PMID- 34383155
OWN - NLM
STAT- MEDLINE
DCOM- 20220328
LR  - 20220401
IS  - 1612-9067 (Electronic)
IS  - 1612-9059 (Linking)
VI  - 19
IP  - 1
DP  - 2022 Jan
TI  - Impact of preoperative 6-minute walk distance on long-term prognosis after 
      esophagectomy in patients with esophageal cancer.
PG  - 95-104
LID - 10.1007/s10388-021-00871-9 [doi]
AB  - BACKGROUND: The 6-minute walk distance (6MWD) is a simple way of assessing 
      exercise capacity. The purpose of this study was to investigate the relationship 
      between preoperative 6MWD and long-term prognosis after esophagectomy. METHODS: 
      This retrospective cohort study involved 108 patients who underwent radical 
      esophagectomy for esophageal cancer between 2013 and 2020. The patients were 
      classified into the short group (SG: 6MWD < 480 m) or the long group (LG: 6MWD 
       >/=  480 m). To adjust for the background characteristics of both groups, 
      propensity score matching (PSM) analysis was performed and 32 patients were 
      matched from each group. Five-year overall survival (OS) and relapse-free 
      survival (RFS) were analyzed by the Kaplan-Meier method. The log-rank test was 
      used to evaluate differences in survival between the groups. After adjusting for 
      other prognostic factors, the Cox proportional hazards model was used to 
      investigate the impact of preoperative 6MWD on long-term prognosis. RESULTS: The 
      median follow-up period was 923 days. Thirty-three deaths were recorded during 
      the study period. After PSM, 5-year OS following surgery was 29.2 and 66.1% (p 
      = 0.003) and 5-year RFS was 27.9 and 58.6% (p  =  0.021) in the SG and LG, 
      respectively. In Cox proportional hazards analysis, the SG was a significant 
      independent risk factor for OS (hazard ratio 3.33; 95% confidence interval 
      1.37-8.11, p = 0.008) and RFS (hazard ratio 2.30; 95% confidence interval 
      1.08-4.88, p = 0.030). CONCLUSION: The preoperative 6MWD is useful for evaluating 
      exercise capacity and predicting the long-term outcome in patients undergoing 
      esophagectomy.
CI  - (c) 2021. The Japan Esophageal Society.
FAU - Kondo, Shin
AU  - Kondo S
AUID- ORCID: 0000-0001-6985-1565
AD  - Division of Rehabilitation, Tokushima University Hospital, 2-50-1 Kuramoto-cho, 
      Tokushima, 770-8503, Japan. skondo@tokushima-u.ac.jp.
AD  - Department of Public Health, Kobe University Graduate School of Health Sciences, 
      7-10-2 Tomogaoka, Suma-ku, Kobe, 654-0142, Japan. skondo@tokushima-u.ac.jp.
FAU - Inoue, Tatsuro
AU  - Inoue T
AD  - Department of Physical Therapy, Niigata University of Health and Welfare, 1398 
      Shimami-cho, Kita-ku, Niigata-shi, Niigata, 950-3198, Japan.
FAU - Yoshida, Takahiro
AU  - Yoshida T
AD  - Department of Thoracic, Endocrine Surgery and Oncology, Institute of Biomedical 
      Sciences, Tokushima University Graduate School, 3‑18‑15 Kuramoto‑cho, Tokushima, 
      770‑8503, Japan.
FAU - Saito, Takashi
AU  - Saito T
AD  - Department of Public Health, Kobe University Graduate School of Health Sciences, 
      7-10-2 Tomogaoka, Suma-ku, Kobe, 654-0142, Japan.
FAU - Inoue, Seiya
AU  - Inoue S
AD  - Department of Thoracic, Endocrine Surgery and Oncology, Institute of Biomedical 
      Sciences, Tokushima University Graduate School, 3‑18‑15 Kuramoto‑cho, Tokushima, 
      770‑8503, Japan.
FAU - Nishino, Takeshi
AU  - Nishino T
AD  - Department of Thoracic, Endocrine Surgery and Oncology, Institute of Biomedical 
      Sciences, Tokushima University Graduate School, 3‑18‑15 Kuramoto‑cho, Tokushima, 
      770‑8503, Japan.
FAU - Goto, Masakazu
AU  - Goto M
AD  - Department of Thoracic, Endocrine Surgery and Oncology, Institute of Biomedical 
      Sciences, Tokushima University Graduate School, 3‑18‑15 Kuramoto‑cho, Tokushima, 
      770‑8503, Japan.
FAU - Sato, Nori
AU  - Sato N
AD  - Department of Rehabilitation Medicine, Tokushima University Hospital, 2-50-1 
      Kuramoto-cho, Tokushima, 770-8503, Japan.
FAU - Ono, Rei
AU  - Ono R
AD  - Department of Public Health, Kobe University Graduate School of Health Sciences, 
      7-10-2 Tomogaoka, Suma-ku, Kobe, 654-0142, Japan.
FAU - Tangoku, Akira
AU  - Tangoku A
AD  - Department of Thoracic, Endocrine Surgery and Oncology, Institute of Biomedical 
      Sciences, Tokushima University Graduate School, 3‑18‑15 Kuramoto‑cho, Tokushima, 
      770‑8503, Japan.
FAU - Katoh, Shinsuke
AU  - Katoh S
AD  - Department of Rehabilitation Medicine, Tokushima University Hospital, 2-50-1 
      Kuramoto-cho, Tokushima, 770-8503, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210812
PL  - Japan
TA  - Esophagus
JT  - Esophagus : official journal of the Japan Esophageal Society
JID - 101206627
SB  - IM
MH  - *Esophageal Neoplasms/surgery
MH  - *Esophagectomy/methods
MH  - Humans
MH  - Neoplasm Recurrence, Local/surgery
MH  - Prognosis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - 6-minute walk distance
OT  - Esophageal cancer
OT  - Esophagectomy
OT  - Overall survival
OT  - Prognosis
EDAT- 2021/08/13 06:00
MHDA- 2022/03/29 06:00
CRDT- 2021/08/12 12:30
PHST- 2021/02/24 00:00 [received]
PHST- 2021/08/06 00:00 [accepted]
PHST- 2021/08/13 06:00 [pubmed]
PHST- 2022/03/29 06:00 [medline]
PHST- 2021/08/12 12:30 [entrez]
AID - 10.1007/s10388-021-00871-9 [pii]
AID - 10.1007/s10388-021-00871-9 [doi]
PST - ppublish
SO  - Esophagus. 2022 Jan;19(1):95-104. doi: 10.1007/s10388-021-00871-9. Epub 2021 Aug 
      12.