PMID- 34365521
OWN - NLM
STAT- MEDLINE
DCOM- 20210922
LR  - 20220218
IS  - 1420-9071 (Electronic)
IS  - 1420-682X (Print)
IS  - 1420-682X (Linking)
VI  - 78
IP  - 17-18
DP  - 2021 Sep
TI  - IL-36 cytokines in inflammatory and malignant diseases: not the new kid on the 
      block anymore.
PG  - 6215-6227
LID - 10.1007/s00018-021-03909-4 [doi]
AB  - The IL-36 family of cytokines were first identified in 2000 based on their 
      sequence homology to IL-1 cytokines. Over subsequent years, the ability of these 
      cytokines to either agonise or antagonise an IL-1R homologue, now known as the 
      IL-36 Receptor (IL-36R), was identified and these cytokines went through several 
      cycles of renaming with the current nomenclature being proposed in 2010. Despite 
      being identified over 20 years ago, it is only during the last decade that the 
      function of these cytokines in health and disease has really begun to be 
      appreciated, with both homeostatic functions in wound healing and response to 
      infection, as well as pathological functions now ascribed. In the disease 
      context, over activation of IL-36 has now been associated with many inflammatory 
      diseases including Psoriasis and inflammatory bowel diseases, with roles in 
      cancer also now being investigated. This review summarises the current knowledge 
      of IL-36 biology, its role in inflammatory diseases and focuses on an emerging 
      role for IL-36 in cancer.
CI  - (c) 2021. The Author(s).
FAU - Byrne, James
AU  - Byrne J
AD  - Department of Pathology, Cork University Hospital, University College Cork, 
      Clinical Sciences Building, Cork, Ireland.
FAU - Baker, Kevin
AU  - Baker K
AD  - Department of Pathology, Cork University Hospital, University College Cork, 
      Clinical Sciences Building, Cork, Ireland.
FAU - Houston, Aileen
AU  - Houston A
AD  - Department of Medicine, University College Cork, Cork, Ireland.
AD  - APC Microbiome Ireland, University College Cork, Cork, Ireland.
FAU - Brint, Elizabeth
AU  - Brint E
AUID- ORCID: 0000-0001-9214-149X
AD  - Department of Pathology, Cork University Hospital, University College Cork, 
      Clinical Sciences Building, Cork, Ireland. e.brint@ucc.ie.
AD  - APC Microbiome Ireland, University College Cork, Cork, Ireland. e.brint@ucc.ie.
LA  - eng
GR  - GOIPG/2018/2974/Irish Research Council/
PT  - Journal Article
PT  - Review
DEP - 20210807
PL  - Switzerland
TA  - Cell Mol Life Sci
JT  - Cellular and molecular life sciences : CMLS
JID - 9705402
RN  - 0 (IL36A protein, human)
RN  - 0 (IL36RN protein, human)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukins)
SB  - IM
MH  - Humans
MH  - Immunity, Innate
MH  - Inflammatory Bowel Diseases/metabolism/*pathology
MH  - Interleukin-1/chemistry/genetics/*metabolism
MH  - Interleukins/genetics/metabolism
MH  - Joint Diseases/metabolism/pathology
MH  - Neoplasms/metabolism/*pathology
MH  - Neurodegenerative Diseases/metabolism/pathology
MH  - Psoriasis/metabolism/pathology
MH  - Signal Transduction
PMC - PMC8429149
OTO - NOTNLM
OT  - Cancer
OT  - Cytokine
OT  - Disease
OT  - IL-1 family
OT  - Inflammation
OT  - Interleukin-36
COIS- The authors have no competing of interests to declare.
EDAT- 2021/08/09 06:00
MHDA- 2021/09/23 06:00
PMCR- 2021/08/07
CRDT- 2021/08/08 21:01
PHST- 2021/06/10 00:00 [received]
PHST- 2021/07/29 00:00 [accepted]
PHST- 2021/07/27 00:00 [revised]
PHST- 2021/08/09 06:00 [pubmed]
PHST- 2021/09/23 06:00 [medline]
PHST- 2021/08/08 21:01 [entrez]
PHST- 2021/08/07 00:00 [pmc-release]
AID - 10.1007/s00018-021-03909-4 [pii]
AID - 3909 [pii]
AID - 10.1007/s00018-021-03909-4 [doi]
PST - ppublish
SO  - Cell Mol Life Sci. 2021 Sep;78(17-18):6215-6227. doi: 10.1007/s00018-021-03909-4. 
      Epub 2021 Aug 7.