PMID- 34364991
OWN - NLM
STAT- MEDLINE
DCOM- 20211210
LR  - 20221207
IS  - 1535-7732 (Electronic)
IS  - 1051-0443 (Linking)
VI  - 32
IP  - 11
DP  - 2021 Nov
TI  - Endovascular Celiac Denervation for Glycemic Control in Patients with Type 2 
      Diabetes Mellitus.
PG  - 1519-1528.e2
LID - S1051-0443(21)01274-4 [pii]
LID - 10.1016/j.jvir.2021.07.023 [doi]
AB  - PURPOSE: To investigate the safety and efficacy of catheter-based endovascular 
      denervation (EDN) at the celiac artery and abdominal aorta around the celiac 
      artery on glycemic control in patients with type 2 diabetes mellitus (T2DM). 
      MATERIALS AND METHODS: With a novel catheter system, EDN was conducted at the 
      celiac artery along with the abdominal aorta around the celiac artery in patients 
      with T2DM whose glycosylated hemoglobin (HbA1c) level was >7.5%. The primary 
      outcome was HbA1c level at 6 months. Other outcomes included safety, oral glucose 
      tolerance test, homeostasis model assessment of insulin resistance (HOMA-IR), 
      fasting plasma glucose (FPG) level, 2-hour postprandial plasma glucose (2hPG) 
      level, and C-peptide test. RESULTS: A total of 11 subjects were included for 
      analysis. The technical success was 100%, and no severe treatment-related adverse 
      events or major complications were observed. Both HbA1c level and HOMA-IR were 
      significantly reduced at 6 months (9.9% vs 8.0%, P = .005; 13.3 vs 6.0, P = 
      .016). Decreases in FPG and 2hPG levels were observed (227.2 vs 181.8 mg/dL, P < 
      .001; 322.2 vs 205.2 mg/dL, P = .001). The C-peptide test indicated improved 
      beta-cell function (area under the curve, 0.23 vs 0.28 pmol/mL, P = .046). A 
      reduction of daily insulin injection (P = .02) and improvement of liver function 
      (alanine aminotransferase, P = .014; gamma-glutamyl transpeptidase, P = .021) were 
      also observed. CONCLUSIONS: EDN in the celiac artery and abdominal aorta around 
      the celiac artery elicited a clinically significant improvement in glycemic 
      control and insulin resistance in patients with T2DM, with good tolerability as 
      demonstrated by 6-month follow-up.
CI  - Copyright (c) 2021 SIR. Published by Elsevier Inc. All rights reserved.
FAU - Pan, Tao
AU  - Pan T
AD  - Center of Interventional Radiology and Vascular Surgery, Department of Radiology, 
      Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
FAU - Li, Ling
AU  - Li L
AD  - Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast 
      University, Nanjing, China; Institute of Pancreas, Southeast University, Nanjing, 
      China.
FAU - Wei, Qiong
AU  - Wei Q
AD  - Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast 
      University, Nanjing, China; Institute of Pancreas, Southeast University, Nanjing, 
      China.
FAU - Wang, Zhi
AU  - Wang Z
AD  - Center of Interventional Radiology and Vascular Surgery, Department of Radiology, 
      Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
FAU - Zhang, Qi
AU  - Zhang Q
AD  - Center of Interventional Radiology and Vascular Surgery, Department of Radiology, 
      Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
FAU - Qian, Yue
AU  - Qian Y
AD  - Department of Anesthesiology, Nanjing Drum Tower Hospital, Medical School of 
      Nanjing University, Nanjing, China.
FAU - Li, Rui
AU  - Li R
AD  - Center of Interventional Radiology and Vascular Surgery, Department of Radiology, 
      Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
FAU - Liu, De-Chen
AU  - Liu DC
AD  - Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast 
      University, Nanjing, China; Department of Clinical Science and Research, Zhongda 
      Hospital, School of Medicine, Southeast University, Nanjing, China.
FAU - Wang, Yao
AU  - Wang Y
AD  - Department of Clinical Science and Research, Zhongda Hospital, School of 
      Medicine, Southeast University, Nanjing, China.
FAU - Sun, Zi-Lin
AU  - Sun ZL
AD  - Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast 
      University, Nanjing, China.
FAU - Teng, Gao-Jun
AU  - Teng GJ
AD  - Center of Interventional Radiology and Vascular Surgery, Department of Radiology, 
      Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China. 
      Electronic address: gjteng@seu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210806
PL  - United States
TA  - J Vasc Interv Radiol
JT  - Journal of vascular and interventional radiology : JVIR
JID - 9203369
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
SB  - IM
MH  - Blood Glucose
MH  - Denervation
MH  - *Diabetes Mellitus, Type 2
MH  - Glycated Hemoglobin
MH  - Glycemic Control
MH  - Humans
MH  - Insulin
MH  - *Insulin Resistance
EDAT- 2021/08/09 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/08/08 20:36
PHST- 2021/04/26 00:00 [received]
PHST- 2021/07/16 00:00 [revised]
PHST- 2021/07/23 00:00 [accepted]
PHST- 2021/08/09 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/08/08 20:36 [entrez]
AID - S1051-0443(21)01274-4 [pii]
AID - 10.1016/j.jvir.2021.07.023 [doi]
PST - ppublish
SO  - J Vasc Interv Radiol. 2021 Nov;32(11):1519-1528.e2. doi: 
      10.1016/j.jvir.2021.07.023. Epub 2021 Aug 6.