PMID- 34385064
OWN - NLM
STAT- MEDLINE
DCOM- 20210823
LR  - 20210823
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 223
DP  - 2021 Oct 15
TI  - Environmentally relevant concentrations of tralopyril affect carbohydrate 
      metabolism and lipid metabolism of zebrafish (Danio rerio) by disrupting 
      mitochondrial function.
PG  - 112615
LID - S0147-6513(21)00727-2 [pii]
LID - 10.1016/j.ecoenv.2021.112615 [doi]
AB  - Tralopyril (TP), an antifouling biocide, is widely used to prevent heavy 
      biofouling, and can have potential risks to aquatic organisms. However, there is 
      little information available on the toxicity of tralopyril to aquatic organisms. 
      In this study, the effect of TP on carbohydrate and lipid metabolism, and related 
      mechanisms were evaluated in zebrafish (Danio rerio) larvae. Adverse 
      modifications in carbohydrate metabolism were observed in larvae: hexokinase (HK) 
      activity, succinate dehydrogenase (SDH) activity, and adenosine triphosphate 
      (ATP) content were significantly decreased; and transcript expression of genes 
      (GK, HK1, and PCK1) was also significantly changed. Changes of TG content, FAS 
      activity and transcript expression of genes (ACO, ehhadh, and fas) indicate that 
      TP disrupt lipid metabolism in zebrafish larvae. The change in expression of 
      genes (ndufs4, Sdhalpha, and uqcrc2) involved in the mitochondrial respiratory 
      complexes, and genes (polg1 and tk2) involved in the mitochondrial DNA 
      replication and transcription indicates that these adverse effects on 
      carbohydrate and lipid metabolism are caused by mitochondrial dysfunction.
CI  - Copyright (c) 2021. Published by Elsevier Inc.
FAU - Chen, Xiangguang
AU  - Chen X
AD  - Innovation Center of Pesticide Research, Department of Applied Chemistry, College 
      of Sciences, China Agricultural University, Beijing 100193, China.
FAU - Zheng, Junyue
AU  - Zheng J
AD  - Innovation Center of Pesticide Research, Department of Applied Chemistry, College 
      of Sciences, China Agricultural University, Beijing 100193, China.
FAU - Teng, Miaomiao
AU  - Teng M
AD  - State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese 
      Research Academy of Environmental Sciences, Beijing 100012, China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Innovation Center of Pesticide Research, Department of Applied Chemistry, College 
      of Sciences, China Agricultural University, Beijing 100193, China.
FAU - Qian, Le
AU  - Qian L
AD  - Innovation Center of Pesticide Research, Department of Applied Chemistry, College 
      of Sciences, China Agricultural University, Beijing 100193, China.
FAU - Duan, Manman
AU  - Duan M
AD  - Innovation Center of Pesticide Research, Department of Applied Chemistry, College 
      of Sciences, China Agricultural University, Beijing 100193, China.
FAU - Wang, Zhao
AU  - Wang Z
AD  - The Institute of Plant Production, Jilin Academy of Agriculture Science, 
      Changchun 130033, China.
FAU - Wang, Chengju
AU  - Wang C
AD  - Innovation Center of Pesticide Research, Department of Applied Chemistry, College 
      of Sciences, China Agricultural University, Beijing 100193, China. Electronic 
      address: wangchengju@cau.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210809
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Pyrroles)
RN  - 0 (Water Pollutants, Chemical)
RN  - MEC6MCY7QB 
      (4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile)
SB  - IM
MH  - Animals
MH  - Carbohydrate Metabolism
MH  - Larva
MH  - Lipid Metabolism
MH  - Mitochondria
MH  - Pyrroles
MH  - *Water Pollutants, Chemical/toxicity
MH  - *Zebrafish/genetics
OTO - NOTNLM
OT  - Carbohydrate metabolism
OT  - Lipid metabolism
OT  - Mitochondrial respiratory complexes
OT  - Tralopyril
EDAT- 2021/08/14 06:00
MHDA- 2021/08/24 06:00
CRDT- 2021/08/13 06:06
PHST- 2021/04/19 00:00 [received]
PHST- 2021/08/03 00:00 [revised]
PHST- 2021/08/05 00:00 [accepted]
PHST- 2021/08/14 06:00 [pubmed]
PHST- 2021/08/24 06:00 [medline]
PHST- 2021/08/13 06:06 [entrez]
AID - S0147-6513(21)00727-2 [pii]
AID - 10.1016/j.ecoenv.2021.112615 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2021 Oct 15;223:112615. doi: 
      10.1016/j.ecoenv.2021.112615. Epub 2021 Aug 9.