PMID- 34371009
OWN - NLM
STAT- MEDLINE
DCOM- 20220316
LR  - 20220316
IS  - 1095-6840 (Electronic)
IS  - 0016-6480 (Linking)
VI  - 313
DP  - 2021 Nov 1
TI  - Lipopolysaccharide inhibits hypothalamic Agouti-related protein gene expression 
      via activating mechanistic target of rapamycin signaling in chicks.
PG  - 113876
LID - S0016-6480(21)00169-6 [pii]
LID - 10.1016/j.ygcen.2021.113876 [doi]
AB  - Lipopolysaccharide (LPS) induces profound anorexia in birds. However, the 
      neuronal regulatory network underlying LPS-provoked anorexia is unclear. To 
      determine whether any cross talk occurs among hypothalamic mechanistic target of 
      rapamycin (mTOR) and LPS in the regulation of appetite, we performed an 
      intracerebroventricular injection of rapamycin (an mTOR inhibitor) on LPS-treated 
      chicks. The results indicate that peripheral administrations of LPS decreased the 
      agouti-related protein (AgRP) mRNA level, but increased the phosphorylated mTOR 
      and nuclear factor-small ka, CyrillicB (NF-small ka, CyrillicB) protein level. Blocking mTOR significantly 
      attenuated LPS-induced anorexia, AgRP suppression, and p-NF-small ka, CyrillicB increase. Thus, 
      the results suggest that LPS causes anorexia via the mTOR-AgRP signaling pathway, 
      and mTOR signaling is also associated with the regulation of LPS in p-NF-small ka, CyrillicB.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Wang, X J
AU  - Wang XJ
AD  - Department of Animal Science, Shandong Agricultural University, Shandong Key Lab 
      for Animal Biotechnology and Disease Control, Taian, Shandong 271018, China.
FAU - Li, D
AU  - Li D
AD  - Department of Animal Science, Shandong Agricultural University, Shandong Key Lab 
      for Animal Biotechnology and Disease Control, Taian, Shandong 271018, China.
FAU - Jiao, H C
AU  - Jiao HC
AD  - Department of Animal Science, Shandong Agricultural University, Shandong Key Lab 
      for Animal Biotechnology and Disease Control, Taian, Shandong 271018, China.
FAU - Zhao, J P
AU  - Zhao JP
AD  - Department of Animal Science, Shandong Agricultural University, Shandong Key Lab 
      for Animal Biotechnology and Disease Control, Taian, Shandong 271018, China.
FAU - Lin, H
AU  - Lin H
AD  - Department of Animal Science, Shandong Agricultural University, Shandong Key Lab 
      for Animal Biotechnology and Disease Control, Taian, Shandong 271018, China. 
      Electronic address: hailin@sdau.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210808
PL  - United States
TA  - Gen Comp Endocrinol
JT  - General and comparative endocrinology
JID - 0370735
RN  - 0 (Agouti-Related Protein)
RN  - 0 (Lipopolysaccharides)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Agouti-Related Protein/genetics
MH  - Gene Expression
MH  - *Lipopolysaccharides/toxicity
MH  - Signal Transduction
MH  - Sirolimus/pharmacology
MH  - *TOR Serine-Threonine Kinases
OTO - NOTNLM
OT  - AgRP
OT  - Appetite control
OT  - Chick
OT  - Lipopolysaccharide
OT  - mTOR
EDAT- 2021/08/10 06:00
MHDA- 2022/03/17 06:00
CRDT- 2021/08/09 20:09
PHST- 2021/06/10 00:00 [received]
PHST- 2021/07/25 00:00 [revised]
PHST- 2021/08/02 00:00 [accepted]
PHST- 2021/08/10 06:00 [pubmed]
PHST- 2022/03/17 06:00 [medline]
PHST- 2021/08/09 20:09 [entrez]
AID - S0016-6480(21)00169-6 [pii]
AID - 10.1016/j.ygcen.2021.113876 [doi]
PST - ppublish
SO  - Gen Comp Endocrinol. 2021 Nov 1;313:113876. doi: 10.1016/j.ygcen.2021.113876. 
      Epub 2021 Aug 8.