PMID- 34359760
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210810
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 13
IP  - 15
DP  - 2021 Jul 31
TI  - Superficially Invasive Vulvar Squamous Cell Carcinoma: A 37-Year-Long Experience 
      of a Tertiary Referral Center.
LID - 10.3390/cancers13153859 [doi]
LID - 3859
AB  - Superficially, invasive vulvar squamous cell carcinoma (SISCCA) (FIGO stage IA) 
      is a rare subset of vulvar cancer defined as a single lesion measuring </=2 cm with 
      a depth of invasion of </=1.0 mm. This is a retrospective study performed on 48 
      patients with SISCCA, surgically treated between 1981 and 2018 at the S. Anna 
      Hospital, University of Turin, to evaluate pathological characteristics and 
      prognosis of these tumors. Ten patients (21%) recurred: seven (14%) as SISCCA and 
      three (7%) as deeply invasive carcinoma. One case with perineural invasion and 
      groin node metastasis at recurrence. No patient had groin lymph node metastases 
      at initial diagnosis. Site of SISCCA, type of surgery, status of surgical 
      margins, and histopathological features did not differ between recurrent and 
      non-recurrent patients. We observed a non-significant trend towards an increase 
      of recurrences in younger women (median age: 63 years vs. 70 years, p = 0.09), 
      while, surprisingly, smaller tumors (<12 mm) were significantly related to tumor 
      relapse (p = 0.03). Overall, SISCCA has a good long-term prognosis, regardless of 
      the pathological characteristics and the type of surgical treatment. We recommend 
      close follow-up, especially for younger patients and for small tumors, due to the 
      possibility of recurrence or re-occurrence even after years.
FAU - Preti, Mario
AU  - Preti M
AUID- ORCID: 0000-0002-1573-3114
AD  - Division of Gynecology and Obstetrics 1, Department of Surgical Sciences, "City 
      of Health and Science University Hospital", University of Turin, 10126 Turin, 
      Italy.
FAU - Borella, Fulvio
AU  - Borella F
AUID- ORCID: 0000-0001-8398-7557
AD  - Division of Gynecology and Obstetrics 1, Department of Surgical Sciences, "City 
      of Health and Science University Hospital", University of Turin, 10126 Turin, 
      Italy.
FAU - Gallio, Niccolo
AU  - Gallio N
AUID- ORCID: 0000-0002-3041-1201
AD  - Division of Gynecology and Obstetrics 1, Department of Surgical Sciences, "City 
      of Health and Science University Hospital", University of Turin, 10126 Turin, 
      Italy.
FAU - Bertero, Luca
AU  - Bertero L
AUID- ORCID: 0000-0001-9887-7668
AD  - Pathology Unit, Department of Medical Sciences, "City of Health and Science 
      University Hospital", University of Turin, 10126 Turin, Italy.
FAU - Heller, Debra Sandra
AU  - Heller DS
AD  - Rutgers-New Jersey Medical School, Newark, NJ 07103, USA.
FAU - Vieira-Baptista, Pedro
AU  - Vieira-Baptista P
AD  - Lower Genital Tract Unit, Centro Hospitalar de Sao Joao, 4200-319 Porto, 
      Portugal.
FAU - Cosma, Stefano
AU  - Cosma S
AUID- ORCID: 0000-0003-0563-0071
AD  - Division of Gynecology and Obstetrics 1, Department of Surgical Sciences, "City 
      of Health and Science University Hospital", University of Turin, 10126 Turin, 
      Italy.
FAU - Bevilacqua, Federica
AU  - Bevilacqua F
AD  - Division of Gynecology and Obstetrics 1, Department of Surgical Sciences, "City 
      of Health and Science University Hospital", University of Turin, 10126 Turin, 
      Italy.
FAU - Privitera, Sebastiana
AU  - Privitera S
AD  - Pathology Unit, Department of Medical Sciences, "City of Health and Science 
      University Hospital", University of Turin, 10126 Turin, Italy.
FAU - Micheletti, Leonardo
AU  - Micheletti L
AD  - Division of Gynecology and Obstetrics 1, Department of Surgical Sciences, "City 
      of Health and Science University Hospital", University of Turin, 10126 Turin, 
      Italy.
FAU - Benedetto, Chiara
AU  - Benedetto C
AD  - Division of Gynecology and Obstetrics 1, Department of Surgical Sciences, "City 
      of Health and Science University Hospital", University of Turin, 10126 Turin, 
      Italy.
LA  - eng
PT  - Journal Article
DEP - 20210731
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC8345506
OTO - NOTNLM
OT  - groin metastases
OT  - human papilloma virus
OT  - lichen sclerosus
OT  - perineural invasion
OT  - recurrence
OT  - superficially invasive vulvar squamous cell carcinoma
OT  - vulvar cancer
OT  - vulvar squamous intraepithelial lesion
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/08 06:00
MHDA- 2021/08/08 06:01
PMCR- 2021/07/31
CRDT- 2021/08/07 01:03
PHST- 2021/07/02 00:00 [received]
PHST- 2021/07/22 00:00 [revised]
PHST- 2021/07/26 00:00 [accepted]
PHST- 2021/08/07 01:03 [entrez]
PHST- 2021/08/08 06:00 [pubmed]
PHST- 2021/08/08 06:01 [medline]
PHST- 2021/07/31 00:00 [pmc-release]
AID - cancers13153859 [pii]
AID - cancers-13-03859 [pii]
AID - 10.3390/cancers13153859 [doi]
PST - epublish
SO  - Cancers (Basel). 2021 Jul 31;13(15):3859. doi: 10.3390/cancers13153859.