PMID- 34361038
OWN - NLM
STAT- MEDLINE
DCOM- 20210908
LR  - 20210908
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 15
DP  - 2021 Jul 31
TI  - Probiotic-Induced Tolerogenic Dendritic Cells: A Novel Therapy for Inflammatory 
      Bowel Disease?
LID - 10.3390/ijms22158274 [doi]
LID - 8274
AB  - Inflammatory bowel diseases (IBDs) are immune-mediated, chronic relapsing 
      diseases with a rising prevalence worldwide in both adult and pediatric 
      populations. Treatment options for immune-mediated diseases, including IBDs, are 
      traditional steroids, immunomodulators, and biologics, none of which are capable 
      of inducing long-lasting remission in all patients. Dendritic cells (DCs) play a 
      fundamental role in inducing tolerance and regulating T cells and their 
      tolerogenic functions. Hence, modulation of intestinal mucosal immunity by DCs 
      could provide a novel, additional tool for the treatment of IBD. Recent evidence 
      indicates that probiotic bacteria might impact immunomodulation both in vitro and 
      in vivo by regulating DCs' maturation and producing tolerogenic DCs (tolDCs) 
      which, in turn, might dampen inflammation. In this review, we will discuss this 
      evidence and the mechanisms of action of probiotics and their metabolites in 
      inducing tolDCs in IBDs and some conditions associated with them.
FAU - Baradaran Ghavami, Shaghayegh
AU  - Baradaran Ghavami S
AD  - Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, 
      Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti 
      University of Medical Sciences, Tehran 19839-63113, Iran.
FAU - Asadzadeh Aghdaei, Hamid
AU  - Asadzadeh Aghdaei H
AUID- ORCID: 0000-0001-5589-8856
AD  - Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, 
      Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti 
      University of Medical Sciences, Tehran 19839-63113, Iran.
FAU - Sorrentino, Dario
AU  - Sorrentino D
AD  - IBD Center, Division of Gastroenterology, Virginia Tech Carilion School of 
      Medicine, 3 Riverside Circle, Roanoke, VA 24016, USA.
AD  - Department of Clinical and Experimental Medical Sciences, University of Udine 
      School of Medicine, 33100 Udine, Italy.
FAU - Shahrokh, Shabnam
AU  - Shahrokh S
AD  - Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, 
      Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti 
      University of Medical Sciences, Tehran 19839-63113, Iran.
FAU - Farmani, Maryam
AU  - Farmani M
AUID- ORCID: 0000-0001-9941-733X
AD  - Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, 
      Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti 
      University of Medical Sciences, Tehran 19839-63113, Iran.
FAU - Ashrafian, Fatemeh
AU  - Ashrafian F
AUID- ORCID: 0000-0001-8260-100X
AD  - Microbiology Research Center, Pasteur Institute of Iran, Tehran 13169-43551, 
      Iran.
FAU - Dore, Maria Pina
AU  - Dore MP
AUID- ORCID: 0000-0001-7305-3531
AD  - Department di Medical, Surgical and Experimental Sciences, University of Sassari 
      School of Medicine, 07100 Sassari, Italy.
FAU - Keshavarz Azizi Raftar, Shahrbanoo
AU  - Keshavarz Azizi Raftar S
AD  - Microbiology Research Center, Pasteur Institute of Iran, Tehran 13169-43551, 
      Iran.
FAU - Mobin Khoramjoo, Seyed
AU  - Mobin Khoramjoo S
AD  - Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, 
      Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti 
      University of Medical Sciences, Tehran 19839-63113, Iran.
FAU - Zali, Mohammad Reza
AU  - Zali MR
AD  - Gastroenterology and Liver Diseases Research Center, Research Institute for 
      Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical 
      Sciences, Tehran 19839-63113, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210731
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Inflammatory Bowel Diseases/diet therapy/*immunology/microbiology
MH  - Intestinal Mucosa/cytology/immunology
MH  - Probiotics/*therapeutic use
PMC - PMC8348973
OTO - NOTNLM
OT  - Crohn's disease
OT  - dendritic cells
OT  - inflammatory bowel diseases
OT  - mucosal tolerance
OT  - probiotics
OT  - ulcerative colitis
COIS- There are no conflict of interest to declare.
EDAT- 2021/08/08 06:00
MHDA- 2021/09/09 06:00
PMCR- 2021/07/31
CRDT- 2021/08/07 01:08
PHST- 2021/06/24 00:00 [received]
PHST- 2021/07/22 00:00 [revised]
PHST- 2021/07/24 00:00 [accepted]
PHST- 2021/08/07 01:08 [entrez]
PHST- 2021/08/08 06:00 [pubmed]
PHST- 2021/09/09 06:00 [medline]
PHST- 2021/07/31 00:00 [pmc-release]
AID - ijms22158274 [pii]
AID - ijms-22-08274 [pii]
AID - 10.3390/ijms22158274 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 Jul 31;22(15):8274. doi: 10.3390/ijms22158274.