PMID- 34374805
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20211015
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 238
IP  - 10
DP  - 2021 Oct
TI  - Human umbilical cord mesenchymal stem cells ameliorate depression by regulating 
      Jmjd3 and microglia polarization in myocardial infarction mice.
PG  - 2973-2984
LID - 10.1007/s00213-021-05912-w [doi]
AB  - RATIONALE: Microglia regulate the inflammation of the central nervous system and 
      play a crucial role in the pathogenesis of depression. Moreover, Jmjd3 is 
      involved in microglia polarization. Mounting studies reported the beneficial 
      effects of human umbilical cord mesenchymal stem cells (HUC-MSCs) on myocardial 
      infarction (MI), Unfortunately, its effects on MI-induced depression and its 
      underlying mechanisms remain unclear. OBJECTIVES: We aimed to investigate the 
      antidepressant effects of HUC-MSCs and their impacts on microglia polarization. 
      METHODS: In the current study, the MI model was established by ligating the left 
      anterior descending coronary artery. Mice were injected with HUC-MSCs or PBS 
      through the tail vein 1week after the surgery. The sucrose preference test (SPT), 
      tail suspension test (TST), and forced swim test (FST) were performed to evaluate 
      depression-like behavior. Cardiac function and myocardial fibrosis were evaluated 
      at the end of the experiments. Immunofluorescence, Western blot, ELISA, and 
      qRT-PCR were used to detect the levels of Jmjd3 and microglia-related markers and 
      inflammatory factors. RESULTS: HUC-MSC treatment significantly improved cardiac 
      function, reduced the area of myocardial fibrosis, and alleviated depression-like 
      behaviors induced by MI. HUC-MSCs inhibited the expression of Jmjd3 and promoted 
      the switch of microglia in the prefrontal cortex, hypothalamus, and hippocampus 
      from M1 to M2, thereby decreased the level of pro-inflammatory factors. 
      CONCLUSION: HUC-MSCs have cardioprotective and potential anti-depressive effects 
      induced by MI related to the inflammation improved by regulating Jmjd3 and 
      microglial polarization.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Zhang, Youyang
AU  - Zhang Y
AD  - Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, 
      Shanghai, 200092, China.
AD  - Department of Geriatrics, Tongji Hospital, School of Medicine, Tongji University, 
      Shanghai, 200092, China.
FAU - Wang, Xinan
AU  - Wang X
AD  - Department of Urology, Tongji Hospital, School of Medicine, Tongji University, 
      389 Xincun Rd, Putuo District, Shanghai, 200092, China.
FAU - Li, Yuhang
AU  - Li Y
AD  - Department of Geriatrics, Tongji Hospital, School of Medicine, Tongji University, 
      Shanghai, 200092, China.
FAU - Liu, Ruiping
AU  - Liu R
AD  - Department of Geriatrics, Tongji Hospital, School of Medicine, Tongji University, 
      Shanghai, 200092, China.
FAU - Pan, Jiangqi
AU  - Pan J
AD  - Department of Cardiology, Gongli Hospital, Navy Military Medical University, 
      Shanghai, China.
FAU - Tang, Xiane
AU  - Tang X
AD  - Department of Clinical Medicine, School of Medicine, Hubei University for 
      Nationalities, Enshi, China.
FAU - Sun, Shuifen
AU  - Sun S
AD  - Regenerative Medicine Research Center, The First People's Hospital of Yunnan 
      Province, The Affiliated Hospital of Kunming University of Science and 
      Technology, Kunming, Yunnan, China.
FAU - Liu, Jie
AU  - Liu J
AD  - Regenerative Medicine Research Center, The First People's Hospital of Yunnan 
      Province, The Affiliated Hospital of Kunming University of Science and 
      Technology, Kunming, Yunnan, China.
FAU - Ma, Wenlin
AU  - Ma W
AUID- ORCID: 0000-0002-1591-7028
AD  - Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, 
      Shanghai, 200092, China. mawenlin@tongji.edu.cn.
AD  - Department of Geriatrics, Tongji Hospital, School of Medicine, Tongji University, 
      Shanghai, 200092, China. mawenlin@tongji.edu.cn.
LA  - eng
GR  - 2018YFC1314700/National Key R&D Program of China/
GR  - 2019ZB0202/Shanghai Municipal Health Commission Foundation of Shanghai/
GR  - 2019SY026/Shanghai Municipal Health Commission Foundation of Shanghai/
GR  - ITJ[ZD]1809/SShanghai Tongji Hospital/
GR  - 82060242/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20210810
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
SB  - IM
MH  - Animals
MH  - Depression
MH  - Humans
MH  - *Mesenchymal Stem Cell Transplantation
MH  - *Mesenchymal Stem Cells
MH  - Mice
MH  - Microglia
MH  - *Myocardial Infarction/therapy
MH  - Umbilical Cord
OTO - NOTNLM
OT  - Depression
OT  - HUC-MSCs
OT  - Inflammation
OT  - Jmjd3
OT  - Microglia
OT  - Myocardial infarction
EDAT- 2021/08/11 06:00
MHDA- 2021/10/16 06:00
CRDT- 2021/08/10 12:31
PHST- 2021/02/04 00:00 [received]
PHST- 2021/06/24 00:00 [accepted]
PHST- 2021/08/11 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2021/08/10 12:31 [entrez]
AID - 10.1007/s00213-021-05912-w [pii]
AID - 10.1007/s00213-021-05912-w [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2021 Oct;238(10):2973-2984. doi: 
      10.1007/s00213-021-05912-w. Epub 2021 Aug 10.