaction between CETP polymorphism and dietary insulin index and load in 
      relation to cardiovascular risk factors in diabetic adults.
PG  - 15906
LID - 10.1038/s41598-021-95359-y [doi]
LID - 15906
AB  - Gene-diet interactions may play an important role in the inter individual 
      diversity observed in on cardiovascular disease (CVD) risk factors. Therefore, in 
      the current study, we examined the interaction of CETP TaqB1 polymorphism with 
      dietary insulin index and load (DII and DIL), in altering on CVD risk factors 
      among type 2 diabetes mellitus (T2DM). In this cross-sectional study, blood 
      samples were collected from 220 type 2 diabetic patients (134 females and 86 
      male) with a mean age of 52.24 years in Tehran, Iran. DIL and DII were obtained 
      via validated food-frequency questionnaire (FFQ). Taq1B polymorphism was 
      genotyped by the polymerase chain reaction-restriction fragment length 
      polymorphism (PCR-RFLP) method. Biochemical markers including total cholesterol 
      (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride 
      (TG), superoxide dismutase (SOD), C-reactive protein (CRP), total antioxidant 
      capacity (TAC), pentraxin-3 (PTX3), isoprostaneF2alpha (PGF2alpha). interleukin 18 
      (IL18), leptin and ghrelin were measured by standard protocol. Patients with B1B1 
      genotype had lower lipid profiles include LDL/HDL (P < 0.001) and TG (P = 0.04) 
      when they consumed diets higher on the DIL and DII index. Moreover, carriers of 
      B2B2 genotype who were in the last tertile of DIL had higher antioxidant and 
      inflammatory markers include SOD (P = 0.01), PGF2alpha (P = 0.04) and CRP (P = 0.02). 
      Further, a significant interaction between CETP TaqB1 and DII was shown in terms 
      of WC (P = 0.01), where the highest WC were observed in B2B2 genotype carriers 
      following a DII score. However, the highest inflammatory and antioxidant markers 
      include CRP (P = 0.04), TAC (P = 0.01), SOD (P = 0.02), and PGF2alpha (P = 0.02) were 
      observed in B2B2 genotype carriers when they consumed diets higher on the DII 
      index. Based on the current study, it could be proposed that CETP polymorphism 
      may be associated with CVD risk factors in T2DM patients with high following 
      insulin indices, including DII and DIL. It seems that CETP Taq1B polymorphism can 
      invert the result produced by insulin. This conclusion illustrates that the CETP 
      Taq1B B1 allele could counteract the CVD risk induced by high DII and DIL.
CI  - (c) 2021. The Author(s).
FAU - Abaj, Faezeh
AU  - Abaj F
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Rafiee, Masoumeh
AU  - Rafiee M
AD  - Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan 
      University of Medical Sciences (IUMS), Isfahan, Iran. masomeh.rafiei@gmail.com.
FAU - Koohdani, Fariba
AU  - Koohdani F
AD  - Department of Cellular, Molecular Nutrition, School of Nutritional Sciences and 
      Dietetics, Tehran University of Medical Sciences (TUMS), PO Box: 141556117, 
      Tehran, Iran. fkoohdan@tums.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210805
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (CETP protein, human)
RN  - 0 (Cholesterol Ester Transfer Proteins)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Cardiovascular Diseases/etiology/genetics
MH  - Cholesterol Ester Transfer Proteins/*genetics/metabolism
MH  - Cross-Sectional Studies
MH  - Diabetes Complications/genetics/metabolism
MH  - Diabetes Mellitus, Type 2/*genetics/metabolism
MH  - Diet/methods
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genotype
MH  - Heart Disease Risk Factors
MH  - Humans
MH  - Insulin/*metabolism
MH  - Iran/epidemiology
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/genetics
PMC - PMC8342557
COIS- The authors declare no competing interests.
EDAT- 2021/08/07 06:00
MHDA- 2021/11/09 06:00
PMCR- 2021/08/05
CRDT- 2021/08/06 06:24
PHST- 2021/02/28 00:00 [received]
PHST- 2021/06/24 00:00 [accepted]
PHST- 2021/08/06 06:24 [entrez]
PHST- 2021/08/07 06:00 [pubmed]
PHST- 2021/11/09 06:00 [medline]
PHST- 2021/08/05 00:00 [pmc-release]
AID - 10.1038/s41598-021-95359-y [pii]
AID - 95359 [pii]
AID - 10.1038/s41598-021-95359-y [doi]
PST - epublish
SO  - Sci Rep. 2021 Aug 5;11(1):15906. doi: 10.1038/s41598-021-95359-y.