PMID- 34390017
OWN - NLM
STAT- MEDLINE
DCOM- 20210908
LR  - 20220716
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 35
IP  - 9
DP  - 2021 Sep
TI  - Distribution and reference interval establishment of neutral-to-lymphocyte ratio 
      (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) 
      in Chinese healthy adults.
PG  - e23935
LID - 10.1002/jcla.23935 [doi]
LID - e23935
AB  - BACKGROUND: Neutral-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio 
      (LMR), and platelet-to-lymphocyte ratio (PLR) are associated with coronavirus 
      disease 2019 (COVID-19) and many diseases, but there are few data about the 
      reference interval (RI) of NLR, LMR, and PLR. METHODS: The neutrophil count, 
      lymphocyte count, monocyte count, and platelet count of 404,272 Chinese healthy 
      adults (>18 years old) were measured by Sysmex XE-2100 automatic hematology 
      analyzer, and NLR, LMR, and PLR were calculated. According to CLSI C28-A3, the 
      nonparametric 95% percentile interval is defined as the reference interval. 
      RESULTS: The results of Mann-Whitney U test showed that NLR (p < .001) in male 
      was significantly higher than that in female; LMR (p < .001) and PLR (p < .001) 
      in male were significantly lower than that in female. Kruskal-Wallis H test 
      showed that there were significant differences in NLR, LMR, and PLR among 
      different genders and age groups (p < .001). The linear graph showed that the 
      reference upper limit of NLR and PLR increased with age and the reference upper 
      limit of LMR decreases with age in male population. In female population, the 
      reference upper limit of NLR in 50-59 group, LMR in >80 group, and PLR in 
      70-79 group appeared a trough; the reference upper limit of NLR in >80 group, LMR 
      in 50-59 group, and PLR in 40-49 group appeared peak. CONCLUSION: The 
      establishment of RI for NLR, LMR, and PLR in Chinese healthy adults according to 
      gender and age will promote the standardization of clinical application.
CI  - (c) 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley 
      Periodicals LLC.
FAU - Wang, Junjun
AU  - Wang J
AUID- ORCID: 0000-0001-7038-2743
AD  - Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, China.
FAU - Zhang, Fan
AU  - Zhang F
AUID- ORCID: 0000-0002-7177-7218
AD  - Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, China.
FAU - Jiang, Feng
AU  - Jiang F
AD  - Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, China.
FAU - Hu, Lijuan
AU  - Hu L
AD  - Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, China.
FAU - Chen, Jian
AU  - Chen J
AD  - Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, China.
FAU - Wang, Yumin
AU  - Wang Y
AUID- ORCID: 0000-0001-8243-3659
AD  - Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, China.
LA  - eng
GR  - Y20180548/Wenzhou Municipal Science and Technology Bureau/
GR  - FHY2019059/Research incubation project at Institute level/
GR  - 81672088/National Natural Science Foundation of China/
GR  - LY19H200002/Natural Science Foundation of Zhejiang Province/
GR  - JBZX-202003/Zhejiang Provincial Research Center for Cancer Intelligent Diagnosis 
      and Molecular Technology/
PT  - Journal Article
DEP - 20210813
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - COVID-19/blood
MH  - China
MH  - Female
MH  - Humans
MH  - Leukocyte Count/*statistics & numerical data
MH  - Lymphocyte Count/*statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - *Monocytes
MH  - *Neutrophils
MH  - Platelet Count/*statistics & numerical data
MH  - Reference Values
MH  - SARS-CoV-2
MH  - Sex Factors
PMC - PMC8418511
OTO - NOTNLM
OT  - lymphocyte-to-monocyte ratio
OT  - neutrophil-to-lymphocyte ratio
OT  - platelet-to-lymphocyte ratio
OT  - reference interval
EDAT- 2021/08/15 06:00
MHDA- 2021/09/09 06:00
PMCR- 2021/08/13
CRDT- 2021/08/14 06:29
PHST- 2021/06/24 00:00 [revised]
PHST- 2021/04/16 00:00 [received]
PHST- 2021/07/20 00:00 [accepted]
PHST- 2021/08/15 06:00 [pubmed]
PHST- 2021/09/09 06:00 [medline]
PHST- 2021/08/14 06:29 [entrez]
PHST- 2021/08/13 00:00 [pmc-release]
AID - JCLA23935 [pii]
AID - 10.1002/jcla.23935 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2021 Sep;35(9):e23935. doi: 10.1002/jcla.23935. Epub 2021 Aug 
      13.