PMID- 34367700
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210810
IS  - 2090-6501 (Print)
IS  - 2090-651X (Electronic)
IS  - 2090-651X (Linking)
VI  - 2021
DP  - 2021
TI  - Multiple Endocrine Neoplasia Type 1 with Concomitant Existence of Malignant 
      Insulinoma: A Rare Finding.
PG  - 8842667
LID - 10.1155/2021/8842667 [doi]
LID - 8842667
AB  - Multiple endocrine neoplasia type 1 (MEN1) is a rare syndrome of autosomal 
      dominant inheritance defined by co-occurrence of two or more tumors originating 
      from the parathyroid gland, pancreatic islet cells, and/or anterior pituitary. 
      Insulinoma which has an incidence of 0.4% is a rare pancreatic neuroendocrine 
      tumor. Malignant insulinoma is extremely rare, while primary hyperparathyroidism 
      is a common occurrence in MEN1. We present a case of MEN1 syndrome with 2.6 cm 
      insulinoma in the pancreatic head and parathyroid adenoma in a 56-year-old female 
      who presented with symptoms suggestive of hypoglycemia like multiple episodes of 
      loss of consciousness for four years. Classical pancreaticoduodenectomy was 
      carried out, and the postoperative period was uneventful. Later, subtotal 
      parathyroidectomy was performed, which showed parathyroid adenoma. Patients 
      presenting with features of hypoglycemia should be vigilantly assessed for the 
      presence of a sinister pathology.
CI  - Copyright (c) 2021 Randhir Sagar Yadav et al.
FAU - Yadav, Randhir Sagar
AU  - Yadav RS
AUID- ORCID: 0000-0003-4075-3544
AD  - Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, 
      Kathmandu, Nepal.
FAU - Pokharel, Ashik
AU  - Pokharel A
AD  - Department of Gastrointestinal and General Surgery, Tribhuvan University Teaching 
      Hospital, Kathmandu, Nepal.
FAU - Gaire, Deepshikha
AU  - Gaire D
AD  - Department of Pathology, Tribhuvan University Teaching Hospital, Kathmandu, 
      Nepal.
FAU - Shrestha, Shumneva
AU  - Shrestha S
AUID- ORCID: 0000-0001-7368-7884
AD  - Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, 
      Kathmandu, Nepal.
FAU - Pokharel, Ashbita
AU  - Pokharel A
AD  - Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, 
      Kathmandu, Nepal.
FAU - Pradhan, Sumita
AU  - Pradhan S
AD  - Department of Gastrointestinal and General Surgery, Tribhuvan University Teaching 
      Hospital, Kathmandu, Nepal.
FAU - Kansakar, Prasan Bir Singh
AU  - Kansakar PBS
AD  - Department of Gastrointestinal and General Surgery, Tribhuvan University Teaching 
      Hospital, Kathmandu, Nepal.
LA  - eng
PT  - Case Reports
DEP - 20210728
PL  - United States
TA  - Case Rep Endocrinol
JT  - Case reports in endocrinology
JID - 101576457
PMC - PMC8337156
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2021/08/10 06:00
MHDA- 2021/08/10 06:01
PMCR- 2021/07/28
CRDT- 2021/08/09 06:36
PHST- 2020/08/27 00:00 [received]
PHST- 2021/06/11 00:00 [revised]
PHST- 2021/07/23 00:00 [accepted]
PHST- 2021/08/09 06:36 [entrez]
PHST- 2021/08/10 06:00 [pubmed]
PHST- 2021/08/10 06:01 [medline]
PHST- 2021/07/28 00:00 [pmc-release]
AID - 10.1155/2021/8842667 [doi]
PST - epublish
SO  - Case Rep Endocrinol. 2021 Jul 28;2021:8842667. doi: 10.1155/2021/8842667. 
      eCollection 2021.