PMID- 34373946
OWN - NLM
STAT- MEDLINE
DCOM- 20220406
LR  - 20220406
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 37
IP  - 2
DP  - 2022 Feb
TI  - Acute myocarditis with autoimmune features: one-year follow-up with CMR.
PG  - 291-299
LID - 10.1007/s00380-021-01917-9 [doi]
AB  - In this prospective study on patients with acute myocarditis (AM), we aimed to 
      describe the new concept of AMAF (AM with autoimmune features) similar to the 
      previously described interstitial pneumonia with autoimmune features (IPAF). IPAF 
      has recently emerged as a new entity, and IPAF patients appear to have fewer 
      episodes of exacerbation and better survival than patients with idiopathic 
      pulmonary fibrosis. Consecutive patients with infarct-like CMR-confirmed AM were 
      classified AMAF if their serologic status measured from blood sampled at 
      presentation was positive (antinuclear antibodies (ANA) >/= 1:320), but without 
      meeting established classification criteria for connective tissue disease (CTD). 
      The myocardial tissue abnormalities and their progression were assessed on 
      cardiac magnetic resonance (CMR) within 7 days following symptom onset and at 
      1 year according to their seropositivity. Among the 64 AM patients included, 
      seven presented AMAF (11%). At baseline CMR, patients with AMAF had half as much 
      late gadolinium enhancement (LGE) as seronegative AM patients (4.41% (1.47-4.41) 
      of myocardial volume versus 8.82% (5.88-14.71), p = 0.01, respectively). At 
      1-year of follow-up, persistent myocardial scarring was less frequent in AMAF 
      patients (n = 2 (28.6%) than seronegative AM patients (n = 38 (66.7%) 
      (p = 0.021). AMAF, diagnosed as seropositive AM without a specific autoimmune 
      disease, is not rare and is associated with less extensive LGE in the acute 
      phase. In addition, AMAF patients had more favorable outcomes on 12-month CMR. 
      Prospective studies are needed to address the clinical significance of this new 
      concept and its long-term cardiovascular impact.
CI  - (c) 2021. Springer Japan KK, part of Springer Nature.
FAU - Lairet, Celine
AU  - Lairet C
AD  - Department of Cardiology, Dijon-Bourgogne University Hospital, 14 rue Gaffarel, 
      21079, Dijon Cedex, France.
FAU - Greigert, Helene
AU  - Greigert H
AD  - Department of Internal Medicine, Dijon-Bourgogne University Hospital, 14 rue 
      Gaffarel, 21079, Dijon Cedex, France.
FAU - Pommier, Thibaut
AU  - Pommier T
AD  - Department of Cardiology, Dijon-Bourgogne University Hospital, 14 rue Gaffarel, 
      21079, Dijon Cedex, France.
FAU - Leclercq, Thibault
AU  - Leclercq T
AD  - Department of Cardiology, Dijon-Bourgogne University Hospital, 14 rue Gaffarel, 
      21079, Dijon Cedex, France.
AD  - Department of Imagery, Dijon-Bourgogne University Hospital, 14 rue Gaffarel, 
      21079, Dijon Cedex, France.
FAU - Maza, Maud
AU  - Maza M
AD  - Department of Cardiology, Dijon-Bourgogne University Hospital, 14 rue Gaffarel, 
      21079, Dijon Cedex, France.
FAU - Artus, Adrien
AU  - Artus A
AD  - Department of Cardiology, Dijon-Bourgogne University Hospital, 14 rue Gaffarel, 
      21079, Dijon Cedex, France.
FAU - Genet, Thibaud
AU  - Genet T
AD  - Department of Cardiology, University Teaching Hospital of Trousseau and EA7505, 
      University Francois Rabelais, 37000, Tours, France.
FAU - Samson, Maxime
AU  - Samson M
AD  - Department of Internal Medicine, Dijon-Bourgogne University Hospital, 14 rue 
      Gaffarel, 21079, Dijon Cedex, France.
FAU - Fauchier, Laurent
AU  - Fauchier L
AD  - Department of Cardiology, University Teaching Hospital of Trousseau and EA7505, 
      University Francois Rabelais, 37000, Tours, France.
FAU - Zeller, Marianne
AU  - Zeller M
AD  - PEC2 Research Team, EA 7460, Department of Health Sciences, University of 
      Burgundy, 21079, Dijon Cedex, France.
FAU - Cochet, Alexandre
AU  - Cochet A
AD  - Department of Imagery, Dijon-Bourgogne University Hospital, 14 rue Gaffarel, 
      21079, Dijon Cedex, France.
FAU - Bonnotte, Bernard
AU  - Bonnotte B
AD  - Department of Internal Medicine, Dijon-Bourgogne University Hospital, 14 rue 
      Gaffarel, 21079, Dijon Cedex, France.
FAU - Cottin, Yves
AU  - Cottin Y
AUID- ORCID: 0000-0002-5176-5121
AD  - Department of Cardiology, Dijon-Bourgogne University Hospital, 14 rue Gaffarel, 
      21079, Dijon Cedex, France. yves.cottin@chu-dijon.fr.
LA  - eng
PT  - Journal Article
DEP - 20210809
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Contrast Media
MH  - Follow-Up Studies
MH  - Gadolinium
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine
MH  - Magnetic Resonance Spectroscopy
MH  - *Myocarditis/diagnostic imaging
MH  - Myocardium/pathology
MH  - Prospective Studies
OTO - NOTNLM
OT  - Acute myocarditis
OT  - Antinuclear antibodies
OT  - Cardiac magnetic resonance
OT  - One-year follow-up
EDAT- 2021/08/11 06:00
MHDA- 2022/04/07 06:00
CRDT- 2021/08/10 06:44
PHST- 2021/04/13 00:00 [received]
PHST- 2021/07/28 00:00 [accepted]
PHST- 2021/08/11 06:00 [pubmed]
PHST- 2022/04/07 06:00 [medline]
PHST- 2021/08/10 06:44 [entrez]
AID - 10.1007/s00380-021-01917-9 [pii]
AID - 10.1007/s00380-021-01917-9 [doi]
PST - ppublish
SO  - Heart Vessels. 2022 Feb;37(2):291-299. doi: 10.1007/s00380-021-01917-9. Epub 2021 
      Aug 9.