PMID- 34385597
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20230206
IS  - 1476-5578 (Electronic)
IS  - 1359-4184 (Print)
IS  - 1359-4184 (Linking)
VI  - 26
IP  - 12
DP  - 2021 Dec
TI  - Disrupted intrinsic functional brain topology in patients with major depressive 
      disorder.
PG  - 7363-7371
LID - 10.1038/s41380-021-01247-2 [doi]
AB  - Aberrant topological organization of whole-brain networks has been inconsistently 
      reported in studies of patients with major depressive disorder (MDD), reflecting 
      limited sample sizes. To address this issue, we utilized a big data sample of MDD 
      patients from the REST-meta-MDD Project, including 821 MDD patients and 765 
      normal controls (NCs) from 16 sites. Using the Dosenbach 160 node atlas, we 
      examined whole-brain functional networks and extracted topological features 
      (e.g., global and local efficiency, nodal efficiency, and degree) using graph 
      theory-based methods. Linear mixed-effect models were used for group comparisons 
      to control for site variability; robustness of results was confirmed (e.g., 
      multiple topological parameters, different node definitions, and several head 
      motion control strategies were applied). We found decreased global and local 
      efficiency in patients with MDD compared to NCs. At the nodal level, patients 
      with MDD were characterized by decreased nodal degrees in the somatomotor network 
      (SMN), dorsal attention network (DAN) and visual network (VN) and decreased nodal 
      efficiency in the default mode network (DMN), SMN, DAN, and VN. These topological 
      differences were mostly driven by recurrent MDD patients, rather than 
      first-episode drug naive (FEDN) patients with MDD. In this highly powered 
      multisite study, we observed disrupted topological architecture of functional 
      brain networks in MDD, suggesting both locally and globally decreased efficiency 
      in brain networks.
CI  - (c) 2021. The Author(s).
FAU - Yang, Hong
AU  - Yang H
AD  - Department of Radiology, The First Affiliated Hospital, College of Medicine, 
      Zhejiang University, Hangzhou, Zhejiang, China.
FAU - Chen, Xiao
AU  - Chen X
AD  - CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese 
      Academy of Sciences, Beijing, China.
AD  - Department of Psychology, University of Chinese Academy of Sciences, Beijing, 
      China.
AD  - International Big-Data Center for Depression Research, Institute of Psychology, 
      Chinese Academy of Sciences, Beijing, China.
FAU - Chen, Zuo-Bing
AU  - Chen ZB
AD  - Department of Rehabilitation Medicine, The First Affiliated Hospital, College of 
      Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
FAU - Li, Le
AU  - Li L
AD  - Center for Cognitive Science of Language, Beijing Language and Culture 
      University, Beijing, China.
FAU - Li, Xue-Ying
AU  - Li XY
AD  - CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese 
      Academy of Sciences, Beijing, China.
AD  - Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China.
AD  - Sino-Danish Center for Education and Research, Beijing, China.
FAU - Castellanos, Francisco Xavier
AU  - Castellanos FX
AD  - Department of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, 
      New York, NY, USA.
AD  - Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
FAU - Bai, Tong-Jian
AU  - Bai TJ
AD  - Anhui Medical University, Hefei, Anhui, China.
FAU - Bo, Qi-Jing
AU  - Bo QJ
AD  - Beijing Anding Hospital, Capital Medical University, Beijing, China.
FAU - Cao, Jun
AU  - Cao J
AD  - Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Chang, Zhi-Kai
AU  - Chang ZK
AD  - CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese 
      Academy of Sciences, Beijing, China.
AD  - Department of Psychology, University of Chinese Academy of Sciences, Beijing, 
      China.
FAU - Chen, Guan-Mao
AU  - Chen GM
AD  - The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
FAU - Chen, Ning-Xuan
AU  - Chen NX
AD  - CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese 
      Academy of Sciences, Beijing, China.
AD  - Department of Psychology, University of Chinese Academy of Sciences, Beijing, 
      China.
FAU - Chen, Wei
AU  - Chen W
AD  - Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School 
      of Medicine, Hangzhou, Zhejiang, China.
FAU - Cheng, Chang
AU  - Cheng C
AD  - The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
FAU - Cheng, Yu-Qi
AU  - Cheng YQ
AD  - First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
FAU - Cui, Xi-Long
AU  - Cui XL
AD  - The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
FAU - Duan, Jia
AU  - Duan J
AD  - Department of Psychiatry, First Affiliated Hospital, China Medical University, 
      Shenyang, Liaoning, China.
FAU - Fang, Yiru
AU  - Fang Y
AUID- ORCID: 0000-0002-8748-9085
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
FAU - Gong, Qi-Yong
AU  - Gong QY
AUID- ORCID: 0000-0002-5912-4871
AD  - Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of 
      Sichuan University, Chengdu, Sichuan, China.
AD  - Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, 
      Sichuan, China.
