PMID- 34381318
OWN - NLM
STAT- MEDLINE
DCOM- 20220107
LR  - 20220425
IS  - 1537-744X (Electronic)
IS  - 2356-6140 (Print)
IS  - 1537-744X (Linking)
VI  - 2021
DP  - 2021
TI  - Antifungal Activity of Denture Base Resin Containing Nanozirconia: In Vitro 
      Assessment of Candida albicans Biofilm.
PG  - 5556413
LID - 10.1155/2021/5556413 [doi]
LID - 5556413
AB  - OBJECTIVE: To evaluate the antimicrobial effects of different concentrations of 
      zirconium dioxide nanoparticles (nano-ZrO(2)) reinforcement of poly(methyl) 
      methacrylate (PMMA) on surface roughness and C. albicans biofilm. METHODS: 20 
      heat-polymerized acrylic resin discs were conventionally made and divided into 4 
      groups (n = 5) according to nano-ZrO(2) concentration: control (0% filler) and 3 
      experimental groups (2.5% (Z2.5), 5.0% (Z5.0), and 7.5% (Z7.5)). An optical 
      profilometer was used for surface roughness evaluation, followed by Candida 
      adherence assay. Specimens were sterilized, then immersed in cultured yeast (C. 
      albicans), and incubated at 37 degrees C for 48 hours. After that, discs were rinsed 
      before extracting the clustered pellets of Candida. The attached C. albicans was 
      counted using the direct method after spreading on agar media and incubating for 
      48 hours. Statistical analysis was performed using one-way ANOVA and Tukey's post 
      hoc test at alpha = 0.05. RESULTS: Surface roughness was significantly increased with 
      all modified groups compared with control (P < 0.01), which showed the lowest 
      roughness value (0.027 +/- 0.004 mum). There was no significant difference in the 
      roughness value among reinforced groups (2.5, 5.0, and 7.5%) (P > 0.05), with 
      Z7.5 showing the highest roughness value (0.042 +/- 0.004 mum). Candida count was 
      reduced as the nano-ZrO(2) increased but not significantly (P=0.15). CONCLUSIONS: 
      The addition of different concentrations of nano-ZrO(2) particles to PMMA 
      increased the surface roughness compared with control; in contrast, insignificant 
      reduction of C. albicans biofilm was detected.
CI  - Copyright (c) 2021 Reem Abualsaud et al.
FAU - Abualsaud, Reem
AU  - Abualsaud R
AUID- ORCID: 0000-0001-9435-582X
AD  - Department of Substitutive Dental Sciences, College of Dentistry, Imam 
      Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.
FAU - Aleraky, Doaa M
AU  - Aleraky DM
AUID- ORCID: 0000-0002-4796-0792
AD  - Department of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman 
      Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.
FAU - Akhtar, Sultan
AU  - Akhtar S
AUID- ORCID: 0000-0002-9473-4739
AD  - Department of Biophysics, Institute for Research and Medical Consultations, Imam 
      Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.
FAU - Khan, Soban Q
AU  - Khan SQ
AUID- ORCID: 0000-0002-8573-3080
AD  - Department of Dental Education, College of Dentistry, Imam Abdulrahman Bin Faisal 
      University, P.O. Box 1982, Dammam 31441, Saudi Arabia.
FAU - Gad, Mohammed M
AU  - Gad MM
AUID- ORCID: 0000-0003-3193-2356
AD  - Department of Substitutive Dental Sciences, College of Dentistry, Imam 
      Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20210731
PL  - United States
TA  - ScientificWorldJournal
JT  - TheScientificWorldJournal
JID - 101131163
RN  - 0 (Antifungal Agents)
RN  - 0 (Resins, Synthetic)
RN  - C6V6S92N3C (Zirconium)
RN  - S38N85C5G0 (zirconium oxide)
SB  - IM
MH  - Antifungal Agents/*pharmacology
MH  - Biofilms/drug effects
MH  - Candida albicans/*drug effects
MH  - Denture Bases/*microbiology
MH  - Microscopy, Electron, Scanning
MH  - Nanoparticles
MH  - Resins, Synthetic
MH  - Zirconium/administration & dosage/*pharmacology
PMC - PMC8352684
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2021/08/13 06:00
MHDA- 2022/01/08 06:00
PMCR- 2021/07/31
CRDT- 2021/08/12 06:31
PHST- 2021/01/20 00:00 [received]
PHST- 2021/07/13 00:00 [revised]
PHST- 2021/07/24 00:00 [accepted]
PHST- 2021/08/12 06:31 [entrez]
PHST- 2021/08/13 06:00 [pubmed]
PHST- 2022/01/08 06:00 [medline]
PHST- 2021/07/31 00:00 [pmc-release]
AID - 10.1155/2021/5556413 [doi]
PST - epublish
SO  - ScientificWorldJournal. 2021 Jul 31;2021:5556413. doi: 10.1155/2021/5556413. 
      eCollection 2021.