PMID- 34354403
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231107
IS  - 1319-562X (Print)
IS  - 2213-7106 (Electronic)
IS  - 2213-7106 (Linking)
VI  - 28
IP  - 8
DP  - 2021 Aug
TI  - Coconut products alleviate hyperglycaemic, hyperlipidimic and nephropathy indices 
      in streptozotocin-induced diabetic wistar rats.
PG  - 4224-4231
LID - 10.1016/j.sjbs.2021.06.060 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a chronic and one of the most common metabolic 
      diseases affecting large proportion of world population. Diabetes-induced changes 
      in lipid and renal parameters are major risk factors contributing to diabetic 
      complications such as diabetic nephropathy and cardiovascular diseases. Due to 
      adverse effects associated with pharmacological intervention in the T2DM 
      treatment, there is an increased interest in the research focussing on 
      identifying novel plant based therapeutic agents. Here we report the effects of 
      various coconut products on diabetic, lipid and renal parameters in 
      streptozotocin (STZ)-induced diabetic rat model. Diabetic rats demonstrated a 
      significant increase in serum glucose, and glycated haemoglobin levels (HbA1c). 
      Lipid parameters including triglycerides, total cholesterol, low density 
      lipoprotein cholesterol (LDL-cholesterol) and very low density lipoprotein 
      cholesterol (VLDL-cholesterol) were found to be significantly increased, while 
      high density lipoprotein cholesterol (HDL-cholesterol) was significantly declined 
      in diabetic rats. Diabetic rats also displayed increased serum and kidney 
      creatinine, urea, and total protein levels and increased urine glucose, urea, 
      albumin and creatinine levels. Contrastingly, treatment with virgin and filtered 
      coconut oils, coconut water and coconut milk resulted in a significant reversal 
      in the levels of above studied parameters in diabetic rats. Further, these 
      coconut products markedly prevented diabetes induced histopathological changes in 
      kidney tissue. Collectively, the data demonstrate the antidiabetic, hypolipidemic 
      and renal protective properties of various coconut products and underscore the 
      importance of regular consumption of plant based medicinal products in the 
      treatment of T2DM and its complications.
CI  - (c) 2021 The Authors.
FAU - Alatawi, Karemah A
AU  - Alatawi KA
AD  - Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 
      21533, Saudi Arabia.
FAU - Alshubaily, Fawzia A
AU  - Alshubaily FA
AD  - Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 
      21533, Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20210625
PL  - Saudi Arabia
TA  - Saudi J Biol Sci
JT  - Saudi journal of biological sciences
JID - 101543796
PMC - PMC8324991
OTO - NOTNLM
OT  - Coconut milk
OT  - Coconut products
OT  - Diabetes
OT  - Filtered coconut oil
OT  - Inflammation
OT  - Kidney
OT  - Virgin coconut oil
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2021/08/07 06:00
MHDA- 2021/08/07 06:01
PMCR- 2021/06/25
CRDT- 2021/08/06 06:47
PHST- 2021/05/18 00:00 [received]
PHST- 2021/06/21 00:00 [revised]
PHST- 2021/06/21 00:00 [accepted]
PHST- 2021/08/06 06:47 [entrez]
PHST- 2021/08/07 06:00 [pubmed]
PHST- 2021/08/07 06:01 [medline]
PHST- 2021/06/25 00:00 [pmc-release]
AID - S1319-562X(21)00532-5 [pii]
AID - 10.1016/j.sjbs.2021.06.060 [doi]
PST - ppublish
SO  - Saudi J Biol Sci. 2021 Aug;28(8):4224-4231. doi: 10.1016/j.sjbs.2021.06.060. Epub 
      2021 Jun 25.