PMID- 34383046
OWN - NLM
STAT- MEDLINE
DCOM- 20211026
LR  - 20220531
IS  - 1477-9137 (Electronic)
IS  - 0021-9533 (Print)
IS  - 0021-9533 (Linking)
VI  - 134
IP  - 17
DP  - 2021 Sep 1
TI  - Lamin regulates the dietary restriction response via the mTOR pathway in 
      Caenorhabditis elegans.
LID - 10.1242/jcs.258428 [doi]
LID - jcs258428
AB  - Animals subjected to dietary restriction (DR) have reduced body size, low 
      fecundity, slower development, lower fat content and longer life span. We 
      identified lamin as a regulator of multiple dietary restriction phenotypes. 
      Downregulation of lmn-1, the single Caenorhabditis elegans lamin gene, increased 
      animal size and fat content specifically in DR animals. The LMN-1 protein acts in 
      the mTOR pathway, upstream of RAPTOR and S6 kinase beta1 (S6K), a key component of 
      and target of the mechanistic target of rapamycin (mTOR) complex 1 (mTORC1), 
      respectively. DR excludes the mTORC1 activator RAGC-1 from the nucleus. 
      Downregulation of lmn-1 restores RAGC-1 to the nucleus, a necessary step for the 
      activation of the mTOR pathway. These findings further link lamin to metabolic 
      regulation.
CI  - (c) 2021. Published by The Company of Biologists Ltd.
FAU - Charar, Chayki
AU  - Charar C
AUID- ORCID: 0000-0001-6268-2228
AD  - The School of Dental Medicine, The Faculty of Medicine, Tel Aviv University, 
      69978 Tel Aviv, Israel.
AD  - The Alexander Silberman Institute of Life Sciences, The Hebrew University of 
      Jerusalem, 9190401 Jerusalem, Israel.
FAU - Metsuyanim-Cohen, Sally
AU  - Metsuyanim-Cohen S
AD  - The School of Dental Medicine, The Faculty of Medicine, Tel Aviv University, 
      69978 Tel Aviv, Israel.
FAU - Bar, Daniel Z
AU  - Bar DZ
AUID- ORCID: 0000-0003-4074-2802
AD  - The School of Dental Medicine, The Faculty of Medicine, Tel Aviv University, 
      69978 Tel Aviv, Israel.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210906
PL  - England
TA  - J Cell Sci
JT  - Journal of cell science
JID - 0052457
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (LMN-1 protein, C elegans)
RN  - 0 (Laminin)
RN  - 0 (Lamins)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - *Caenorhabditis elegans/genetics
MH  - *Caenorhabditis elegans Proteins/genetics
MH  - Laminin
MH  - Lamins
MH  - Longevity/genetics
MH  - Mechanistic Target of Rapamycin Complex 1/genetics
MH  - TOR Serine-Threonine Kinases/genetics
PMC - PMC8445603
OTO - NOTNLM
OT  - Caenorhabditis elegans
OT  - Dietary restriction
OT  - Lamin
OT  - mTOR
COIS- Competing interests The authors declare no competing or financial interests.
EDAT- 2021/08/13 06:00
MHDA- 2021/10/27 06:00
PMCR- 2021/09/06
CRDT- 2021/08/12 12:27
PHST- 2021/02/04 00:00 [received]
PHST- 2021/07/30 00:00 [accepted]
PHST- 2021/08/13 06:00 [pubmed]
PHST- 2021/10/27 06:00 [medline]
PHST- 2021/08/12 12:27 [entrez]
PHST- 2021/09/06 00:00 [pmc-release]
AID - 272061 [pii]
AID - JCS258428 [pii]
AID - 10.1242/jcs.258428 [doi]
PST - ppublish
SO  - J Cell Sci. 2021 Sep 1;134(17):jcs258428. doi: 10.1242/jcs.258428. Epub 2021 Sep 
      6.