PMID- 34363120
OWN - NLM
STAT- MEDLINE
DCOM- 20220113
LR  - 20220113
IS  - 1432-2099 (Electronic)
IS  - 0301-634X (Linking)
VI  - 60
IP  - 4
DP  - 2021 Nov
TI  - Dosimetric study of a hybrid plan technique for external beam radiotherapy in 
      patients with cervical cancer.
PG  - 653-662
LID - 10.1007/s00411-021-00931-9 [doi]
AB  - The aim of this study was to investigate the effect of a hybrid technique which 
      results from combining intensity modulated radiotherapy (IMRT) and volumetric 
      modulated arc therapy (VMAT) for the treatment of cervical cancer patients. Plans 
      made with the hybrid technique and pure IMRT and VMAT were retrospectively 
      compared in 20 patients with cervical cancer at different stages. All plans were 
      made using the same contours based on the original computed tomography (CT) 
      scans. Conformity (CI) and homogeneity (HI) indices of the planning target 
      volumes (PTVs) were calculated for each technique in order to evaluate plan 
      quality. All techniques were compared in terms of dose to organs at risk (OARs), 
      number of monitor units (MUs) and treatment time. It turned out that plans made 
      with the hybrid technique had improved dose conformity and homogeneity compared 
      to plans made only with IMRT and VMAT (p < 0.001). Regarding the OARs, the 
      maximum dose (D(max)) delivered to the bladder, rectum and femoral heads was 
      lower for the hybrid plans compared to the IMRT and VMAT plans (p < 0.001). The 
      volumes irradiated to doses of 50 Gy (V(50Gy)) for rectum, bladder and bowel were 
      lower for the hybrid plans (p < 0.001, p = 0.002). Furthermore, the treatment 
      time and MU values for the hybrid plans were found to be between of the values 
      for the IMRT and VMAT plans. It is concluded that, as compared to IMRT and VMAT 
      plans, the hybrid plan technique allowed a better conformity and homogeneity for 
      the dose distribution in the PTV and a dose reduction to the OARs.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Martin-Tovar, E A
AU  - Martin-Tovar EA
AUID- ORCID: 0000-0002-8259-5479
AD  - Division de Oncologia y Uronefrologia, Departamento de Radioterapia, Unidad 
      Medica de Alta Especialidad, Hospital de Especialidades del Centro Medico 
      Nacional "Ignacio Garcia Tellez", Instituto Mexicano del Seguro Social, CP 97150, 
      Merida, Yucatan, Mexico. enrique.martin.tovar@gmail.com.
FAU - Badillo-Alvarado, A H
AU  - Badillo-Alvarado AH
AD  - Division de Oncologia y Uronefrologia, Departamento de Radioterapia, Unidad 
      Medica de Alta Especialidad, Hospital de Especialidades del Centro Medico 
      Nacional "Ignacio Garcia Tellez", Instituto Mexicano del Seguro Social, CP 97150, 
      Merida, Yucatan, Mexico.
FAU - Cocom-Poot, L E
AU  - Cocom-Poot LE
AD  - Division de Oncologia y Uronefrologia, Departamento de Radioterapia, Unidad 
      Medica de Alta Especialidad, Hospital de Especialidades del Centro Medico 
      Nacional "Ignacio Garcia Tellez", Instituto Mexicano del Seguro Social, CP 97150, 
      Merida, Yucatan, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20210806
PL  - Germany
TA  - Radiat Environ Biophys
JT  - Radiation and environmental biophysics
JID - 0415677
SB  - IM
MH  - Female
MH  - Humans
MH  - Organs at Risk
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted
MH  - *Radiotherapy, Intensity-Modulated
MH  - Retrospective Studies
MH  - *Uterine Cervical Neoplasms/radiotherapy
OTO - NOTNLM
OT  - Cervical cancer
OT  - Hybrid
OT  - IMRT
OT  - Radiotherapy
OT  - VMAT
EDAT- 2021/08/08 06:00
MHDA- 2022/01/14 06:00
CRDT- 2021/08/07 06:20
PHST- 2021/05/10 00:00 [received]
PHST- 2021/07/31 00:00 [accepted]
PHST- 2021/08/08 06:00 [pubmed]
PHST- 2022/01/14 06:00 [medline]
PHST- 2021/08/07 06:20 [entrez]
AID - 10.1007/s00411-021-00931-9 [pii]
AID - 10.1007/s00411-021-00931-9 [doi]
PST - ppublish
SO  - Radiat Environ Biophys. 2021 Nov;60(4):653-662. doi: 10.1007/s00411-021-00931-9. 
      Epub 2021 Aug 6.