PMID- 34371968
OWN - NLM
STAT- MEDLINE
DCOM- 20210903
LR  - 20210903
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 13
IP  - 7
DP  - 2021 Jul 19
TI  - The Emerging Role of Sfrp5 and Wnt5a in the Pathogenesis of Obesity: Implications 
      for a Healthy Diet and Lifestyle.
LID - 10.3390/nu13072459 [doi]
LID - 2459
AB  - In recent decades, the prevalence of obesity has risen dramatically worldwide 
      among all age groups. Obesity is characterized by excess fat accumulation and 
      chronic low-grade inflammation. The adipose tissue functions as a metabolically 
      active endocrine organ secreting adipokines. A novel duo of adipokines, the 
      anti-inflammatory secreted frizzled-related protein 5 (Sfrp5) and the 
      proinflammatory wingless type mouse mammary tumor virus (MMTV) integration site 
      family member 5A (Wnt5a), signal via the non-canonical Wnt pathway. Recent 
      evidence suggests that Sfpr5 and Wnt5a play a key role in the pathogenesis of 
      obesity and its metabolic complications. This review summarizes the current 
      knowledge on the novel regulatory system of anti-inflammatory Sfrp5 and 
      pro-inflammatory Wnt5a, and their relation to obesity and obesity-related 
      complications. Future studies are required to investigate the potential role of 
      Sfrp5 and Wnt5a as biomarkers for monitoring the response to lifestyle 
      interventions and for predicting the development of cardiometabolic risk factors. 
      These adipokines may also serve as novel therapeutic targets for obesity-related 
      disorders.
FAU - Koutaki, Diamanto
AU  - Koutaki D
AD  - Division of Endocrinology, Metabolism and Diabetes, First Department of 
      Pediatrics, National and Kapodistrian University of Athens Medical School, "Aghia 
      Sophia" Children's Hospital, 11527 Athens, Greece.
FAU - Michos, Athanasios
AU  - Michos A
AUID- ORCID: 0000-0003-1745-1118
AD  - Division of Infectious Diseases, First Department of Pediatrics, National and 
      Kapodistrian University of Athens Medical School, "Aghia Sophia" Children's 
      Hospital, 11527 Athens, Greece.
FAU - Bacopoulou, Flora
AU  - Bacopoulou F
AUID- ORCID: 0000-0003-1001-0926
AD  - University Research Institute of Maternal and Child Health & Precision Medicine, 
      and UNESCO Chair on Adolescent Health Care, National and Kapodistrian University 
      of Athens, "Aghia Sophia" Children's Hospital, 11527 Athens, Greece.
FAU - Charmandari, Evangelia
AU  - Charmandari E
AUID- ORCID: 0000-0002-0851-6998
AD  - Division of Endocrinology, Metabolism and Diabetes, First Department of 
      Pediatrics, National and Kapodistrian University of Athens Medical School, "Aghia 
      Sophia" Children's Hospital, 11527 Athens, Greece.
AD  - Division of Endocrinology and Metabolism, Center of Clinical, Experimental 
      Surgery and Translational Research, Biomedical Research Foundation of the Academy 
      of Athens, 11527 Athens, Greece.
LA  - eng
GR  - (project code: T1EDK-01386, MIS: 5030543, Acronym: PEDOBESITY)./This research has 
      been co-financed by the European Regional Development Fund of the European Union 
      and Greek national funds through the Operational Program Competitiveness, 
      Entrepreneurship and Innovation, under the call RESEARCH - CREATE - INNOVATE/
PT  - Journal Article
PT  - Review
DEP - 20210719
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (SFRP5 protein, human)
RN  - 0 (WNT5A protein, human)
RN  - 0 (Wnt-5a Protein)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/*physiology
MH  - Adipose Tissue/physiopathology
MH  - Adolescent
MH  - Adult
MH  - Animals
MH  - Cardiometabolic Risk Factors
MH  - Child
MH  - Diet, Healthy
MH  - Humans
MH  - Inflammation/physiopathology
MH  - Insulin Resistance
MH  - Life Style
MH  - Non-alcoholic Fatty Liver Disease
MH  - Obesity/*etiology/physiopathology/therapy
MH  - Wnt-5a Protein/*physiology
PMC - PMC8308727
OTO - NOTNLM
OT  - SFRP5
OT  - Wnt5a
OT  - childhood
OT  - metabolic
OT  - obesity
OT  - overweight
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/11 06:00
MHDA- 2021/09/04 06:00
PMCR- 2021/07/19
CRDT- 2021/08/10 01:03
PHST- 2021/05/06 00:00 [received]
PHST- 2021/07/05 00:00 [revised]
PHST- 2021/07/09 00:00 [accepted]
PHST- 2021/08/10 01:03 [entrez]
PHST- 2021/08/11 06:00 [pubmed]
PHST- 2021/09/04 06:00 [medline]
PHST- 2021/07/19 00:00 [pmc-release]
AID - nu13072459 [pii]
AID - nutrients-13-02459 [pii]
AID - 10.3390/nu13072459 [doi]
PST - epublish
SO  - Nutrients. 2021 Jul 19;13(7):2459. doi: 10.3390/nu13072459.