PMID- 34374401
OWN - NLM
STAT- MEDLINE
DCOM- 20220214
LR  - 20240109
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 12
IP  - 18
DP  - 2021 Sep 20
TI  - Sargassum fusiforme fucoidan alleviates diet-induced insulin resistance by 
      inhibiting colon-derived ceramide biosynthesis.
PG  - 8440-8453
LID - 10.1039/d1fo01272j [doi]
AB  - Sargassum fusiforme fucoidan (SFF) is a highly sulfated heteropolysaccharide with 
      various biological activities. As one of the causative factors of type 2 diabetes 
      mellitus (T2DM), insulin resistance has become a global health issue. In this 
      study, we investigated the potential pharmacological mechanisms by which SFF 
      ameliorates insulin resistance in high-fat diet (HFD)-fed mice. SFF significantly 
      enhanced tauroursodeoxycholic acid (TUDCA, a conjugated bile acid) levels and 
      inhibited the farnesoid X receptor (FXR) signaling in the colon. SFF 
      administration reduced ceramide levels in both serum and colonic tissue of 
      HFD-fed mice, as well as reduced expression of SPT and CerS genes, which encode 
      enzymes crucial to the biosynthesis of ceramides regulated by FXR signaling. 
      Pearson's analysis showed that the TUDCA level was positively correlated with the 
      gut bacteria Clostridium, and this was further validated in pseudo-germfree mice. 
      Taken together, the results suggested that SFF increased TUDCA levels by 
      remodeling gut microbiota, and TUDCA, a natural FXR antagonist, inhibited the 
      FXR/SHP signaling pathway to reduce colon-derived biosynthesis of ceramide, 
      thereby improving insulin resistance in the diet-induced obese (DIO) mice. This 
      study has provided new insights into the therapeutic potential of S. fusiforme 
      fucoidan in metabolic diseases.
FAU - Zhang, Ya
AU  - Zhang Y
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China. tonghaibin@gmail.com.
AD  - Environmental Science and Environmental Engineering, University of Northern 
      British Columbia, Prince George, BC, Canada.
FAU - Liu, Jian
AU  - Liu J
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China. tonghaibin@gmail.com.
FAU - Mao, Genxiang
AU  - Mao G
AUID- ORCID: 0000-0001-7061-4479
AD  - Zhejiang Provincial Key Lab of Geriatrics, Department of Geriatrics, Zhejiang 
      Hospital, Hangzhou 310013, China.
FAU - Zuo, Jihui
AU  - Zuo J
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China. tonghaibin@gmail.com.
FAU - Li, Shijun
AU  - Li S
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China. tonghaibin@gmail.com.
FAU - Yang, Yue
AU  - Yang Y
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China. tonghaibin@gmail.com.
FAU - Thring, Ronald W
AU  - Thring RW
AD  - Environmental Science and Environmental Engineering, University of Northern 
      British Columbia, Prince George, BC, Canada.
FAU - Wu, Mingjiang
AU  - Wu M
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China. tonghaibin@gmail.com.
FAU - Tong, Haibin
AU  - Tong H
AUID- ORCID: 0000-0002-7645-3458
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China. tonghaibin@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20210920
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Ceramides)
RN  - 0 (Polysaccharides)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0C5V0MRU6P (farnesoid X-activated receptor)
RN  - 516-35-8 (Taurochenodeoxycholic Acid)
RN  - 60EUX8MN5X (ursodoxicoltaurine)
RN  - 9072-19-9 (fucoidan)
SB  - IM
MH  - Animals
MH  - Caco-2 Cells
MH  - Ceramides/*biosynthesis
MH  - Colonic Neoplasms
MH  - Diet, High-Fat/*adverse effects
MH  - Gastrointestinal Microbiome
MH  - Humans
MH  - *Insulin Resistance
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Obesity/chemically induced
MH  - Polysaccharides/chemistry/*pharmacology
MH  - Receptors, Cytoplasmic and Nuclear
MH  - Sargassum/*chemistry
MH  - Taurochenodeoxycholic Acid/pharmacology
EDAT- 2021/08/11 06:00
MHDA- 2022/02/15 06:00
CRDT- 2021/08/10 09:20
PHST- 2021/08/11 06:00 [pubmed]
PHST- 2022/02/15 06:00 [medline]
PHST- 2021/08/10 09:20 [entrez]
AID - 10.1039/d1fo01272j [doi]
PST - epublish
SO  - Food Funct. 2021 Sep 20;12(18):8440-8453. doi: 10.1039/d1fo01272j.