PMID- 34355700
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210914
IS  - 2049-3614 (Print)
IS  - 2049-3614 (Electronic)
IS  - 2049-3614 (Linking)
VI  - 10
IP  - 9
DP  - 2021 Sep 1
TI  - Homocysteine is an indicator of arterial stiffness in Chinese women with 
      polycystic ovary syndrome.
PG  - 1073-1079
LID - EC-21-0224 [pii]
LID - 10.1530/EC-21-0224 [doi]
AB  - Polycystic ovary syndrome (PCOS) is associated with an increased risk of 
      cardiovascular disease in women. Hyperhomocysteinemia (H-Hcy) is closely related 
      to arterial stiffness (AS) in patients with cardiovascular disease. This study 
      aimed to investigate the relationship between serum homocysteine(Hcy) level and 
      brachial-ankle pulse wave velocity (baPWV) in Chinese women with PCOS. A total of 
      124 PCOS women were enrolled and divided into two groups according to their baPWV 
      values: normal, baPWV < 1400 cm/s and high AS, baPWV >/= 1400 cm/s. Univariate 
      analysis was performed to investigate the relative factors for baPWV, and 
      multiple regression analysis was used to evaluate the association of Hcy with 
      baPWV. The group with high AS (n = 35) had higher Hcy levels than the other group 
      (n = 89; P < 0.05). Moreover, univariate analysis revealed that serum Hcy was 
      positively correlated with baPWV (r = 0.133, P < 0.01). In multiple regression 
      analysis, the age-adjusted serum Hcy level was positively correlated with baPWV 
      (beta = 0.201, P < 0.01). It remained positively associated with baPWV (beta = 0.145, P 
      < 0.01) after further adjustments for age, BMI, PCOS duration, systolic blood 
      pressure, and homeostasis model assessment-insulin resistance as well as several 
      other factors correlated with baPWV. Our results demonstrated that H-Hcy was 
      significantly and independently related to elevated baPWV, suggesting that Hcy 
      might play a role in the pathologic process of AS in women with PCOS. Further 
      researches with more subjects are needed to explore whether Hcy would be a 
      promising biomarker for the stratification management of PCOS women.
FAU - Wu, Xia
AU  - Wu X
AD  - Department of Endocrinology, Jing'an District Centre Hospital of Shanghai 
      (Huashan Hospital Fudan University Jing'an Branch), Shanghai, China.
FAU - Li, Zhiling
AU  - Li Z
AD  - Department of Pharmacy, Shanghai Children's Hospital, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Sun, Wenjiang
AU  - Sun W
AD  - Department of Rehabilitation, Shanghai General Hospital, Jiaotong University, 
      Shanghai, China.
FAU - Zheng, Huan
AU  - Zheng H
AD  - Department of Cardiology, Worldpath Clinic International, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20210901
PL  - England
TA  - Endocr Connect
JT  - Endocrine connections
JID - 101598413
PMC - PMC8428028
OTO - NOTNLM
OT  - arterial stiffness
OT  - homocysteine
OT  - polycystic ovary syndrome
EDAT- 2021/08/07 06:00
MHDA- 2021/08/07 06:01
PMCR- 2021/08/06
CRDT- 2021/08/06 08:44
PHST- 2021/07/20 00:00 [received]
PHST- 2021/08/06 00:00 [accepted]
PHST- 2021/08/07 06:00 [pubmed]
PHST- 2021/08/07 06:01 [medline]
PHST- 2021/08/06 08:44 [entrez]
PHST- 2021/08/06 00:00 [pmc-release]
AID - EC-21-0224 [pii]
AID - 10.1530/EC-21-0224 [doi]
PST - epublish
SO  - Endocr Connect. 2021 Sep 1;10(9):1073-1079. doi: 10.1530/EC-21-0224.