PMID- 34363875
OWN - NLM
STAT- MEDLINE
DCOM- 20211230
LR  - 20211230
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 156
DP  - 2021 Oct
TI  - Perfluorooctane sulfonate and bisphenol A induce a similar level of mast cell 
      activation via a common signaling pathway, Fyn-Lyn-Syk activation.
PG  - 112478
LID - S0278-6915(21)00511-1 [pii]
LID - 10.1016/j.fct.2021.112478 [doi]
AB  - Perfluoroalkyl compounds (PFCs) as food contaminants are widely distributed 
      persistent organic pollutants (POPs) and have been suggested to induce immune 
      dysfunction. However, their effects on immune function are not conclusive. Mast 
      cells play a central role in allergic and non-allergic inflammatory responses. 
      Therefore, we have examined the effects of PFCs (PFHxS, PFOA, PFOS) on mast 
      cell-mediated inflammatory responses using in vitro mouse bone marrow-derived 
      mast cells (BMMCs) and human mast cells (HMC-1) and in vivo mice model. The 
      effects of PFCs were compared with those of bisphenol A (BPA), a well-studied 
      environmental pollutant. Among PFCs tested, PFOS had the highest effects. Both 
      PFOS and BPA increased degranulation and production of inflammatory eicosanoids 
      in mast cells at a similar level, which subsequently led to increased skin edema 
      and serum LTC(4) and PGD(2) in mice. Both PFOS and BPA increased not only 
      downstream signaling (PLCgamma1, AKT, ERK), but also upstream signaling (Fyn, Lyn, 
      Syk/LAT) in mast cells. Taken together, PFOS and BPA induce mast cell-mediated 
      inflammatory responses via a common signaling pathways. Our results may help 
      establish the scientific basis for understanding the etiology of mast 
      cell-mediated inflammatory responses and improve the immune dysfunction risk 
      assessment for emerging POPs such as PFCs.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Park, Sung-Joon
AU  - Park SJ
AD  - Department of Pharmacology/Toxicology, School of Medicine, Catholic University of 
      Daegu, Daegu, Republic of Korea.
FAU - Sim, Kyeong Hwa
AU  - Sim KH
AD  - Department of Pharmacology/Toxicology, School of Medicine, Catholic University of 
      Daegu, Daegu, Republic of Korea.
FAU - Shrestha, Prafulla
AU  - Shrestha P
AD  - Department of Pharmacology/Toxicology, School of Medicine, Catholic University of 
      Daegu, Daegu, Republic of Korea.
FAU - Yang, Jae-Ho
AU  - Yang JH
AD  - Department of Pharmacology/Toxicology, School of Medicine, Catholic University of 
      Daegu, Daegu, Republic of Korea.
FAU - Lee, Youn Ju
AU  - Lee YJ
AD  - Department of Pharmacology/Toxicology, School of Medicine, Catholic University of 
      Daegu, Daegu, Republic of Korea. Electronic address: whrytn4337@cu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20210804
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Fluorocarbons)
RN  - 0 (Phenols)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
RN  - EC 2.7.10.2 (Fyn protein, mouse)
RN  - EC 2.7.10.2 (Proto-Oncogene Proteins c-fyn)
RN  - EC 2.7.10.2 (Syk Kinase)
RN  - EC 2.7.10.2 (Syk protein, mouse)
RN  - EC 2.7.10.2 (lyn protein-tyrosine kinase)
RN  - EC 2.7.10.2 (src-Family Kinases)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Alkanesulfonic Acids/*toxicity
MH  - Animals
MH  - Benzhydryl Compounds/*toxicity
MH  - Fluorocarbons/*toxicity
MH  - Humans
MH  - Mast Cells/*drug effects
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred ICR
MH  - Phenols/*toxicity
MH  - Proto-Oncogene Proteins c-fyn/*metabolism
MH  - Signal Transduction/*drug effects
MH  - Syk Kinase/*metabolism
MH  - src-Family Kinases/*metabolism
OTO - NOTNLM
OT  - Bisphenol A
OT  - Inflammation
OT  - Mast cell
OT  - Perfluorooctane sulfonate
OT  - Syk
EDAT- 2021/08/08 06:00
MHDA- 2021/12/31 06:00
CRDT- 2021/08/07 20:12
PHST- 2021/04/21 00:00 [received]
PHST- 2021/07/31 00:00 [revised]
PHST- 2021/08/03 00:00 [accepted]
PHST- 2021/08/08 06:00 [pubmed]
PHST- 2021/12/31 06:00 [medline]
PHST- 2021/08/07 20:12 [entrez]
AID - S0278-6915(21)00511-1 [pii]
AID - 10.1016/j.fct.2021.112478 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2021 Oct;156:112478. doi: 10.1016/j.fct.2021.112478. Epub 2021 
      Aug 4.