PMID- 34358649
OWN - NLM
STAT- MEDLINE
DCOM- 20211115
LR  - 20211115
IS  - 1879-0461 (Electronic)
IS  - 1040-8428 (Linking)
VI  - 167
DP  - 2021 Nov
TI  - A Systematic Review on Intensity Modulated Radiation Therapy for Mediastinal 
      Hodgkin's Lymphoma.
PG  - 103437
LID - S1040-8428(21)00225-0 [pii]
LID - 10.1016/j.critrevonc.2021.103437 [doi]
AB  - BACKGROUND: Secondary malignant neoplasms (SMNs) and cardiovascular diseases 
      induced by chemotherapy and radiotherapy represent the main cause of excess 
      mortality for early-stage Hodgkin lymphoma patients, especially when the 
      mediastinum is involved. Conformal radiotherapy techniques such as 
      Intensity-Modulated Radiation Therapy (IMRT) could allow a reduction of the dose 
      to the organs-at-risk (OARs) and therefore limit long-term toxicity. METHODS: We 
      performed a systematic review of the current literature regarding comparisons 
      between IMRT and conventional photon beam radiotherapy, or between different IMRT 
      techniques, for the treatment of mediastinal lymphoma. RESULTS AND CONCLUSIONS: 
      IMRT allows a substantial reduction of the volumes of OARs exposed to high doses, 
      reducing the risk of long-term toxicity. This benefit is conterbalanced by the 
      increase of volumes receiving low doses, that could potentially increase the risk 
      of SMNs. Treatment planning should be personalized on patient and disease 
      characteristics. Dedicated techniques such as "butterfly" VMAT often provide the 
      best trade-off.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Buglione, Michela
AU  - Buglione M
AD  - Universita degli Studi di Brescia, Department of Radiation Oncology, Brescia 
      University, P.le Spedali Civili 1, 25123 Brescia, Italy. Electronic address: 
      michela.buglione@unibs.it.
FAU - Guerini, Andrea Emanuele
AU  - Guerini AE
AD  - Universita degli Studi di Brescia, Department of Radiation Oncology, Brescia 
      University, P.le Spedali Civili 1, 25123 Brescia, Italy. Electronic address: 
      a.e.guerini@gmail.com.
FAU - Filippi, Andrea Riccardo
AU  - Filippi AR
AD  - Radiation Oncology, Fondazione IRCCS Policlinico San Matteo and University of 
      Pavia, Pavia, Italy. Electronic address: a.filippi@smatteo.pv.it.
FAU - Spiazzi, Luigi
AU  - Spiazzi L
AD  - Department of Radiation Oncology, ASST Spedali Civili di Brescia, P.le Spedali 
      Civili 1, 25123 Brescia, Italy. Electronic address: 
      luigi.spiazzi@asst-spedalicivili.it.
FAU - Pasinetti, Nadia
AU  - Pasinetti N
AD  - Universita degli Studi di Brescia, Department of Radiation Oncology, Brescia 
      University, P.le Spedali Civili 1, 25123 Brescia, Italy; Radiation Oncology 
      Service, ASST Valcamonica Esine, Italy. Electronic address: 
      nadia.pasinetti@aol.com.
FAU - Magli, Alessandro
AU  - Magli A
AD  - Department of Radiation Oncology, Udine General Hospital, Udine, Italy. 
      Electronic address: maglialessandro@hotmail.com.
FAU - Toraci, Cristian
AU  - Toraci C
AD  - Department of Radiation Oncology, ASST Spedali Civili di Brescia, P.le Spedali 
      Civili 1, 25123 Brescia, Italy. Electronic address: c.toraci@gmail.com.
FAU - Borghetti, Paolo
AU  - Borghetti P
AD  - Department of Radiation Oncology, ASST Spedali Civili di Brescia, P.le Spedali 
      Civili 1, 25123 Brescia, Italy. Electronic address: paolobor82@yahoo.it.
FAU - Triggiani, Luca
AU  - Triggiani L
AD  - Universita degli Studi di Brescia, Department of Radiation Oncology, Brescia 
      University, P.le Spedali Civili 1, 25123 Brescia, Italy. Electronic address: 
      triggioluca@hotmail.it.
FAU - Alghisi, Alessandro
AU  - Alghisi A
AD  - Department of Radiation Oncology, Alessandro Manzoni Hospital, Lecco, Italy. 
      Electronic address: ale.alghisi@libero.it.
FAU - Costantino, Gianluca
AU  - Costantino G
AD  - Radiation Oncology Service, ASST Valcamonica Esine, Italy. Electronic address: 
      costantino.gianlu@gmail.com.
FAU - Bertagna, Francesco
AU  - Bertagna F
AD  - Nuclear Medicine Department, University of Brescia and Spedali Civili of Brescia, 
      Brescia, Italy. Electronic address: francesco.bertagna@unibs.it.
FAU - Giaj Levra, Niccolo
AU  - Giaj Levra N
AD  - Advanced Radiation Oncology Department, IRCCS Sacro Cuore Don Calabria Hospital, 
      Italy. Electronic address: gmnicco@yahoo.it.
FAU - Pegurri, Ludovica
AU  - Pegurri L
AD  - Department of Radiation Oncology, ASST Spedali Civili di Brescia, P.le Spedali 
      Civili 1, 25123 Brescia, Italy. Electronic address: ludovicapegurri@libero.it.
FAU - Magrini, Stefano Maria
AU  - Magrini SM
AD  - Universita degli Studi di Brescia, Department of Radiation Oncology, Brescia 
      University, P.le Spedali Civili 1, 25123 Brescia, Italy. Electronic address: 
      stefano.magrini@unibs.it.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20210803
PL  - Netherlands
TA  - Crit Rev Oncol Hematol
JT  - Critical reviews in oncology/hematology
JID - 8916049
SB  - IM
MH  - *Hodgkin Disease/radiotherapy
MH  - Humans
MH  - *Mediastinal Neoplasms/radiotherapy
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted
MH  - *Radiotherapy, Conformal
MH  - *Radiotherapy, Intensity-Modulated/adverse effects
OTO - NOTNLM
OT  - IMRT
OT  - cardiovascular
OT  - conformal
OT  - intensity modulated
OT  - lymphoma
OT  - mediastinal
OT  - radiotherapy
OT  - secondary cancer
EDAT- 2021/08/07 06:00
MHDA- 2021/11/16 06:00
CRDT- 2021/08/06 20:13
PHST- 2020/08/08 00:00 [received]
PHST- 2021/05/20 00:00 [revised]
PHST- 2021/07/28 00:00 [accepted]
PHST- 2021/08/07 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
PHST- 2021/08/06 20:13 [entrez]
AID - S1040-8428(21)00225-0 [pii]
AID - 10.1016/j.critrevonc.2021.103437 [doi]
PST - ppublish
SO  - Crit Rev Oncol Hematol. 2021 Nov;167:103437. doi: 
      10.1016/j.critrevonc.2021.103437. Epub 2021 Aug 3.