FAU - Guo, Wen-Bin
AU  - Guo WB
AD  - The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
FAU - Hou, Zheng-Hua
AU  - Hou ZH
AD  - Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of 
      Medicine, Southeast University, Nanjing, Jiangsu, China.
FAU - Hu, Lan
AU  - Hu L
AD  - Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Kuang, Li
AU  - Kuang L
AD  - Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Li, Feng
AU  - Li F
AD  - Beijing Anding Hospital, Capital Medical University, Beijing, China.
FAU - Li, Hui-Xian
AU  - Li HX
AD  - CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese 
      Academy of Sciences, Beijing, China.
AD  - Department of Psychology, University of Chinese Academy of Sciences, Beijing, 
      China.
FAU - Li, Kai-Ming
AU  - Li KM
AD  - Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of 
      Sichuan University, Chengdu, Sichuan, China.
FAU - Li, Tao
AU  - Li T
AD  - Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang 
      University School of Medicine, Hangzhou, Zhejiang, China.
AD  - Mental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan 
      University, Chengdu, Sichuan, China.
FAU - Liu, Yan-Song
AU  - Liu YS
AD  - Department of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated 
      Guangji Hospital of Soochow University, Suzhou, Jiangsu, China.
FAU - Liu, Zhe-Ning
AU  - Liu ZN
AD  - The Institute of Mental Health, Second Xiangya Hospital of Central South 
      University, Changsha, Hunan, China.
FAU - Long, Yi-Cheng
AU  - Long YC
AUID- ORCID: 0000-0003-4231-2136
AD  - The Institute of Mental Health, Second Xiangya Hospital of Central South 
      University, Changsha, Hunan, China.
FAU - Lu, Bin
AU  - Lu B
AD  - CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese 
      Academy of Sciences, Beijing, China.
AD  - Department of Psychology, University of Chinese Academy of Sciences, Beijing, 
      China.
FAU - Luo, Qing-Hua
AU  - Luo QH
AD  - Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Meng, Hua-Qing
AU  - Meng HQ
AD  - Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Peng, Daihui
AU  - Peng D
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
FAU - Qiu, Hai-Tang
AU  - Qiu HT
AD  - Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Qiu, Jiang
AU  - Qiu J
AD  - Faculty of Psychology, Southwest University, Chongqing, China.
FAU - Shen, Yue-Di
AU  - Shen YD
AD  - Department of Diagnostics, Affiliated Hospital, Hangzhou Normal University 
      Medical School, Hangzhou, Zhejiang, China.
FAU - Shi, Yu-Shu
AU  - Shi YS
AD  - Department of Radiology, The First Affiliated Hospital, College of Medicine, 
      Zhejiang University, Hangzhou, Zhejiang, China.
FAU - Si, Tian-Mei
AU  - Si TM
AD  - National Clinical Research Center for Mental Disorders (Peking University Sixth 
      Hospital) & Key Laboratory of Mental Health, Ministry of Health (Peking 
      University), Beijing, China.
FAU - Tang, Yan-Qing
AU  - Tang YQ
AD  - Department of Psychiatry, First Affiliated Hospital, China Medical University, 
      Shenyang, Liaoning, China.
FAU - Wang, Chuan-Yue
AU  - Wang CY
AUID- ORCID: 0000-0001-6549-3713
AD  - Beijing Anding Hospital, Capital Medical University, Beijing, China.
FAU - Wang, Fei
AU  - Wang F
AD  - Department of Psychiatry, First Affiliated Hospital, China Medical University, 
      Shenyang, Liaoning, China.
FAU - Wang, Kai
AU  - Wang K
AD  - Anhui Medical University, Hefei, Anhui, China.
FAU - Wang, Li
AU  - Wang L
AD  - National Clinical Research Center for Mental Disorders (Peking University Sixth 
      Hospital) & Key Laboratory of Mental Health, Ministry of Health (Peking 
      University), Beijing, China.
FAU - Wang, Xiang
AU  - Wang X
AUID- ORCID: 0000-0001-9258-2017
AD  - The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
FAU - Wang, Ying
AU  - Wang Y
AUID- ORCID: 0000-0002-0388-4177
AD  - The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
FAU - Wang, Yu-Wei
AU  - Wang YW
AD  - CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese 
      Academy of Sciences, Beijing, China.
AD  - Department of Psychology, University of Chinese Academy of Sciences, Beijing, 
      China.
FAU - Wu, Xiao-Ping
AU  - Wu XP
AD  - Xi'an Central Hospital, Xi'an, Shaanxi, China.
FAU - Wu, Xin-Ran
AU  - Wu XR
AD  - Faculty of Psychology, Southwest University, Chongqing, China.
FAU - Xie, Chun-Ming
AU  - Xie CM
AUID- ORCID: 0000-0002-5978-9689
AD  - Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, 
      Nanjing, Jiangsu, China.
