PMID- 34385601 OWN - NLM STAT- MEDLINE DCOM- 20220314 LR - 20230207 IS - 1476-5578 (Electronic) IS - 1359-4184 (Linking) VI - 26 IP - 11 DP - 2021 Nov TI - Neurophysiological correlate of incubation of craving in individuals with methamphetamine use disorder. PG - 6198-6208 LID - 10.1038/s41380-021-01252-5 [doi] AB - Previous studies both in laboratory animals and humans have reported that abstinence induces incubation of cue-induced drug craving for nicotine, alcohol, cocaine, and methamphetamine. However, current experimental procedures utilized to study incubation of methamphetamine craving do not incorporate the temporal dynamics of neuropsychological measures and electrophysiological activities associated with this incubation process. This study utilized the high-density electroencephalogram (EEG) signals as a rapid, inexpensive, and noninvasive measure of cue-induced craving potential. A total of 156 male individuals with methamphetamine use disorder (MUD) enrolled in this multisite, cross-sectional study. Structured clinical interview data, self-report questionnaires (cued craving, quality of sleep, impulsivity, anxiety, and depression) and resting-state, eye-closed 128 high-density channel EEG signals were collected at 5 abstinence duration time points (<1, 1-3, 3-6, 6-12, and 12-24 months) to track the neuropsychological and neurophysiological signatures. Cue-induced craving was higher after 1-3 months than after the other time points. This incubation effect was also observed for sleep quality but not for anxiety, depression, and impulsivity symptoms, along with exhibited decreased power spectrum for theta (5.5-8 Hz) and alpha (8-13 Hz), and increased in beta (16.5-26.5 Hz) frequency band. Source reconstructed resting-state EEG analysis showed increased synchronization of medial prefrontal cortex (MPFC) for the beta frequency band in 1-3 months abstinent MUD group, and associated with the incubation of craving. Remarkably, the robust incubation-related abnormalities may be driven by beta-band source space connectivity between MPFC and bilateral orbital gyrus (ORB). Our findings suggest the enhancement of beta activity in the incubation period most likely originates from a dysfunction involving frontal brain regions. This neurophysiological signature of incubation of craving can be used to identify individuals who might be most susceptible to relapse, providing a potential insight into future therapeutic interventions for MUD via neuromodulation of beta activity. CI - (c) 2021. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Zhao, Di AU - Zhao D AUID- ORCID: 0000-0002-6830-8920 AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zhang, Mingming AU - Zhang M AD - Research Center of Brain and Cognitive Neuroscience, Liaoning Normal University, Dalian, Liaoning, China. FAU - Tian, Weiwen AU - Tian W AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Cao, Xinyu AU - Cao X AD - Da Lian Shan Institute of Addiction Rehabilitation, Nanjing, Jiangsu, China. FAU - Yin, Lu AU - Yin L AD - Tian Tang He Institute of Addiction Rehabilitation, Beijing, China. FAU - Liu, Yi AU - Liu Y AD - Tai Hu Institute of Addiction Rehabilitation, Suzhou, Jiangsu, China. FAU - Xu, Tian-Le AU - Xu TL AD - Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - China Center for Brain Science of Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Luo, Wenbo AU - Luo W AUID- ORCID: 0000-0001-8067-6681 AD - Research Center of Brain and Cognitive Neuroscience, Liaoning Normal University, Dalian, Liaoning, China. luowb@lnnu.edu.cn. AD - Key Laboratory of Brain and Cognitive Neuroscience, Dalian, Liaoning Province, China. luowb@lnnu.edu.cn. FAU - Yuan, Ti-Fei AU - Yuan TF AUID- ORCID: 0000-0003-0510-715X AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ytf0707@126.com. AD - Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China. ytf0707@126.com. AD - TianQiao and Chrissy Chen Institute for Translational Research, Shanghai, China. ytf0707@126.com. AD - Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China. ytf0707@126.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210812 PL - England TA - Mol Psychiatry JT - Molecular psychiatry JID - 9607835 RN - 44RAL3456C (Methamphetamine) RN - I5Y540LHVR (Cocaine) SB - IM MH - Animals MH - *Cocaine/pharmacology MH - Craving MH - Cross-Sectional Studies MH - Cues MH - Male MH - *Methamphetamine/pharmacology EDAT- 2021/08/14 06:00 MHDA- 2022/03/15 06:00 CRDT- 2021/08/13 06:59 PHST- 2021/05/31 00:00 [received] PHST- 2021/07/28 00:00 [accepted] PHST- 2021/07/24 00:00 [revised] PHST- 2021/08/14 06:00 [pubmed] PHST- 2022/03/15 06:00 [medline] PHST- 2021/08/13 06:59 [entrez] AID - 10.1038/s41380-021-01252-5 [pii] AID - 10.1038/s41380-021-01252-5 [doi] PST - ppublish SO - Mol Psychiatry. 2021 Nov;26(11):6198-6208. doi: 10.1038/s41380-021-01252-5. Epub 2021 Aug 12.