PMID- 34368637 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240402 IS - 2572-4754 (Electronic) IS - 2572-4754 (Linking) VI - 4 DP - 2020 TI - Quantifying long-term health and economic outcomes for survivors of group B Streptococcus invasive disease in infancy: protocol of a multi-country study in Argentina, India, Kenya, Mozambique and South Africa. PG - 138 LID - 10.12688/gatesopenres.13185.2 [doi] LID - 138 AB - Sepsis and meningitis due to invasive group B Streptococcus (iGBS) disease during early infancy is a leading cause of child mortality. Recent systematic estimates of the worldwide burden of GBS suggested that there are 319,000 cases of infant iGBS disease each year, and an estimated 147,000 stillbirths and young-infant deaths, with the highest burden occurring in Sub-Saharan Africa. The following priority data gaps were highlighted: (1) long-term outcome data after infant iGBS, including mild disability, to calculate quality-adjusted life years (QALYs) or disability-adjusted life years (DALYs) and (2) economic burden for iGBS survivors and their families. Geographic data gaps were also noted with few studies from low- and middle- income countries (LMIC), where the GBS burden is estimated to be the highest. In this paper we present the protocol for a multi-country matched cohort study designed to estimate the risk of long-term neurodevelopmental impairment (NDI), socioemotional behaviors, and economic outcomes for children who survive invasive GBS disease in Argentina, India, Kenya, Mozambique, and South Africa. Children will be identified from health demographic surveillance systems, hospital records, and among participants of previous epidemiological studies. The children will be aged between 18 months to 17 years. A tablet-based custom-designed application will be used to capture data from direct assessment of the child and interviews with the main caregiver. In addition, a parallel sub-study will prospectively measure the acute costs of hospitalization due to neonatal sepsis or meningitis, irrespective of underlying etiology. In summary, these data are necessary to characterize the consequences of iGBS disease and enable the advancement of effective strategies for survivors to reach their developmental and economic potential. In particular, our study will inform the development of a full public health value proposition on maternal GBS immunization that is being coordinated by the World Health Organization. CI - Copyright: (c) 2021 Paul P et al. FAU - Paul, Proma AU - Paul P AD - Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, UK. AD - Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. FAU - Procter, Simon R AU - Procter SR AUID- ORCID: 0000-0002-0380-1503 AD - Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, UK. AD - Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. FAU - Dangor, Ziyaad AU - Dangor Z AD - Medical Research Council: Vaccines and Infectious Diseases Analytical Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Bassat, Quique AU - Bassat Q AD - ISGlobal, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain. AD - Centro de Investigacao em Saude de Manhica (CISM), Maputo, Mozambique. AD - ICREA, Barcelona, Spain. AD - Pediatric Infectious Diseases Unit, Pediatrics Department, Hospital Sant Joan de Deu (University of Barcelona), Barcelona, Spain. AD - Consorcio de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain. FAU - Abubakar, Amina AU - Abubakar A AD - Neuroscience Research Group, Department of Clinical Sciences, KEMRI-Wellcome Trust, Kilifi, Kenya. AD - Institute of Human Development, Aga Khan University, Nairobi, Kenya. FAU - Santhanam, Sridhar AU - Santhanam S AUID- ORCID: 0000-0002-5173-8481 AD - Neonatology Department, Christian Medical College, Vellore, India. FAU - Libster, Romina AU - Libster R AD - Fundacion INFANT, Buenos Aires, Argentina. AD - National Technical and Scientific Research Council, Buenos Aires, Argentina. FAU - Goncalves, Bronner P AU - Goncalves BP AUID- ORCID: 0000-0002-3329-6050 AD - Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, UK. AD - Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. FAU - Madhi, Shabir A AU - Madhi SA AD - Medical Research Council: Vaccines and Infectious Diseases Analytical Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. AD - Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Bardaji, Azucena AU - Bardaji A AD - ISGlobal, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain. AD - Centro de Investigacao em Saude de Manhica (CISM), Maputo, Mozambique. AD - Consorcio de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain. FAU - Mwangome, Eva AU - Mwangome E AUID- ORCID: 0000-0002-2783-6380 AD - Neuroscience Research Group, Department of Clinical Sciences, KEMRI-Wellcome Trust, Kilifi, Kenya. FAU - Mabrouk, Adam AU - Mabrouk A AD - Neuroscience Research Group, Department of Clinical Sciences, KEMRI-Wellcome Trust, Kilifi, Kenya. FAU - John, Hima B AU - John HB AD - Neonatology Department, Christian Medical College, Vellore, India. FAU - Sanchez Yanotti, Clara AU - Sanchez Yanotti C AD - Fundacion INFANT, Buenos Aires, Argentina. FAU - Chandna, Jaya AU - Chandna J AUID- ORCID: 0000-0001-9836-0554 AD - Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, UK. AD - Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. FAU - Sithole, Pamela AU - Sithole P AD - Medical Research Council: Vaccines and Infectious Diseases Analytical Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Mucasse, Humberto AU - Mucasse H AD - Centro de Investigacao em Saude de Manhica (CISM), Maputo, Mozambique. FAU - Katana, Patrick V AU - Katana PV AD - Neuroscience Research Group, Department of Clinical Sciences, KEMRI-Wellcome Trust, Kilifi, Kenya. FAU - Koukounari, Artemis AU - Koukounari A AD - Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, UK. AD - Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. FAU - Harden, Lois M AU - Harden LM AD - Brain Function Research Group, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Aerts, Celine AU - Aerts C AD - ISGlobal, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain. FAU - Ghoor, Azra AU - Ghoor A AD - Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Leahy, Shannon AU - Leahy S AD - Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Mbatha, Sibongile AU - Mbatha S AUID- ORCID: 0000-0002-2907-3145 AD - Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Lowick, Sarah AU - Lowick S AUID- ORCID: 0000-0001-9964-9448 AD - Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Lala, Sanjay G AU - Lala SG AD - Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Bramugy, Justina AU - Bramugy J AD - Centro de Investigacao em Saude de Manhica (CISM), Maputo, Mozambique. FAU - Newton, Charles AU - Newton C AD - Neuroscience Research Group, Department of Clinical Sciences, KEMRI-Wellcome Trust, Kilifi, Kenya. AD - Department of Psychiatry, Medical Sciences Division, University of Oxford, Oxford, UK. FAU - Hossain, A K M Tanvir AU - Hossain AKMT AD - Maternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh. FAU - Sadeq-Ur Rahman, Qazi AU - Sadeq-Ur Rahman Q AD - Maternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh. FAU - Lambach, Philipp AU - Lambach P AD - Department of Immunization, Vaccines and Biologicals (IVB), World Health Organization, Geneva, Switzerland. FAU - Jit, Mark AU - Jit M AD - Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. AD - Modelling and Economics Unit, Public Health England, London, UK. AD - Division of Epidemiology and Biostatistics, School of Public Health, University of Hong Kong, Hong Kong SAR, China. FAU - Lawn, Joy E AU - Lawn JE AD - Maternal, Adolescent, Reproductive & Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, UK. AD - Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. LA - eng GR - 001/WHO_/World Health Organization/International PT - Journal Article DEP - 20210719 PL - United States TA - Gates Open Res JT - Gates open research JID - 101717821 PMC - PMC8313848 OTO - NOTNLM OT - Group B streptococcus OT - children OT - cost OT - disability OT - economic OT - impairment OT - infants OT - meningitis OT - neurodevelopment OT - sepsis COIS- Competing interests: P. Lambach works for the World Health Organization (WHO). The authors alone are responsible for the views expressed in this publication and they do not necessarily represent the decisions, policy or views of the WHO. EDAT- 2021/08/11 06:00 MHDA- 2021/08/11 06:01 PMCR- 2021/07/19 CRDT- 2021/08/10 06:39 PHST- 2021/05/27 00:00 [accepted] PHST- 2021/08/10 06:39 [entrez] PHST- 2021/08/11 06:00 [pubmed] PHST- 2021/08/11 06:01 [medline] PHST- 2021/07/19 00:00 [pmc-release] AID - 10.12688/gatesopenres.13185.2 [doi] PST - epublish SO - Gates Open Res. 2021 Jul 19;4:138. doi: 10.12688/gatesopenres.13185.2. eCollection 2020.