PMID- 34375304
OWN - NLM
STAT- MEDLINE
DCOM- 20220119
LR  - 20220119
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 13
IP  - 16
DP  - 2021 Aug 10
TI  - Long non-coding RNA ABHD11-AS1 promotes colorectal cancer progression and 
      invasion through targeting the integrin subunit alpha 5/focal adhesion 
      kinase/phosphoinositide 3 kinase/Akt signaling pathway.
PG  - 20179-20191
LID - 10.18632/aging.203342 [doi]
AB  - Long non-coding (lnc)RNA ABHD11-AS1 participates in the development and progress 
      of various cancers, but its role in colorectal cancer (CRC) remains poorly known. 
      In the present study, public database analysis and quantitative reverse 
      transcription PCR of CRC and normal tissues showed that ABHD11-AS1 was 
      overexpressed in CRC and associated with poor prognosis in CRC patients. Both in 
      vitro and in vivo experiments demonstrated that loss-of-function of ABHD11-AS1 
      attenuated the proliferation, migration, and invasion of CRC cells and induced 
      their apoptosis. Transcriptome sequencing and Kyoto Encyclopedia of Genes and 
      Genomes pathway enrichment analysis indicated that the phosphoinositide 3 kinase 
      (PI3K)/Akt signaling pathway is a potential target of ABHD11-AS1. Additionally, 
      we noted that ABHD11-AS1 deficiency reduced integrin subunit alpha (ITGA)5 
      expression, and impaired the phosphorylation of P85, focal adhesion kinase (FAK), 
      and Akt1 in CRC cell lines and tumor tissues of nude mice. Furthermore, we 
      observed that ITGA5 overexpression abrogated the effect of ABHD11-AS1 knockdown 
      on the proliferation and invasion abilities of CRC cells. Taken together, our 
      studies suggest that lncRNA ABHD11-AS1 promotes proliferation, migration, and 
      invasion in CRC by activating the ITGA5/Fak/PI3K/Akt signaling pathway, and that 
      the ITGA5/Fak/PI3K/Akt axis is a promising target for CRC therapy.
FAU - Luo, Jia
AU  - Luo J
AD  - Department of Gastroenterology, Affiliated Sanming First Hospital of Fujian 
      Medical University, Sanming 365000, Fujian, China.
FAU - Jiang, Yigui
AU  - Jiang Y
AD  - Department of Gastroenterology, Affiliated Sanming First Hospital of Fujian 
      Medical University, Sanming 365000, Fujian, China.
FAU - Wu, Lianhui
AU  - Wu L
AD  - Department of Endoscope Room, Affiliated Sanming First Hospital of Fujian Medical 
      University, Sanming 365000, Fujian, China.
FAU - Zhuo, Dexiang
AU  - Zhuo D
AD  - Department of Clinical Laboratory, Affiliated Sanming First Hospital of Fujian 
      Medical University, Sanming 365000, Fujian, China.
FAU - Zhang, Shengjun
AU  - Zhang S
AD  - Department of Gastroenterology, Affiliated Sanming First Hospital of Fujian 
      Medical University, Sanming 365000, Fujian, China.
FAU - Jiang, Xiang
AU  - Jiang X
AD  - Department of Gynecology, Affiliated Sanming First Hospital of Fujian Medical 
      University, Sanming 365000, Fujian, China.
FAU - Sun, Yingming
AU  - Sun Y
AD  - Department of Medical and Radiation Oncology, Affiliated Sanming First Hospital 
      of Fujian Medical University, Sanming 365000, Fujian, China.
FAU - Huang, Yue
AU  - Huang Y
AD  - Department of Gastroenterology, Affiliated Sanming First Hospital of Fujian 
      Medical University, Sanming 365000, Fujian, China.
AD  - Department of Endoscope Room, Affiliated Sanming First Hospital of Fujian Medical 
      University, Sanming 365000, Fujian, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210810
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - 0 (ITGA5 protein, human)
RN  - 0 (Integrins)
RN  - 0 (RNA, Antisense)
RN  - 0 (RNA, Long Noncoding)
RN  - EC 2.7.1.137 (Phosphatidylinositol 3-Kinase)
RN  - EC 2.7.10.2 (Focal Adhesion Protein-Tyrosine Kinases)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 3.4.- (ABHD11 protein, human)
RN  - EC 3.4.- (Serine Proteases)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Cell Line, Tumor
MH  - Colorectal Neoplasms/genetics/*metabolism/pathology/physiopathology
MH  - Disease Progression
MH  - Focal Adhesion Protein-Tyrosine Kinases/genetics/*metabolism
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Integrins/genetics/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neoplasm Invasiveness
MH  - Phosphatidylinositol 3-Kinase/genetics/*metabolism
MH  - Proto-Oncogene Proteins c-akt/genetics/*metabolism
MH  - RNA, Antisense/genetics/metabolism
MH  - RNA, Long Noncoding/genetics/*metabolism
MH  - Serine Proteases/genetics/*metabolism
MH  - Signal Transduction
PMC - PMC8436895
OTO - NOTNLM
OT  - PI3K/Akt pathway
OT  - colorectal cancer
OT  - lncRNA-ABHD11-AS1
OT  - oncogene profile
COIS- CONFLICTS OF INTEREST: The authors declare that they have no conflicts of 
      interest.
EDAT- 2021/08/11 06:00
MHDA- 2022/01/20 06:00
PMCR- 2021/08/31
CRDT- 2021/08/10 17:14
PHST- 2020/09/19 00:00 [received]
PHST- 2021/07/06 00:00 [accepted]
PHST- 2021/08/11 06:00 [pubmed]
PHST- 2022/01/20 06:00 [medline]
PHST- 2021/08/10 17:14 [entrez]
PHST- 2021/08/31 00:00 [pmc-release]
AID - 203342 [pii]
AID - 10.18632/aging.203342 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2021 Aug 10;13(16):20179-20191. doi: 10.18632/aging.203342. 
      Epub 2021 Aug 10.