PMID- 34358558
OWN - NLM
STAT- MEDLINE
DCOM- 20220224
LR  - 20220224
IS  - 1878-5867 (Electronic)
IS  - 0039-128X (Linking)
VI  - 174
DP  - 2021 Oct
TI  - Fat mass and obesity-associated gene expression and disease severity in type 2 
      diabetes mellitus.
PG  - 108897
LID - S0039-128X(21)00109-4 [pii]
LID - 10.1016/j.steroids.2021.108897 [doi]
AB  - Obesity and visceral adiposity are major risk factors for type 2 diabetes 
      mellitus (T2DM). The fat mass and obesity-associated (FTO) gene is associated 
      with increased risk of obesity and T2DM. The aim of this work was to study the 
      association between FTO gene expression and serum FTO protein level with disease 
      severity in T2DM patients. PATIENTS AND METHODS: One hundred T2DM patients were 
      divided into two equal groups according to diabetes control and complications and 
      fifty healthy controls were included in this study. FTO messenger ribonucleic 
      acid (mRNA) expression level was analyzed by Real time polymerase chain reaction 
      (PCR) technique and serum level of FTO protein was measured by ELISA. RESULTS: 
      FTO gene expression and FTO protein levels were increased in the two T2DM groups 
      compared to the control group with significant further increases in patients with 
      severe disease. FTO gene expression and FTO protein levels were positively 
      correlated with obesity, insulin resistance and blood glucose indices as well as 
      the presence of diabetic complications. Regression analyses showed that FTO gene 
      expression and FTO protein levels were risk factors for T2DM severity. 
      CONCLUSIONS: Increased FTO gene expression and its serum protein levels are 
      associated with increased T2DM severity.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Masoud Abd El Gayed, Eman
AU  - Masoud Abd El Gayed E
AD  - Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, 
      Menoufia University, Egypt.
FAU - Kamal El Din Zewain, Shimaa
AU  - Kamal El Din Zewain S
AD  - Internal Medicine Department, Faculty of Medicine, Menoufia University, Egypt.
FAU - Ragheb, Ahmed
AU  - Ragheb A
AD  - Internal Medicine Department, Faculty of Medicine, Menoufia University, Egypt.
FAU - ElNaidany, Sherin Sobhy
AU  - ElNaidany SS
AD  - Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, 
      Menoufia University, Egypt. Electronic address: sherinsobhy@ymail.com.
LA  - eng
PT  - Journal Article
DEP - 20210803
PL  - United States
TA  - Steroids
JT  - Steroids
JID - 0404536
SB  - IM
MH  - *Diabetes Mellitus, Type 2
OTO - NOTNLM
OT  - Fat-mass and obesity-associated gene
OT  - Insulin resistance
OT  - Obesity
OT  - Type2diabetes mellitus
EDAT- 2021/08/07 06:00
MHDA- 2022/02/25 06:00
CRDT- 2021/08/06 20:11
PHST- 2020/11/30 00:00 [received]
PHST- 2021/05/08 00:00 [revised]
PHST- 2021/07/20 00:00 [accepted]
PHST- 2021/08/07 06:00 [pubmed]
PHST- 2022/02/25 06:00 [medline]
PHST- 2021/08/06 20:11 [entrez]
AID - S0039-128X(21)00109-4 [pii]
AID - 10.1016/j.steroids.2021.108897 [doi]
PST - ppublish
SO  - Steroids. 2021 Oct;174:108897. doi: 10.1016/j.steroids.2021.108897. Epub 2021 Aug 
      3.