PMID- 34380902 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211102 IS - 1673-5374 (Print) IS - 1876-7958 (Electronic) IS - 1673-5374 (Linking) VI - 17 IP - 3 DP - 2022 Mar TI - Assessment of structural brain changes in patients with type 2 diabetes mellitus using the MRI-based brain atrophy and lesion index. PG - 618-624 LID - 10.4103/1673-5374.320996 [doi] AB - Patients with type 2 diabetes mellitus (T2DM) often have cognitive impairment and structural brain abnormalities. The magnetic resonance imaging (MRI)-based brain atrophy and lesion index can be used to evaluate common brain changes and their correlation with cognitive function, and can therefore also be used to reflect whole-brain structural changes related to T2DM. A total of 136 participants (64 men and 72 women, aged 55-86 years) were recruited for our study between January 2014 and December 2016. All participants underwent MRI and Mini-Mental State Examination assessment (including 42 healthy control, 38 T2DM without cognitive impairment, 26 with cognitive impairment but without T2DM, and 30 T2DM with cognitive impairment participants). The total and sub-category brain atrophy and lesion index scores in patients with T2DM with cognitive impairment were higher than those in healthy controls. Differences in the brain atrophy and lesion index of gray matter lesions and subcortical dilated perivascular spaces were found between non-T2DM patients with cognitive impairment and patients with T2DM and cognitive impairment. After adjusting for age, the brain atrophy and lesion index retained its capacity to identify patients with T2DM with cognitive impairment. These findings suggest that the brain atrophy and lesion index, based on T1-weighted and T2-weighted imaging, is of clinical value for identifying patients with T2DM and cognitive impairment. Gray matter lesions and subcortical dilated perivascular spaces may be potential diagnostic markers of T2DM that is complicated by cognitive impairment. This study was approved by the Medical Ethics Committee of University of South China (approval No. USC20131109003) on November 9, 2013, and was retrospectively registered with the Chinese Clinical Trial Registry (registration No. ChiCTR1900024150) on June 27, 2019. FAU - Zhao, Heng AU - Zhao H AD - Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province; Department of Radiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China. FAU - Wang, Fang AU - Wang F AD - Department of Radiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China. FAU - Luo, Guang-Hua AU - Luo GH AD - Department of Radiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China. FAU - Lei, Hao AU - Lei H AD - Department of Radiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China. FAU - Peng, Fei AU - Peng F AD - Department of Radiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China. FAU - Ren, Qiu-Ping AU - Ren QP AD - Department of Radiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China. FAU - Chen, Wei AU - Chen W AD - Department of Radiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China. FAU - Wu, Yan-Fang AU - Wu YF AD - Department of Radiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China. FAU - Yin, Li-Chun AU - Yin LC AD - Department of Radiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China. FAU - Liu, Jin-Cai AU - Liu JC AD - Department of Radiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China. FAU - Pan, Shi-Nong AU - Pan SN AD - Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China. LA - eng PT - Journal Article PL - India TA - Neural Regen Res JT - Neural regeneration research JID - 101316351 PMC - PMC8504365 OTO - NOTNLM OT - Mini-Mental State Examination OT - T1-weighted image OT - T2-weighted image OT - brain atrophy and lesion index OT - cognitive impairments OT - gray matter lesions OT - magnetic resonance imaging OT - structural brain OT - subcortical dilated perivascular spaces OT - type 2 diabetes mellitus COIS- None EDAT- 2021/08/13 06:00 MHDA- 2021/08/13 06:01 PMCR- 2021/08/04 CRDT- 2021/08/12 05:44 PHST- 2021/08/12 05:44 [entrez] PHST- 2021/08/13 06:00 [pubmed] PHST- 2021/08/13 06:01 [medline] PHST- 2021/08/04 00:00 [pmc-release] AID - NeuralRegenRes_2022_17_3_618_320996 [pii] AID - NRR-17-618 [pii] AID - 10.4103/1673-5374.320996 [doi] PST - ppublish SO - Neural Regen Res. 2022 Mar;17(3):618-624. doi: 10.4103/1673-5374.320996.