PMID- 34358763
OWN - NLM
STAT- MEDLINE
DCOM- 20211019
LR  - 20221003
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 236
DP  - 2021 Oct
TI  - Eveningness chronotype preference among individuals at clinical high risk for 
      psychosis.
PG  - 3-8
LID - S0920-9964(21)00308-X [pii]
LID - 10.1016/j.schres.2021.07.034 [doi]
AB  - BACKGROUND: Circadian rhythm disturbances are frequently implicated in psychosis. 
      Indeed, research has suggested several avenues by which circadian rhythms may 
      play a mechanistic role as well as contribute to clinical outcomes. Despite its 
      potential role as a risk factor, little is known about circadian rhythm 
      disruption among individuals at clinical high risk (CHR) for psychosis, clinical 
      correlates, or specificity to the psychosis risk syndrome. METHODS: Eighty-four 
      CHR, 74 individuals with depressive disorders (DD), and 101 non-psychiatric 
      controls (NPC) participated in structured clinical interviews and provided 
      self-reports of chronotype preference. Clinical (positive, negative, anxious, and 
      depressive symptoms) and social functioning outcomes were self-reported and/or 
      clinician-rated. Analyses of covariance controlling for demographics examined 
      group differences in chronotype preference, and partial Pearson correlations 
      evaluated associations with clinical/functional outcomes. RESULTS: Group 
      differences were observed (F(11, 246) = 8.05, p < .001) with CHR and DD 
      individuals indicating greater eveningness preference compared to NPC. A 
      follow-up sensitivity analysis examining CHR participants with (n = 25) and 
      without (n = 59) depressive disorders indicated no difference in chronotype 
      preference (F(10,72) = 0.00, p = .99). Greater eveningness preference was related 
      to greater negative symptoms (i.e., avolition; r = -0.25) and anxiety (r = -0.34) 
      among CHR individuals. CONCLUSIONS: CHR and DD display greater preference for 
      eveningness chronotype compared to NPC indicating the disruption is associated 
      with a range of mental health concerns, and not specific to the psychosis-risk 
      syndrome. However, comorbidity with DD did not appear to be driving the finding 
      in the CHR group. Further research may examine shared versus non-shared 
      underlying mechanisms contributing to chronotype preference across psychiatric 
      presentations.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Lunsford-Avery, Jessica R
AU  - Lunsford-Avery JR
AD  - Duke University School of Medicine, Department of Psychiatry and Behavioral 
      Sciences, Durham, NC, USA. Electronic address: jessica.r.avery@duke.edu.
FAU - Pelletier-Baldelli, Andrea
AU  - Pelletier-Baldelli A
AD  - University of North Carolina Chapel Hill, Department of Psychiatry, Chapel Hill, 
      NC, USA.
FAU - Korenic, Stephanie A
AU  - Korenic SA
AD  - Temple University, Department of Psychology, Philadelphia, PA, USA.
FAU - Schiffman, Jason
AU  - Schiffman J
AD  - University of Maryland Baltimore County, Department of Psychology, Baltimore, MD, 
      USA.
FAU - Ellman, Lauren M
AU  - Ellman LM
AD  - Temple University, Department of Psychology, Philadelphia, PA, USA.
FAU - Jackson, Leah
AU  - Jackson L
AD  - Duke University School of Medicine, Department of Psychiatry and Behavioral 
      Sciences, Durham, NC, USA.
FAU - Mittal, Vijay A
AU  - Mittal VA
AD  - Northwestern University, Department of Psychology, Evanston, IL, USA; 
      Northwestern University, Department of Psychiatry, Evanston, IL, USA; 
      Northwestern University, Institute for Policy Research, Evanston, IL, USA; 
      Northwestern University, Department of Medical Social Science, Evanston, IL, USA.
LA  - eng
GR  - R01 MH112613/MH/NIMH NIH HHS/United States
GR  - K23 MH108704/MH/NIMH NIH HHS/United States
GR  - R01 MH112612/MH/NIMH NIH HHS/United States
GR  - R34 MH110506/MH/NIMH NIH HHS/United States
GR  - T32 HD007376/HD/NICHD NIH HHS/United States
GR  - R01 MH116039/MH/NIMH NIH HHS/United States
GR  - R01 MH120091/MH/NIMH NIH HHS/United States
GR  - R01 MH120088/MH/NIMH NIH HHS/United States
GR  - T32 MH106440/MH/NIMH NIH HHS/United States
GR  - R01 MH112545/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20210804
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Anxiety
MH  - *Circadian Rhythm
MH  - Humans
MH  - *Psychotic Disorders/complications
MH  - Risk Factors
MH  - Self Report
MH  - Sleep
MH  - Surveys and Questionnaires
PMC - PMC8464500
MID - NIHMS1732025
OTO - NOTNLM
OT  - Chronotype
OT  - Circadian rhythms
OT  - Clinical high risk
OT  - Diurnal preference
OT  - Psychosis
OT  - Schizophrenia
COIS- Declaration of interest: none.
EDAT- 2021/08/07 06:00
MHDA- 2021/10/21 06:00
PMCR- 2022/10/01
CRDT- 2021/08/06 20:16
PHST- 2021/05/13 00:00 [received]
PHST- 2021/07/19 00:00 [revised]
PHST- 2021/07/25 00:00 [accepted]
PHST- 2021/08/07 06:00 [pubmed]
PHST- 2021/10/21 06:00 [medline]
PHST- 2021/08/06 20:16 [entrez]
PHST- 2022/10/01 00:00 [pmc-release]
AID - S0920-9964(21)00308-X [pii]
AID - 10.1016/j.schres.2021.07.034 [doi]
PST - ppublish
SO  - Schizophr Res. 2021 Oct;236:3-8. doi: 10.1016/j.schres.2021.07.034. Epub 2021 Aug 
      4.