PMID- 34371090
OWN - NLM
STAT- MEDLINE
DCOM- 20211005
LR  - 20211005
IS  - 1096-0333 (Electronic)
IS  - 0041-008X (Linking)
VI  - 428
DP  - 2021 Oct 1
TI  - Effects of an environmentally relevant PFAS mixture on dopamine and steroid 
      hormone levels in exposed mice.
PG  - 115670
LID - S0041-008X(21)00274-X [pii]
LID - 10.1016/j.taap.2021.115670 [doi]
AB  - In the present study, we investigated the dopaminergic and steroid hormone 
      systems of A/J mice fed environmentally relevant concentrations of a 
      perfluoroalkyl substance (PFAS) mixture over a period of 10 weeks. The PFAS 
      mixture was chosen based on measured PFAS concentrations in earthworms at a 
      Norwegian skiing area (Trondheim) and consisted of eight different PFAS. Dietary 
      exposure to PFAS led to lower total brain dopamine (DA) concentrations in male 
      mice, as compared to control. On the transcript level, brain tyrosine hydroxylase 
      (th) of PFAS exposed males was reduced, compared to the control group. No 
      significant differences were observed on the transcript levels of enzymes 
      responsible for DA metabolism, namely - monoamine oxidase (maoa and maob) and 
      catechol-O methyltransferase (comt). We detected increased transcript level for 
      DA receptor 2 (dr2) in PFAS exposed females, while expression of DA receptor 1 
      (dr1), DA transporter (dat) and vesicular monoamine transporter (vmat) were not 
      affected by PFAS exposure. Regarding the steroid hormones, plasma and muscle 
      testosterone (T), 11-ketotestosterone (11-KT) and 17beta-estradiol (E2) levels, as 
      well as transcripts for estrogen receptors (esr1 and esr2), gonadotropin 
      releasing hormone (gnrh) and aromatase (cyp19) were unaltered by the PFAS 
      treatment. These results indicate that exposure to PFAS doses, comparable to 
      previous observation in earthworms at a Norwegian skiing area, may alter the 
      dopaminergic system of mice with overt consequences for health, general 
      physiology, cognitive behavior, reproduction and metabolism.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Gronnestad, Randi
AU  - Gronnestad R
AD  - Department of Biology, Norwegian University of Science and Technology, Trondheim, 
      Norway. Electronic address: randi.gronnestad@gmail.com.
FAU - Johanson, Silje Modahl
AU  - Johanson SM
AD  - Department of Production Animal Clinical Sciences, Norwegian University of Life 
      Sciences, Oslo, Norway.
FAU - Muller, Mette H B
AU  - Muller MHB
AD  - Department of Production Animal Clinical Sciences, Norwegian University of Life 
      Sciences, Oslo, Norway; Department of Paraclinical Sciences, Norwegian University 
      of Life Sciences, Oslo, Norway.
FAU - Schlenk, Daniel
AU  - Schlenk D
AD  - Department of Environmental Sciences, University of California, Riverside, 
      California, USA.
FAU - Tanabe, Philip
AU  - Tanabe P
AD  - Department of Environmental Sciences, University of California, Riverside, 
      California, USA.
FAU - Krokje, Ase
AU  - Krokje A
AD  - Department of Biology, Norwegian University of Science and Technology, Trondheim, 
      Norway.
FAU - Jaspers, Veerle L B
AU  - Jaspers VLB
AD  - Department of Biology, Norwegian University of Science and Technology, Trondheim, 
      Norway.
FAU - Jenssen, Bjorn Munro
AU  - Jenssen BM
AD  - Department of Biology, Norwegian University of Science and Technology, Trondheim, 
      Norway; Department of Biosciences, Aarhus University, Roskilde, Denmark.
FAU - Raeder, Erik M
AU  - Raeder EM
AD  - Department of Paraclinical Sciences, Norwegian University of Life Sciences, Oslo, 
      Norway.
FAU - Lyche, Jan L
AU  - Lyche JL
AD  - Department of Paraclinical Sciences, Norwegian University of Life Sciences, Oslo, 
      Norway.
FAU - Shi, Qingyang
AU  - Shi Q
AD  - Department of Environmental Sciences, University of California, Riverside, 
      California, USA.
FAU - Arukwe, Augustine
AU  - Arukwe A
AD  - Department of Biology, Norwegian University of Science and Technology, Trondheim, 
      Norway.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210808
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Fluorocarbons)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Receptors, Dopamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Dopamine/*metabolism
MH  - Environmental Exposure/*adverse effects
MH  - Female
MH  - Fluorocarbons/administration & dosage/*toxicity
MH  - Gonadal Steroid Hormones/*metabolism
MH  - Liver/drug effects/*metabolism/pathology
MH  - Male
MH  - Mice
MH  - Receptors, Dopamine/*metabolism
OTO - NOTNLM
OT  - Dopamine
OT  - PFAS mixture
OT  - Rodents
OT  - Ski products
OT  - Steroids
EDAT- 2021/08/10 06:00
MHDA- 2021/10/06 06:00
CRDT- 2021/08/09 20:11
PHST- 2021/04/24 00:00 [received]
PHST- 2021/07/30 00:00 [revised]
PHST- 2021/08/02 00:00 [accepted]
PHST- 2021/08/10 06:00 [pubmed]
PHST- 2021/10/06 06:00 [medline]
PHST- 2021/08/09 20:11 [entrez]
AID - S0041-008X(21)00274-X [pii]
AID - 10.1016/j.taap.2021.115670 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 2021 Oct 1;428:115670. doi: 10.1016/j.taap.2021.115670. 
      Epub 2021 Aug 8.