PMID- 34383708
OWN - NLM
STAT- Publisher
LR  - 20240220
IS  - 1588-2640 (Electronic)
IS  - 1217-8950 (Linking)
DP  - 2021 Aug 6
TI  - Fecal microbiota transplantation for recurrent Clostridioides difficile infection 
      in patients with concurrent ulcerative colitis.
LID - 10.1556/030.2021.01498 [doi]
AB  - Treatment of recurrent Clostridioides difficile infection (rCDI) has emerged as 
      an important management dilemma particularly in patients with underlying 
      inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) has been 
      used as a safe and highly effective treatment option for rCDI refractory to 
      standard antibiotic therapies. The aim of this study was to report the efficacy 
      of FMT in Iranian rCDI patients with concurrent IBD. A total of seven consecutive 
      patients with ulcerative colitis (UC) who had experienced 3 episodes of rCDI were 
      enrolled in this study. All patients received at least a single FMT administered 
      during colonoscopy by direct infusion of minimally processed donor stool. 
      Patients were followed for a minimum of 6 months for assessment of treatment 
      efficacy and adverse events (AEs) attributable to FMT. All 7 UC patients (100%) 
      experienced a durable clinical response to a single FMT following 2 months after 
      the procedure. One patient received a second FMT in which a successful resolution 
      of rCDI was ultimately achieved. No serious AEs from FMT were noted. FMT through 
      colonoscopy was a safe, simple and effective alternative treatment approach for 
      rCDI in patients with underlying IBD. However, its use and efficacy should be 
      pursued in long-term prospective controlled trials.
FAU - Gholam-Mostafaei, Fahimeh Sadat
AU  - Gholam-Mostafaei FS
AD  - 1Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, 
      Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti 
      University of Medical Sciences, Tehran, Iran.
FAU - Yadegar, Abbas
AU  - Yadegar A
AUID- ORCID: 0000-0002-2135-7581
AD  - 2Foodborne and Waterborne Diseases Research Center, Research Institute for 
      Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Asadzadeh Aghdaei, Hamid
AU  - Asadzadeh Aghdaei H
AD  - 1Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, 
      Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti 
      University of Medical Sciences, Tehran, Iran.
FAU - Shahrokh, Shabnam
AU  - Shahrokh S
AD  - 3Gastroenterology and Liver Diseases Research Center, Research Institute for 
      Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Ebrahimi Daryani, Nasser
AU  - Ebrahimi Daryani N
AD  - 4Department of Gastroenterology and Hepatology, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Zali, Mohammad Reza
AU  - Zali MR
AD  - 3Gastroenterology and Liver Diseases Research Center, Research Institute for 
      Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20210806
PL  - Hungary
TA  - Acta Microbiol Immunol Hung
JT  - Acta microbiologica et immunologica Hungarica
JID - 9434021
SB  - IM
OTO - NOTNLM
OT  - Clostridioides difficile infection
OT  - diarrhea
OT  - fecal microbiota transplantation
OT  - inflammatory bowel disease
OT  - recurrent infection
EDAT- 2021/08/13 06:00
MHDA- 2021/08/13 06:00
CRDT- 2021/08/12 17:21
PHST- 2021/05/12 00:00 [received]
PHST- 2021/07/28 00:00 [accepted]
PHST- 2021/08/12 17:21 [entrez]
PHST- 2021/08/13 06:00 [pubmed]
PHST- 2021/08/13 06:00 [medline]
AID - 10.1556/030.2021.01498 [doi]
PST - aheadofprint
SO  - Acta Microbiol Immunol Hung. 2021 Aug 6. doi: 10.1556/030.2021.01498.