PMID- 34365603
OWN - NLM
STAT- MEDLINE
DCOM- 20220110
LR  - 20220110
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 29
IP  - 2
DP  - 2022 Jan
TI  - Quercetin improves the adipose inflammatory response and insulin signaling to 
      reduce "real-world" particulate matter-induced insulin resistance.
PG  - 2146-2157
LID - 10.1007/s11356-021-15829-8 [doi]
AB  - Numerous epidemiological data and experimental studies support a strong link 
      between fine particulate matter (less than 2.5 mm in aerodynamic diameter, 
      PM(2.5)) exposure and the development of insulin resistance/type 2 diabetes 
      mellitus (T2DM). Quercetin (Que), a flavonoid compound with anti-inflammatory 
      effects, has been confirmed to improve glucose metabolic disorders in rodents and 
      humans. In this study, we investigated the underlying mechanisms of particulate 
      matter (PM)-induced glucose metabolic disorder and subsequently examined the 
      protective effect and mechanism of quercetin supplementation. Male C57BL/6 mice 
      in the control group and PM group were exposed to ambient filtered air (FA) or PM 
      (6 h/day, 7 days/week) for 18 weeks. Mice in the Que group were exposed to PM for 
      18 weeks and administered Que (50 or 100 mg/kg bw). Glucose tolerance, insulin 
      sensitivity, and systemic and visceral white adipose tissue (vWAT) inflammatory 
      responses were measured. The expression of proteins involved in insulin signal 
      transduction in vWAT was assessed. Chronic PM exposure caused systemic and vWAT 
      inflammation characterized by an increase in serum IL-6 and TNF-alpha levels and 
      increased vWAT macrophage filtration, triggering NLRP3 inflammasome activation, 
      impairing the classic glucose metabolism signal in vWAT, and inducing whole-body 
      insulin resistance. Moreover, Que administration significantly alleviated 
      systemic and vWAT inflammation, abolished NLRP3 inflammasome activation, and 
      improved signaling abnormalities characteristic of insulin resistance in vWAT and 
      adipocytes. Based on these findings, chronic PM exposure activated the NLRP3 
      inflammasome and subsequently caused systemic and WAT inflammation and impaired 
      insulin signaling in vWAT and adipocytes. Most importantly, Que administration 
      inhibited NLRP3 inflammasome-mediated inflammation and insulin signaling in vWAT 
      to improve these adverse effects.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Jiang, Jinjin
AU  - Jiang J
AD  - Jiangsu Vocational College of Medicine, Yancheng, Jiangsu Province, People's 
      Republic of China.
FAU - Zhang, Guofu
AU  - Zhang G
AD  - School of Public Health, Xinxiang Medical University, Xinxiang, People's Republic 
      of China.
FAU - Yu, Min
AU  - Yu M
AD  - Jiangsu Vocational College of Medicine, Yancheng, Jiangsu Province, People's 
      Republic of China.
FAU - Gu, Juan
AU  - Gu J
AD  - Jiangsu Vocational College of Medicine, Yancheng, Jiangsu Province, People's 
      Republic of China.
FAU - Zheng, Yang
AU  - Zheng Y
AD  - Jiangsu Vocational College of Medicine, Yancheng, Jiangsu Province, People's 
      Republic of China.
FAU - Sun, Jinxia
AU  - Sun J
AD  - Jiangsu Vocational College of Medicine, Yancheng, Jiangsu Province, People's 
      Republic of China.
FAU - Ding, Shibin
AU  - Ding S
AUID- ORCID: 0000-0003-1341-3595
AD  - Jiangsu Vocational College of Medicine, Yancheng, Jiangsu Province, People's 
      Republic of China. dingshibin@163.com.
LA  - eng
PT  - Journal Article
DEP - 20210807
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Insulin)
RN  - 0 (Particulate Matter)
RN  - 9IKM0I5T1E (Quercetin)
SB  - IM
MH  - Animals
MH  - *Diabetes Mellitus, Type 2
MH  - Insulin
MH  - *Insulin Resistance
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Particulate Matter
MH  - Quercetin/pharmacology
MH  - Signal Transduction
OTO - NOTNLM
OT  - Inflammation
OT  - Insulin resistance
OT  - NLRP3 inflammasome
OT  - Particulate matter
OT  - Quercetin
OT  - Visceral adipose tissue
EDAT- 2021/08/09 06:00
MHDA- 2022/01/11 06:00
CRDT- 2021/08/08 21:04
PHST- 2021/02/16 00:00 [received]
PHST- 2021/07/31 00:00 [accepted]
PHST- 2021/08/09 06:00 [pubmed]
PHST- 2022/01/11 06:00 [medline]
PHST- 2021/08/08 21:04 [entrez]
AID - 10.1007/s11356-021-15829-8 [pii]
AID - 10.1007/s11356-021-15829-8 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2022 Jan;29(2):2146-2157. doi: 
      10.1007/s11356-021-15829-8. Epub 2021 Aug 7.