FAU - Xie, Guang-Rong
AU  - Xie GR
AD  - The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
FAU - Xie, Hai-Yan
AU  - Xie HY
AD  - Department of Psychiatry, The Fourth Affiliated Hospital, College of Medicine, 
      Zhejiang University, Yiwu, Zhejiang, China.
FAU - Xie, Peng
AU  - Xie P
AUID- ORCID: 0000-0002-0081-6048
AD  - Institute of Neuroscience, Chongqing Medical University, Chongqing, China.
AD  - Chongqing Key Laboratory of Neurobiology, Chongqing, China.
AD  - Department of Neurology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Xu, Xiu-Feng
AU  - Xu XF
AD  - First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
FAU - Yang, Jian
AU  - Yang J
AD  - Chongqing Key Laboratory of Neurobiology, Chongqing, China.
FAU - Yao, Jia-Shu
AU  - Yao JS
AD  - Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School 
      of Medicine, Hangzhou, Zhejiang, China.
FAU - Yao, Shu-Qiao
AU  - Yao SQ
AD  - The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
FAU - Yin, Ying-Ying
AU  - Yin YY
AD  - Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of 
      Medicine, Southeast University, Nanjing, Jiangsu, China.
FAU - Yuan, Yong-Gui
AU  - Yuan YG
AD  - Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of 
      Medicine, Southeast University, Nanjing, Jiangsu, China.
FAU - Zang, Yu-Feng
AU  - Zang YF
AD  - Center for Cognition and Brain Disorders, Institutes of Psychological Sciences, 
      Hangzhou Normal University, Hangzhou, Zhejiang, China.
AD  - Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, 
      Hangzhou, Zhejiang, China.
FAU - Zhang, Ai-Xia
AU  - Zhang AX
AD  - First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
FAU - Zhang, Hong
AU  - Zhang H
AD  - Xi'an Central Hospital, Xi'an, Shaanxi, China.
FAU - Zhang, Ke-Rang
AU  - Zhang KR
AD  - First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Laboratory of Psychological Health and Imaging, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Zhang, Zhi-Jun
AU  - Zhang ZJ
AUID- ORCID: 0000-0001-5480-0888
AD  - Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, 
      Nanjing, Jiangsu, China.
FAU - Zhao, Jing-Ping
AU  - Zhao JP
AD  - The Institute of Mental Health, Second Xiangya Hospital of Central South 
      University, Changsha, Hunan, China.
FAU - Zhou, Rubai
AU  - Zhou R
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
FAU - Zhou, Yi-Ting
AU  - Zhou YT
AD  - Mental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan 
      University, Chengdu, Sichuan, China.
FAU - Zhu, Jun-Juan
AU  - Zhu JJ
AD  - Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
FAU - Zhu, Zhi-Chen
AU  - Zhu ZC
AD  - CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese 
      Academy of Sciences, Beijing, China.
AD  - Department of Psychology, University of Chinese Academy of Sciences, Beijing, 
      China.
FAU - Zou, Chao-Jie
AU  - Zou CJ
AD  - First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
FAU - Zuo, Xi-Nian
AU  - Zuo XN
AUID- ORCID: 0000-0001-9110-585X
AD  - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern 
      Institute for Brain Research, Beijing Normal University, Beijing, China.
FAU - Yan, Chao-Gan
AU  - Yan CG
AUID- ORCID: 0000-0003-3413-5977
AD  - CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese 
      Academy of Sciences, Beijing, China. ycg.yan@gmail.com.
AD  - Department of Psychology, University of Chinese Academy of Sciences, Beijing, 
      China. ycg.yan@gmail.com.
AD  - International Big-Data Center for Depression Research, Institute of Psychology, 
      Chinese Academy of Sciences, Beijing, China. ycg.yan@gmail.com.
AD  - Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese 
      Academy of Sciences, Beijing, China. ycg.yan@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20210812
PL  - England
TA  - Mol Psychiatry
JT  - Molecular psychiatry
JID - 9607835
SB  - IM
MH  - Brain
MH  - Brain Mapping
MH  - *Depressive Disorder, Major
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Neural Pathways
MH  - Sample Size
PMC - PMC8873016
COIS- The authors declare no competing interests.
EDAT- 2021/08/14 06:00
MHDA- 2022/03/15 06:00
PMCR- 2021/08/12
CRDT- 2021/08/13 06:59
PHST- 2020/11/05 00:00 [received]
PHST- 2021/07/23 00:00 [accepted]
PHST- 2021/07/15 00:00 [revised]
PHST- 2021/08/14 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PHST- 2021/08/13 06:59 [entrez]
PHST- 2021/08/12 00:00 [pmc-release]
AID - 10.1038/s41380-021-01247-2 [pii]
AID - 1247 [pii]
AID - 10.1038/s41380-021-01247-2 [doi]
PST - ppublish
SO  - Mol Psychiatry. 2021 Dec;26(12):7363-7371. doi: 10.1038/s41380-021-01247-2. Epub 
      2021 Aug 12.