PMID- 34389477
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20211025
IS  - 1873-2763 (Electronic)
IS  - 1873-2763 (Linking)
VI  - 153
DP  - 2021 Dec
TI  - Development of a bioactive and radiopaque bismuth doped baghdadite ceramic for 
      bone tissue engineering.
PG  - 116147
LID - S8756-3282(21)00313-6 [pii]
LID - 10.1016/j.bone.2021.116147 [doi]
AB  - Baghdadite (Ca(3)ZrSi(2)O(9), BAG), is a Zr-doped calcium silicate that has 
      outstanding bioactivity both in vitro and in vivo. Bioceramic scaffolds should be 
      sufficiently radiopaque to be distinguishable in vivo from surrounding bone 
      structures. To enhance the radiopacity of BAG, this study investigated the effect 
      of incorporating bismuth ions into its crystalline structure 
      (Bi(x)Ca(3-x)ZrSi(2)O(9), x = 0, 0.1, 0.2, 0.5; BAG, Bi0.1-BAG, Bi0.2-BAG, 
      Bi0.5-BAG, respectively). Monophasic baghdadite was retained after bismuth ion 
      incorporation up to x = 0.2 at calcination temperatures of 1350  degrees C. When pressed 
      and sintered, energy dispersive x-ray spectroscopy showed that BAG and Bi0.1-BAG 
      retained crystalline homogeneity, but Bi0.2-BAG formed zirconium-rich crystalline 
      regions. BAG, Bi0.1-BAG and Bi0.2-BAG exhibited non-degradation after 56 days of 
      immersion in culture medium. Bi0.1-BAG exhibited the lowest change in culture 
      medium pH (+0.0), compared to BAG (+0.7) and Bi0.2-BAG (+0.2) after 56 days of 
      culture media immersion. Bi0.1-BAG exhibited similar strength and modulus to BAG 
      (sigma: 200-290 MPa; E: 4-5 GPa), and significantly higher compressive strength and 
      modulus versus Bi0.2-BAG (sigma: 150-200 MPa; E: 3.5-4 GPa) across 56 days of aqueous 
      immersion. In vitro studies using primary human bone derived cells (HOBs) 
      demonstrated a significant increase in HOBs proliferation when cultured on 
      Bi0.1-BAG for seven days compared to BAG and Bi0.2-BAG. Importantly, Bi0.1-BAG 
      showed increased radiopacity by ~33%, when compared to BAG, and by ~115% when 
      compared to biphasic calcium phosphate. The properties of Bi0.1-BAG show promise 
      for its use as a bioactive ceramic with sufficient radiopacity for treatment of 
      bone defects.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - No, Young Jung
AU  - No YJ
AD  - Tissue Engineering & Biomaterials Research Unit, School of Biomedical 
      Engineering, The University of Sydney, NSW 2006, Australia; ARC Training Centre 
      for Innovative BioEngineering, The University of Sydney, NSW 2006, Australia. 
      Electronic address: young.no@sydney.edu.au.
FAU - Nguyen, Tien
AU  - Nguyen T
AD  - Tissue Engineering & Biomaterials Research Unit, School of Biomedical 
      Engineering, The University of Sydney, NSW 2006, Australia; ARC Training Centre 
      for Innovative BioEngineering, The University of Sydney, NSW 2006, Australia.
FAU - Lu, Zufu
AU  - Lu Z
AD  - Tissue Engineering & Biomaterials Research Unit, School of Biomedical 
      Engineering, The University of Sydney, NSW 2006, Australia; ARC Training Centre 
      for Innovative BioEngineering, The University of Sydney, NSW 2006, Australia.
FAU - Mirkhalaf, Mohammad
AU  - Mirkhalaf M
AD  - Tissue Engineering & Biomaterials Research Unit, School of Biomedical 
      Engineering, The University of Sydney, NSW 2006, Australia; ARC Training Centre 
      for Innovative BioEngineering, The University of Sydney, NSW 2006, Australia.
FAU - Fei, Frank
AU  - Fei F
AD  - Tissue Engineering & Biomaterials Research Unit, School of Biomedical 
      Engineering, The University of Sydney, NSW 2006, Australia; ARC Training Centre 
      for Innovative BioEngineering, The University of Sydney, NSW 2006, Australia.
FAU - Foley, Matthew
AU  - Foley M
AD  - Australian Centre for Microscopy & Microanalysis, The University of Sydney, NSW 
      2006, Australia.
FAU - Zreiqat, Hala
AU  - Zreiqat H
AD  - Tissue Engineering & Biomaterials Research Unit, School of Biomedical 
      Engineering, The University of Sydney, NSW 2006, Australia; ARC Training Centre 
      for Innovative BioEngineering, The University of Sydney, NSW 2006, Australia. 
      Electronic address: hala.zreiqat@sydney.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210811
PL  - United States
TA  - Bone
JT  - Bone
JID - 8504048
RN  - 0 (Ca(3)ZrSi(2)O(9))
RN  - 0 (Silicates)
RN  - U015TT5I8H (Bismuth)
SB  - IM
MH  - *Bismuth
MH  - Ceramics
MH  - Compressive Strength
MH  - Humans
MH  - Silicates
MH  - *Tissue Engineering
MH  - Tissue Scaffolds
OTO - NOTNLM
OT  - Bioactive ceramic
OT  - In vitro characterisation
OT  - Radiopacity
OT  - Synthetic bone grafts
EDAT- 2021/08/15 06:00
MHDA- 2021/10/26 06:00
CRDT- 2021/08/14 05:46
PHST- 2021/05/30 00:00 [received]
PHST- 2021/07/27 00:00 [revised]
PHST- 2021/08/06 00:00 [accepted]
PHST- 2021/08/15 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/08/14 05:46 [entrez]
AID - S8756-3282(21)00313-6 [pii]
AID - 10.1016/j.bone.2021.116147 [doi]
PST - ppublish
SO  - Bone. 2021 Dec;153:116147. doi: 10.1016/j.bone.2021.116147. Epub 2021 Aug 11.