PMID- 34371890
OWN - NLM
STAT- MEDLINE
DCOM- 20210907
LR  - 20210907
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 13
IP  - 7
DP  - 2021 Jul 12
TI  - Glucose Fluctuation and Severe Internal Carotid Artery Siphon Stenosis in Type 2 
      Diabetes Patients.
LID - 10.3390/nu13072379 [doi]
LID - 2379
AB  - The impact of glucose fluctuation on intracranial artery stenosis remains to be 
      elucidated. This study aimed to investigate the association between glucose 
      fluctuation and intracranial artery stenosis. This was a cross-sectional study of 
      type 2 diabetes mellitus (T2DM) patients equipped with the FreeStyle Libre Pro 
      continuous glucose monitoring system (Abbott Laboratories) between February 2019 
      and June 2020. Glucose fluctuation was evaluated according to the standard 
      deviation (SD) of blood glucose, coefficient of variation (%CV), and mean 
      amplitude of glycemic excursions (MAGE). Magnetic resonance angiography was used 
      to evaluate the degree of intracranial artery stenosis. Of the 103 patients, 8 
      patients developed severe internal carotid artery (ICA) siphon stenosis (>/=70%). 
      SD, %CV, and MAGE were significantly higher in the severe stenosis group than in 
      the non-severe stenosis group (<70%), whereas there was no significant intergroup 
      difference in the mean blood glucose and HbA1c. Multivariable logistic regression 
      analysis adjusted for sex showed that SD, %CV, and MAGE were independent factors 
      associated with severe ICA siphon stenosis. In conclusion, glucose fluctuation is 
      significantly associated with severe ICA siphon stenosis in T2DM patients. Thus, 
      glucose fluctuation can be a target of preventive therapies for intracranial 
      artery stenosis and ischemic stroke.
FAU - Eto, Futoshi
AU  - Eto F
AUID- ORCID: 0000-0001-5030-1598
AD  - Department of Neurology, National Cerebral and Cardiovascular Center, Suita 
      564-8565, Japan.
FAU - Washida, Kazuo
AU  - Washida K
AD  - Department of Neurology, National Cerebral and Cardiovascular Center, Suita 
      564-8565, Japan.
FAU - Matsubara, Masaki
AU  - Matsubara M
AD  - Division of Diabetes and Lipid Metabolism, National Cerebral and Cardiovascular 
      Center, Suita 564-8565, Japan.
FAU - Makino, Hisashi
AU  - Makino H
AD  - Division of Diabetes and Lipid Metabolism, National Cerebral and Cardiovascular 
      Center, Suita 564-8565, Japan.
FAU - Takahashi, Akio
AU  - Takahashi A
AD  - Department of Neurology, National Cerebral and Cardiovascular Center, Suita 
      564-8565, Japan.
FAU - Noda, Kotaro
AU  - Noda K
AUID- ORCID: 0000-0003-2690-4318
AD  - Department of Neurology, National Cerebral and Cardiovascular Center, Suita 
      564-8565, Japan.
FAU - Hattori, Yorito
AU  - Hattori Y
AD  - Department of Neurology, National Cerebral and Cardiovascular Center, Suita 
      564-8565, Japan.
FAU - Nakaoku, Yuriko
AU  - Nakaoku Y
AUID- ORCID: 0000-0002-3100-574X
AD  - Department of Preventive Medicine and Epidemiology, National Cerebral and 
      Cardiovascular Center, Suita 564-8565, Japan.
FAU - Nishimura, Kunihiro
AU  - Nishimura K
AUID- ORCID: 0000-0002-0639-0949
AD  - Department of Preventive Medicine and Epidemiology, National Cerebral and 
      Cardiovascular Center, Suita 564-8565, Japan.
FAU - Hosoda, Kiminori
AU  - Hosoda K
AD  - Division of Diabetes and Lipid Metabolism, National Cerebral and Cardiovascular 
      Center, Suita 564-8565, Japan.
FAU - Ihara, Masafumi
AU  - Ihara M
AUID- ORCID: 0000-0002-7102-4048
AD  - Department of Neurology, National Cerebral and Cardiovascular Center, Suita 
      564-8565, Japan.
LA  - eng
GR  - 18ek0210104h0001/Japan Agency for Medical Research and Development/
PT  - Journal Article
PT  - Observational Study
DEP - 20210712
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Aged
MH  - Blood Glucose/*metabolism
MH  - Blood Glucose Self-Monitoring
MH  - Carotid Artery, Internal/*pathology
MH  - Carotid Stenosis/*complications/*diagnosis
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Female
MH  - Humans
MH  - Intracranial Arterial Diseases/*complications/*diagnosis
MH  - Magnetic Resonance Angiography
MH  - Male
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC8308661
OTO - NOTNLM
OT  - continuous glucose monitoring
OT  - glucose fluctuation
OT  - intracranial artery stenosis
OT  - mean amplitude of glycemic excursions
OT  - standard deviation
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/11 06:00
MHDA- 2021/09/08 06:00
PMCR- 2021/07/12
CRDT- 2021/08/10 01:02
PHST- 2021/06/18 00:00 [received]
PHST- 2021/07/08 00:00 [revised]
PHST- 2021/07/10 00:00 [accepted]
PHST- 2021/08/10 01:02 [entrez]
PHST- 2021/08/11 06:00 [pubmed]
PHST- 2021/09/08 06:00 [medline]
PHST- 2021/07/12 00:00 [pmc-release]
AID - nu13072379 [pii]
AID - nutrients-13-02379 [pii]
AID - 10.3390/nu13072379 [doi]
PST - epublish
SO  - Nutrients. 2021 Jul 12;13(7):2379. doi: 10.3390/nu13072379.