PMID- 34370593
OWN - NLM
STAT- MEDLINE
DCOM- 20210921
LR  - 20240226
IS  - 1522-1555 (Electronic)
IS  - 0193-1849 (Linking)
VI  - 321
IP  - 3
DP  - 2021 Sep 1
TI  - Central GLP-1 contributes to improved cognitive function and brain glucose uptake 
      after duodenum-jejunum bypass on obese and diabetic rats.
PG  - E392-E409
LID - 10.1152/ajpendo.00126.2021 [doi]
AB  - The improvement of cognitive function following bariatric surgery has been 
      highlighted, yet its underlying mechanisms remain elusive. Finding the improved 
      brain glucose uptake of patients after Roux-en-Y gastric bypass (RYGB), 
      duodenum-jejunum bypass (DJB), and sham surgery (Sham) were performed on obese 
      and diabetic Wistar rats, and intracerebroventricular (ICV) injection of 
      glucagon-like peptide-1 (GLP-1) analog liraglutide (Lira), antagonist 
      exendin-(9-39) (Exe-9), and the viral-mediated GLP-1 receptor (Glp-1r) knockdown 
      (KD) were applied on both groups to elucidate the role of GLP-1 in mediating 
      cognitive function and brain glucose uptake assessed with the Morris water maze 
      (MWM) and positron emission tomography (PET). Insulin and GLP-1 in serum and 
      cerebral spinal fluid (CSF) were measured, and the expression of glucose 
      uptake-related proteins including glucose transporter 1 (GLUT-1), GLUT-4, 
      phospho-Akt substrate of 160kDa (pAS160), AS160, Rab10, Myosin-Va as well as the 
      c-fos marker in the brain were examined. Along with augmented glucose homeostasis 
      following DJB, central GLP-1 was correlated with the improved cognitive function 
      and ameliorated brain glucose uptake, which was further confirmed by the 
      enhancive role of Lira on both groups whereas the Exe-9 and Glp-1r KD were 
      opposite. Known to activate insulin-signaling pathways, central GLP-1 contributes 
      to improved cognitive function and brain glucose uptake after DJB.NEW & 
      NOTEWORTHY The improvement of cognitive function following bariatric surgery has 
      been highlighted while its mechanisms remain elusive. The brain glucose uptake of 
      patients was improved after RYGB, and the DJB and sham surgery performed on obese 
      and diabetic Wistar rats revealed that the elevated central GLP-1 contributes to 
      the dramatic improvement of cognitive function, brain glucose uptake, transport, 
      glucose sensing, and neuronal activation.
FAU - Ruze, Rexiati
AU  - Ruze R
AUID- ORCID: 0000-0002-0891-5307
AD  - Department of General Surgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College, Beijing, People's 
      Republic of China.
FAU - Xu, Qian
AU  - Xu Q
AD  - Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong 
      University, Jinan, People's Republic of China.
FAU - Liu, Guoqin
AU  - Liu G
AD  - Department of General Surgery, Jinan Central Hospital, Shandong University, 
      Jinan, People's Republic of China.
FAU - Li, Yuekai
AU  - Li Y
AD  - Department of Nuclear Medicine, Qilu Hospital, Cheeloo College of Medicine, 
      Shandong University, Jinan, People's Republic of China.
FAU - Chen, Weijie
AU  - Chen W
AD  - Department of General Surgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College, Beijing, People's 
      Republic of China.
FAU - Cheng, Zhiqiang
AU  - Cheng Z
AD  - Department of Colorectal Surgery, General Surgery, Qilu Hospital, Cheeloo College 
      of Medicine, Shandong University, Jinan, People's Republic of China.
FAU - Xiong, Yacheng
AU  - Xiong Y
AD  - Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong 
      University, Jinan, People's Republic of China.
FAU - Liu, Shaozhuang
AU  - Liu S
AD  - Department of Bariatric and Metabolic Surgery, General Surgery, Qilu Hospital, 
      Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of 
      China.
FAU - Zhang, Guangyong
AU  - Zhang G
AD  - Department of General Surgery, The First Affiliated Hospital of Shandong First 
      Medical University, Jinan, People's Republic of China.
FAU - Hu, Sanyuan
AU  - Hu S
AUID- ORCID: 0000-0002-0546-9778
AD  - Department of General Surgery, The First Affiliated Hospital of Shandong First 
      Medical University, Jinan, People's Republic of China.
FAU - Yan, Zhibo
AU  - Yan Z
AUID- ORCID: 0000-0003-3065-0621
AD  - Department of Colorectal Surgery, General Surgery, Qilu Hospital, Cheeloo College 
      of Medicine, Shandong University, Jinan, People's Republic of China.
AD  - Key Laboratory Experimental Teratology of the Ministry of Education and 
      Department of Physiology, School of Basic Medical Sciences, Cheeloo College of 
      Medicine, Shandong University, Jinan, People's Republic of China.
LA  - eng
SI  - figshare/10.6084/m9.figshare.14909709.v2
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210809
PL  - United States
TA  - Am J Physiol Endocrinol Metab
JT  - American journal of physiology. Endocrinology and metabolism
JID - 100901226
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Brain/metabolism
MH  - *Cognition
MH  - Diabetes Mellitus, Experimental/*metabolism
MH  - Duodenum/surgery
MH  - *Gastric Bypass
MH  - Glucagon-Like Peptide 1/*metabolism
MH  - Glucose
MH  - Jejunum/surgery
MH  - Obesity/*metabolism/surgery
MH  - Rats, Wistar
MH  - Rats
OTO - NOTNLM
OT  - brain glucose uptake
OT  - cerebral spinal fluid
OT  - duodenum-jejunum bypass
OT  - glucagon-like peptide-1
OT  - glucose transporter-1
EDAT- 2021/08/10 06:00
MHDA- 2021/09/22 06:00
CRDT- 2021/08/09 17:15
PHST- 2021/08/10 06:00 [pubmed]
PHST- 2021/09/22 06:00 [medline]
PHST- 2021/08/09 17:15 [entrez]
AID - 10.1152/ajpendo.00126.2021 [doi]
PST - ppublish
SO  - Am J Physiol Endocrinol Metab. 2021 Sep 1;321(3):E392-E409. doi: 
      10.1152/ajpendo.00126.2021. Epub 2021 Aug 9.