PMID- 34374501
OWN - NLM
STAT- MEDLINE
DCOM- 20211125
LR  - 20230821
IS  - 1538-943X (Electronic)
IS  - 1058-2916 (Linking)
VI  - 67
IP  - 10
DP  - 2021 Oct 1
TI  - Risk Factors of Venoarterial Extracorporeal Membrane Oxygenation-Related 
      Intracranial Hemorrhage in Children with Congenital Heart Disease.
PG  - 1170-1175
LID - 10.1097/MAT.0000000000001339 [doi]
AB  - To analyze the risk factors for intracranial hemorrhage (ICH) in congenital heart 
      disease (CHD) patients supported with venoarterial extracorporeal membrane 
      oxygenation (VA-ECMO). We performed a retrospective analysis of VA ECMO patients 
      after open heart surgery in Shanghai Children's Medical Center from February 2017 
      to December 2018, with a total of 50 patients: 14 patients in the ICH group and 
      36 patients in the control group. Clinical data were analyzed and compared 
      between groups to search for risk factors for ICH. The overall incidence of ICH 
      was 28% (14/50). The in-hospital mortality rate of the ICH group was 57.1% (8/14) 
      vs. 58.3% (21/36) in the control group. The proportion of neonates in the ICH 
      group was 64.3% (9/14) vs. 25% in the control group (9/36) (p = 0.009), and the 
      ICH incidence in extracorporeal cardiopulmonary resuscitation (ECPR) patients was 
      64.3% (9/14) vs. 13.9% (5/36) (p = 0.000). The percentage of selective cerebral 
      perfusion in the ICH group was 64.3% (9/14) vs. 16.7% (6/36) (p = 0.001) in the 
      control group, and the maximum procalcitonin (PCT) was 43.70 +/- 30.48 ng/ml in the 
      ICH group versus 26.92 +/- 23.28 ng/ml (p = 0.050) in the control group. 
      Multivariate analysis showed that neonates (odds ratio [OR] = 6.47 [1.09-38.46]), 
      ECPR use (OR = 7.48 [1.26-44.41]), and maximum PCT values (OR = 1.04 
      [1.001-1.070]) were independent risk factors for ICH. The probability of ICH 
      remains high in children supported with VA-ECMO after cardiac surgery. Neonatal 
      patients, ECPR use, and PCT peak values are independent risk factors for ICH.
CI  - Copyright (c) ASAIO 2021.
FAU - Yang, Yinyu
AU  - Yang Y
AD  - From the Department of Pediatric Thoracic and Cardiovascular Surgery, Shanghai 
      Children's Medical Center, Shanghai, China.
FAU - Yu, Xindi
AU  - Yu X
FAU - Guo, Zheng
AU  - Guo Z
FAU - Zhang, Wei
AU  - Zhang W
FAU - Shen, Jia
AU  - Shen J
FAU - Wang, Wei
AU  - Wang W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
SB  - IM
MH  - Child
MH  - China
MH  - *Extracorporeal Membrane Oxygenation/adverse effects
MH  - *Heart Defects, Congenital/complications
MH  - Humans
MH  - Infant, Newborn
MH  - Intracranial Hemorrhages/epidemiology/etiology
MH  - Retrospective Studies
MH  - Risk Factors
COIS- Disclosure: The authors have no conflicts of interest to report.
EDAT- 2021/08/11 06:00
MHDA- 2021/11/26 06:00
CRDT- 2021/08/10 11:45
PHST- 2021/08/11 06:00 [pubmed]
PHST- 2021/11/26 06:00 [medline]
PHST- 2021/08/10 11:45 [entrez]
AID - 00002480-202110000-00015 [pii]
AID - 10.1097/MAT.0000000000001339 [doi]
PST - ppublish
SO  - ASAIO J. 2021 Oct 1;67(10):1170-1175. doi: 10.1097/MAT.0000000000001339.