PMID- 34360538
OWN - NLM
STAT- MEDLINE
DCOM- 20210816
LR  - 20210816
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 15
DP  - 2021 Jul 21
TI  - Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions 
      Related to Caloric Restriction.
LID - 10.3390/ijms22157772 [doi]
LID - 7772
AB  - Type 2 diabetes (T2DM) and cardiovascular disease (CVD) are closely associated 
      and represent a key public health problem worldwide. An excess of adipose tissue, 
      NAFLD, and gut dysbiosis establish a vicious circle that leads to chronic 
      inflammation and oxidative stress. Caloric restriction (CR) is the most promising 
      nutritional approach capable of improving cardiometabolic health. However, 
      adherence to CR represents a barrier to patients and is the primary cause of 
      therapeutic failure. To overcome this problem, many different nutraceutical 
      strategies have been designed. Based on several data that have shown that CR 
      action is mediated by AMPK/SIRT1 activation, several nutraceutical compounds 
      capable of activating AMPK/SIRT1 signaling have been identified. In this review, 
      we summarize recent data on the possible role of berberine, resveratrol, 
      quercetin, and L-carnitine as CR-related nutrients. Additionally, we discuss the 
      limitations related to the use of these nutrients in the management of T2DM and 
      CVD.
FAU - Senesi, Pamela
AU  - Senesi P
AUID- ORCID: 0000-0003-0304-1564
AD  - Department of Biomedical Sciences for Health, Universita degli Studi di Milano, 
      20131 Milan, Italy.
AD  - Department of Endocrinology, Nutrition and Metabolic Diseases, IRCCS MultiMedica, 
      Sesto San Giovanni, 20099 Milan, Italy.
FAU - Ferrulli, Anna
AU  - Ferrulli A
AUID- ORCID: 0000-0002-8518-5547
AD  - Department of Biomedical Sciences for Health, Universita degli Studi di Milano, 
      20131 Milan, Italy.
AD  - Department of Endocrinology, Nutrition and Metabolic Diseases, IRCCS MultiMedica, 
      Sesto San Giovanni, 20099 Milan, Italy.
FAU - Luzi, Livio
AU  - Luzi L
AD  - Department of Biomedical Sciences for Health, Universita degli Studi di Milano, 
      20131 Milan, Italy.
AD  - Department of Endocrinology, Nutrition and Metabolic Diseases, IRCCS MultiMedica, 
      Sesto San Giovanni, 20099 Milan, Italy.
FAU - Terruzzi, Ileana
AU  - Terruzzi I
AD  - Department of Biomedical Sciences for Health, Universita degli Studi di Milano, 
      20131 Milan, Italy.
AD  - Department of Endocrinology, Nutrition and Metabolic Diseases, IRCCS MultiMedica, 
      Sesto San Giovanni, 20099 Milan, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210721
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Animals
MH  - *Caloric Restriction
MH  - Cardiovascular Diseases/*diet therapy
MH  - Diabetes Mellitus, Type 2/*diet therapy
MH  - Dietary Supplements/*analysis
MH  - Humans
PMC - PMC8345941
OTO - NOTNLM
OT  - L-carnitine
OT  - berberine
OT  - caloric restriction
OT  - cardiovascular diseases
OT  - diabetes
OT  - quercetin
OT  - resveratrol
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/08 06:00
MHDA- 2021/08/17 06:00
PMCR- 2021/07/21
CRDT- 2021/08/07 01:06
PHST- 2021/06/21 00:00 [received]
PHST- 2021/07/15 00:00 [revised]
PHST- 2021/07/18 00:00 [accepted]
PHST- 2021/08/07 01:06 [entrez]
PHST- 2021/08/08 06:00 [pubmed]
PHST- 2021/08/17 06:00 [medline]
PHST- 2021/07/21 00:00 [pmc-release]
AID - ijms22157772 [pii]
AID - ijms-22-07772 [pii]
AID - 10.3390/ijms22157772 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 Jul 21;22(15):7772. doi: 10.3390/ijms22157772.