PMID- 34358406
OWN - NLM
STAT- MEDLINE
DCOM- 20220105
LR  - 20220105
IS  - 1522-726X (Electronic)
IS  - 1522-1946 (Linking)
VI  - 98
IP  - 7
DP  - 2021 Dec 1
TI  - Implications of concomitant obstructive or restrictive pulmonary diseases on 
      functional and clinical results after MitraClip.
PG  - E1000-E1006
LID - 10.1002/ccd.29893 [doi]
AB  - OBJECTIVES: We investigated the impact of underlying pulmonary limitations (PL) 
      on symptoms and clinical outcomes after transcatheter mitral valve repair (TMVr). 
      BACKGROUND: Patients with pulmonary disease and patients with symptomatic mitral 
      regurgitation (MR) suffer common symptoms like dyspnea and reduced exercise 
      capacity. METHODS: Datasets from the TMVr Ulm registry were retrospectively 
      analyzed by a blinded specialist in pneumology. Patients were dichotomized 
      according to an unambiguous manifestation of concomitant pulmonary disease in a 
      PL-group and a non-PL-group and were analyzed regarding baseline characteristics 
      and clinical follow-up. RESULTS: Overall, 483 patients were included in the study 
      of which 32.3% (n = 156) showed an underlying pulmonary disease. Patients in the 
      PL-group were similar to patients in the non-PL-group, including Euro SCORE II 
      (8.2 vs. 8.4, p = 0.39), New York Heart Association (NYHA) classification 
      (3.2 +/- 0.7 in both groups, p = 0.65) and the incidence of moderate-to-severe or 
      severe MR after TMVr (5.8 vs. 8.3%, p = 0.32). Equal and significant symptom 
      relief after TMVr was experienced in both cohorts according to NYHA functional 
      class (2.24 +/- 0.84 vs. 2.24 +/- 0.86, p = 0.93) and rate of hospitalization during 
      2 years of follow-up decreased comparably from 61.1 to 19.3%. However, all-cause 
      mortality for 2 year follow-up was significantly higher in the PL-group compared 
      to the non-PL-group (31.4 vs. 21.4%, p = 0.018). CONCLUSION: In patients with MR 
      and concomitant pulmonary disorders, a significant increase of exercise capacity 
      and a significant decrease of rehospitalization rate were observed after TMVr. 
      Nevertheless, all-cause mortality remains significantly increased within a 
      follow-up period of 2 years compared to patients without pulmonary disorders.
CI  - (c) 2021 The Authors. Catheterization and Cardiovascular Interventions published by 
      Wiley Periodicals LLC.
FAU - Schneider, Leonhard Moritz
AU  - Schneider LM
AD  - Department of Cardiology, Angiology, and Pneumology, University of Ulm, Ulm, 
      Germany.
FAU - Nicoleta, Nita
AU  - Nicoleta N
AD  - Department of Cardiology, Angiology, and Pneumology, University of Ulm, Ulm, 
      Germany.
FAU - Schepperle, Niklas
AU  - Schepperle N
AD  - Department of Cardiology, Angiology, and Pneumology, University of Ulm, Ulm, 
      Germany.
FAU - Paukovitsch, Michael
AU  - Paukovitsch M
AUID- ORCID: 0000-0002-8056-3908
AD  - Department of Cardiology, Angiology, and Pneumology, University of Ulm, Ulm, 
      Germany.
FAU - Haide, Uli
AU  - Haide U
AD  - Department of Cardiology, Angiology, and Pneumology, University of Ulm, Ulm, 
      Germany.
FAU - Feuerabendt, Sieglinde
AU  - Feuerabendt S
AD  - Department of Cardiology, Angiology, and Pneumology, University of Ulm, Ulm, 
      Germany.
FAU - Kessler, Mirjam
AU  - Kessler M
AUID- ORCID: 0000-0001-6423-0508
AD  - Department of Cardiology, Angiology, and Pneumology, University of Ulm, Ulm, 
      Germany.
FAU - Rottbauer, Wolfgang
AU  - Rottbauer W
AD  - Department of Cardiology, Angiology, and Pneumology, University of Ulm, Ulm, 
      Germany.
FAU - Markovic, Sinisa
AU  - Markovic S
AUID- ORCID: 0000-0001-9708-0702
AD  - Department of Cardiology, Angiology, and Pneumology, University of Ulm, Ulm, 
      Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210806
PL  - United States
TA  - Catheter Cardiovasc Interv
JT  - Catheterization and cardiovascular interventions : official journal of the 
      Society for Cardiac Angiography & Interventions
JID - 100884139
SB  - IM
MH  - Cardiac Catheterization/adverse effects
MH  - *Heart Valve Prosthesis Implantation/adverse effects
MH  - Humans
MH  - *Lung Diseases/diagnosis
MH  - Mitral Valve/diagnostic imaging/surgery
MH  - *Mitral Valve Insufficiency/diagnostic imaging/surgery
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - COPD
OT  - MitraClip
OT  - NYHA class
EDAT- 2021/08/07 06:00
MHDA- 2022/01/06 06:00
CRDT- 2021/08/06 17:29
PHST- 2021/06/28 00:00 [revised]
PHST- 2020/11/29 00:00 [received]
PHST- 2021/07/16 00:00 [accepted]
PHST- 2021/08/07 06:00 [pubmed]
PHST- 2022/01/06 06:00 [medline]
PHST- 2021/08/06 17:29 [entrez]
AID - 10.1002/ccd.29893 [doi]
PST - ppublish
SO  - Catheter Cardiovasc Interv. 2021 Dec 1;98(7):E1000-E1006. doi: 10.1002/ccd.29893. 
      Epub 2021 Aug 6.