PMID- 34385566
OWN - NLM
STAT- MEDLINE
DCOM- 20211112
LR  - 20211112
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Aug 12
TI  - WHO grade I meningiomas that show regrowth after gamma knife radiosurgery often 
      show 1p36 loss.
PG  - 16432
LID - 10.1038/s41598-021-95956-x [doi]
LID - 16432
AB  - WHO grade I meningiomas occasionally show regrowth after radiosurgical treatment, 
      which cannot be predicted by clinical features. There is increasing evidence that 
      certain biomarkers are associated with regrowth of meningiomas. The aim of this 
      retrospective study was to asses if these biomarkers could be of value to predict 
      regrowth of WHO grade I meningiomas after additive radiosurgery. Forty-four 
      patients with WHO grade I meningiomas who underwent additive radiosurgical 
      treatment between 2002 and 2015 after Simpson IV resection were included in this 
      study, of which 8 showed regrowth. Median follow-up time was 64 months (range 
      24-137 months). Tumors were analyzed for the proliferation marker Ki-67 by 
      immunohistochemistry and for deletion of 1p36 by fluorescence in situ 
      hybridization (FISH). Furthermore, genomic DNA was analyzed for promoter 
      hypermethylation of the genes NDRG1-4, SFRP1, HOXA9 and MGMT. Comparison of 
      meningiomas with and without regrowth after radiosurgery revealed that loss of 
      1p36 (p = 0.001) and hypermethylation of NDRG1 (p = 0.046) were correlated with 
      regrowth free survival. Loss of 1p36 was the only parameter that was 
      significantly associated with meningioma regrowth after multivariate analysis 
      (p = 0.01). Assessment of 1p36 loss in tumor tissue prior to radiosurgery might 
      be considered an indicator of prognosis/regrowth. However, this finding has to be 
      validated in an independent larger set of tumors.
CI  - (c) 2021. The Author(s).
FAU - Damen, Pim J J
AU  - Damen PJJ
AD  - Department of Pathology, GROW School for Oncology and Developmental Biology, 
      Maastricht University Medical Centre, P. Debyelaan 25, Postbox 5800, 6202 AZ, 
      Maastricht, The Netherlands.
FAU - Bulthuis, Vincent J
AU  - Bulthuis VJ
AD  - Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The 
      Netherlands.
FAU - Hanssens, Patrick E J
AU  - Hanssens PEJ
AD  - Gamma Knife Center Tilburg, ETZ-Elisabeth Hospital, Tilburg, The Netherlands.
FAU - Lie, Suan Te
AU  - Lie ST
AD  - Gamma Knife Center Tilburg, ETZ-Elisabeth Hospital, Tilburg, The Netherlands.
FAU - Fleischeuer, Ruth
AU  - Fleischeuer R
AD  - Department of Pathology, ETZ-Elisabeth Hospital, Tilburg, The Netherlands.
FAU - Melotte, Veerle
AU  - Melotte V
AD  - Department of Pathology, GROW School for Oncology and Developmental Biology, 
      Maastricht University Medical Centre, P. Debyelaan 25, Postbox 5800, 6202 AZ, 
      Maastricht, The Netherlands.
FAU - Wouters, Kim A
AU  - Wouters KA
AD  - Department of Pathology, GROW School for Oncology and Developmental Biology, 
      Maastricht University Medical Centre, P. Debyelaan 25, Postbox 5800, 6202 AZ, 
      Maastricht, The Netherlands.
FAU - Ruland, Andrea
AU  - Ruland A
AD  - Department of Pathology, GROW School for Oncology and Developmental Biology, 
      Maastricht University Medical Centre, P. Debyelaan 25, Postbox 5800, 6202 AZ, 
      Maastricht, The Netherlands.
FAU - Beckervordersandforth, Jan
AU  - Beckervordersandforth J
AD  - Department of Pathology, GROW School for Oncology and Developmental Biology, 
      Maastricht University Medical Centre, P. Debyelaan 25, Postbox 5800, 6202 AZ, 
      Maastricht, The Netherlands.
FAU - Speel, Ernst Jan M
AU  - Speel EJM
AD  - Department of Pathology, GROW School for Oncology and Developmental Biology, 
      Maastricht University Medical Centre, P. Debyelaan 25, Postbox 5800, 6202 AZ, 
      Maastricht, The Netherlands. ernstjan.speel@mumc.nl.
LA  - eng
PT  - Journal Article
DEP - 20210812
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 1
MH  - Female
MH  - Humans
MH  - Male
MH  - Meningeal Neoplasms/*pathology/*radiotherapy
MH  - Meningioma/*pathology/*radiotherapy
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/*pathology
MH  - Radiosurgery/*methods
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Treatment Outcome
MH  - World Health Organization
PMC - PMC8361078
COIS- The authors declare no competing interests.
EDAT- 2021/08/14 06:00
MHDA- 2021/11/16 06:00
PMCR- 2021/08/12
CRDT- 2021/08/13 06:53
PHST- 2021/01/07 00:00 [received]
PHST- 2021/07/21 00:00 [accepted]
PHST- 2021/08/13 06:53 [entrez]
PHST- 2021/08/14 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
PHST- 2021/08/12 00:00 [pmc-release]
AID - 10.1038/s41598-021-95956-x [pii]
AID - 95956 [pii]
AID - 10.1038/s41598-021-95956-x [doi]
PST - epublish
SO  - Sci Rep. 2021 Aug 12;11(1):16432. doi: 10.1038/s41598-021-95956-x.