PMID- 34354968
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210807
IS  - 2296-2360 (Print)
IS  - 2296-2360 (Electronic)
IS  - 2296-2360 (Linking)
VI  - 9
DP  - 2021
TI  - Case Report: Hyper IgE, but Not the Usual Suspects-Kimura Disease in an 
      Adolescent Female.
PG  - 674317
LID - 10.3389/fped.2021.674317 [doi]
LID - 674317
AB  - Elevated immunoglobulin E (IgE) levels can be associated with infectious, 
      allergic and inflammatory disorders, and rarely as a manifestation of an inborn 
      error of immunity. Here we report the case of an adolescent female who presented 
      with a gradually enlarging neck mass, lymphadenopathy, eosinophilia and highly 
      elevated IgE levels. Laboratory and histopathologic evaluation revealed an 
      unlikely diagnosis of Kimura Disease. We discuss the differential diagnosis of a 
      neck mass with prominent eosinophils on histology, and review support for 
      T-helper type 2 (Th2) cell activation and hyper-IgE in Kimura Disease.
CI  - Copyright (c) 2021 Ramachandran, Healy, Lambert, Guerra, Curry and Vogel.
FAU - Ramachandran, Prasanna Venkatesh
AU  - Ramachandran PV
AD  - Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
AD  - Pediatrician-Scientist Program, Baylor College of Medicine, Houston, TX, United 
      States.
AD  - Texas Children's Hospital, Houston, TX, United States.
FAU - Healy, C Mary
AU  - Healy CM
AD  - Texas Children's Hospital, Houston, TX, United States.
AD  - Division of Infectious Disease, Department of Pediatrics, Baylor College of 
      Medicine, Houston, TX, United States.
FAU - Lambert, Elton M
AU  - Lambert EM
AD  - Texas Children's Hospital, Houston, TX, United States.
AD  - Division of Otolaryngology, Department of Pediatrics, Baylor College of Medicine, 
      Houston, TX, United States.
FAU - Guerra, Deyanara
AU  - Guerra D
AD  - Texas Children's Hospital, Houston, TX, United States.
FAU - Curry, Choladda V
AU  - Curry CV
AD  - Texas Children's Hospital, Houston, TX, United States.
AD  - Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, 
      United States.
FAU - Vogel, Tiphanie P
AU  - Vogel TP
AD  - Texas Children's Hospital, Houston, TX, United States.
AD  - Division of Rheumatology, Department of Pediatrics, Baylor College of Medicine, 
      Houston, TX, United States.
LA  - eng
PT  - Case Reports
DEP - 20210720
PL  - Switzerland
TA  - Front Pediatr
JT  - Frontiers in pediatrics
JID - 101615492
PMC - PMC8329340
OTO - NOTNLM
OT  - IgE
OT  - IgG4-related disease
OT  - Kimura Disease
OT  - T helper 2
OT  - angiolymphoid hyperplasia with eosinophilia
OT  - lymphocytic hypereosinophilic syndrome
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/08/07 06:00
MHDA- 2021/08/07 06:01
PMCR- 2021/07/20
CRDT- 2021/08/06 06:54
PHST- 2021/03/01 00:00 [received]
PHST- 2021/06/21 00:00 [accepted]
PHST- 2021/08/06 06:54 [entrez]
PHST- 2021/08/07 06:00 [pubmed]
PHST- 2021/08/07 06:01 [medline]
PHST- 2021/07/20 00:00 [pmc-release]
AID - 10.3389/fped.2021.674317 [doi]
PST - epublish
SO  - Front Pediatr. 2021 Jul 20;9:674317. doi: 10.3389/fped.2021.674317. eCollection 
      2021.