PMID- 34361114
OWN - NLM
STAT- MEDLINE
DCOM- 20210813
LR  - 20210813
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 15
DP  - 2021 Aug 3
TI  - Quercetin Administration Suppresses the Cytokine Storm in Myeloid and 
      Plasmacytoid Dendritic Cells.
LID - 10.3390/ijms22158349 [doi]
LID - 8349
AB  - Dendritic cells (DCs) can be divided by lineage into myeloid dendritic cells 
      (mDCs) and plasmacytoid dendritic cells (pDCs). They both are present in mucosal 
      tissues and regulate the immune response by secreting chemokines and cytokines. 
      Inflammatory bowel diseases (IBDs) are characterized by a leaky intestinal 
      barrier and the consequent translocation of bacterial lipopolysaccharide (LPS) to 
      the basolateral side. This results in DCs activation, but the response of pDCs is 
      still poorly characterized. In the present study, we compared mDCs and pDCs 
      responses to LPS administration. We present a broad panel of DCs secreted 
      factors, including cytokines, chemokines, and growth factors. Our recent studies 
      demonstrated the anti-inflammatory effects of quercetin administration, but to 
      date, there is no evidence about quercetin's effects on pDCs. The results of the 
      present study demonstrate that pDCs can respond to LPS and that quercetin 
      exposure modulates soluble factors release through the same molecular pathway 
      used by mDCs (Slpi, Hmox1, and AP-1).
FAU - Verna, Giulio
AU  - Verna G
AUID- ORCID: 0000-0001-8329-0370
AD  - Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy.
FAU - Liso, Marina
AU  - Liso M
AUID- ORCID: 0000-0002-8766-1869
AD  - National Institute of Gastroenterology "S. de Bellis", Institute of Research, 
      70013 Castellana Grotte, Italy.
FAU - Cavalcanti, Elisabetta
AU  - Cavalcanti E
AUID- ORCID: 0000-0003-2952-0053
AD  - National Institute of Gastroenterology "S. de Bellis", Institute of Research, 
      70013 Castellana Grotte, Italy.
FAU - Bianco, Giusy
AU  - Bianco G
AD  - National Institute of Gastroenterology "S. de Bellis", Institute of Research, 
      70013 Castellana Grotte, Italy.
FAU - Di Sarno, Veronica
AU  - Di Sarno V
AD  - Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy.
FAU - Santino, Angelo
AU  - Santino A
AUID- ORCID: 0000-0002-3348-0747
AD  - Unit of Lecce, Institute of Sciences of Food Production C.N.R., 73100 Lecce, 
      Italy.
FAU - Campiglia, Pietro
AU  - Campiglia P
AUID- ORCID: 0000-0002-1069-2181
AD  - Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy.
FAU - Chieppa, Marcello
AU  - Chieppa M
AUID- ORCID: 0000-0001-9819-0823
AD  - National Institute of Gastroenterology "S. de Bellis", Institute of Research, 
      70013 Castellana Grotte, Italy.
LA  - eng
GR  - GR-2011-02347991/Ministero della Salute/
GR  - Ricerca Corrente 2020 IRCCS "S. de Bellis"/Ministero della Salute/
GR  - Associazione Malattie Infiammatorie Croniche Intestinali/M.I.Cro/
GR  - SiCURA "Soluzioni Innovative per la gestione del paziente e il follow up 
      terapeutico della Colite UlceRosA" (KC3U5Y1)/Regione Puglia/
GR  - PO FESR 2014-2020; "Piattaforme tecnologiche di ricerca collaborativa per la 
      lotta alle patologie oncologiche"/Regione Campania/
PT  - Journal Article
DEP - 20210803
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Antioxidants)
RN  - 0 (Cytokines)
RN  - 9IKM0I5T1E (Quercetin)
SB  - IM
MH  - Animals
MH  - Antioxidants/administration & dosage/*pharmacology
MH  - Cells, Cultured
MH  - Cytokine Release Syndrome/*drug therapy/immunology/metabolism/pathology
MH  - Cytokines/drug effects/*metabolism
MH  - Dendritic Cells/cytology/*drug effects/immunology/metabolism
MH  - Mice
MH  - Myeloid Cells/cytology/*drug effects/immunology/metabolism
MH  - Quercetin/administration & dosage/*pharmacology
PMC - PMC8348289
OTO - NOTNLM
OT  - cytokines
OT  - dendritic cells
OT  - plasmacytoid
OT  - quercetin
OT  - slpi
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/08 06:00
MHDA- 2021/08/14 06:00
PMCR- 2021/08/03
CRDT- 2021/08/07 01:09
PHST- 2021/07/12 00:00 [received]
PHST- 2021/07/30 00:00 [revised]
PHST- 2021/07/30 00:00 [accepted]
PHST- 2021/08/07 01:09 [entrez]
PHST- 2021/08/08 06:00 [pubmed]
PHST- 2021/08/14 06:00 [medline]
PHST- 2021/08/03 00:00 [pmc-release]
AID - ijms22158349 [pii]
AID - ijms-22-08349 [pii]
AID - 10.3390/ijms22158349 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 Aug 3;22(15):8349. doi: 10.3390/ijms22158349.