PMID- 34390240
OWN - NLM
STAT- MEDLINE
DCOM- 20220426
LR  - 20220815
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 225
IP  - 3
DP  - 2022 Feb 1
TI  - Human Herpesvirus 6 DNAemia Is Associated With Worse Survival After Ex Vivo 
      T-Cell-Depleted Hematopoietic Cell Transplant.
PG  - 453-464
LID - 10.1093/infdis/jiab412 [doi]
AB  - BACKGROUND: We examined the correlation between persistent human herpesvirus 6 
      (HHV-6) DNAemia (p-HHV-6) and absolute lymphocyte count (ALC), platelet count 
      (PLT), and all-cause mortality by 1 year after ex vivo T-cell-depleted (TCD) 
      hematopoietic cell transplant (HCT). METHODS: We analyzed a cohort of adult TCD 
      HCT recipients during 2012-2016 prospectively monitored for plasma HHV-6 by 
      quantitative polymerase chain reaction from day +14 post-HCT through day +100 
      (D+100). p-HHV-6 was defined as >/=2 consecutive values of >/=500 copies/mL by D+100. 
      PLT and ALC were compared between patients with and without p-HHV-6 using 
      generalized estimating equations (GEE). Multivariable Cox proportional hazard 
      models (PH) were used to identify the impact of p-HHV-6 on 1 year mortality. 
      RESULTS: Of 312 patients, 83 (27%) had p-HHV-6 by D+100. p-HHV-6 was associated 
      with lower ALC and PLT in the first year post-HCT. In multivariable models, 
      p-HHV-6 was associated with higher mortality by 1 year post-HCT (adjusted hazard 
      ratio, 2.97 [95% confidence interval, 1.62-5.47]; P = .0005), after adjusting for 
      age, antiviral treatment, and ALC at D+100. CONCLUSIONS: p-HHV-6 was associated 
      with lower ALC and PLT in the first year post-HCT. p-HHV-6 was an independent 
      predictor of mortality in the first year after TCD HCT.
CI  - (c) The Author(s) 2021. Published by Oxford University Press for the Infectious 
      Diseases Society of America. All rights reserved. For permissions, e-mail: 
      journals.permissions@oup.com.
FAU - Lee, Yeon Joo
AU  - Lee YJ
AUID- ORCID: 0000-0002-2997-0217
AD  - Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering 
      Cancer Center, New York, New York, USA.
AD  - Weill Cornell Medical College, New York, New York, USA.
FAU - Su, Yiqi
AU  - Su Y
AD  - Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering 
      Cancer Center, New York, New York, USA.
FAU - Cho, Christina
AU  - Cho C
AD  - Weill Cornell Medical College, New York, New York, USA.
AD  - Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan 
      Kettering Cancer Center, New York, New York, USA.
FAU - Tamari, Roni
AU  - Tamari R
AD  - Weill Cornell Medical College, New York, New York, USA.
AD  - Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan 
      Kettering Cancer Center, New York, New York, USA.
FAU - Perales, Miguel-Angel
AU  - Perales MA
AD  - Weill Cornell Medical College, New York, New York, USA.
AD  - Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan 
      Kettering Cancer Center, New York, New York, USA.
FAU - Jakubowski, Ann A
AU  - Jakubowski AA
AD  - Weill Cornell Medical College, New York, New York, USA.
AD  - Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan 
      Kettering Cancer Center, New York, New York, USA.
FAU - Papanicolaou, Genovefa A
AU  - Papanicolaou GA
AD  - Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering 
      Cancer Center, New York, New York, USA.
AD  - Weill Cornell Medical College, New York, New York, USA.
LA  - eng
GR  - P01 CA023766/CA/NCI NIH HHS/United States
GR  - P30 CA008748/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - DNA, Viral
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects
MH  - *Herpesvirus 6, Human/genetics
MH  - Humans
MH  - Proportional Hazards Models
MH  - *Roseolovirus Infections
MH  - T-Lymphocytes
MH  - Transplantation, Homologous/adverse effects
PMC - PMC8807153
OTO - NOTNLM
OT  - T-cell depletion
OT  - hematopoietic cell transplant
OT  - human herpesvirus 6
OT  - mortality
EDAT- 2021/08/15 06:00
MHDA- 2022/04/27 06:00
PMCR- 2022/08/14
CRDT- 2021/08/14 08:34
PHST- 2021/04/23 00:00 [received]
PHST- 2021/08/12 00:00 [accepted]
PHST- 2021/08/15 06:00 [pubmed]
PHST- 2022/04/27 06:00 [medline]
PHST- 2021/08/14 08:34 [entrez]
PHST- 2022/08/14 00:00 [pmc-release]
AID - 6352334 [pii]
AID - jiab412 [pii]
AID - 10.1093/infdis/jiab412 [doi]
PST - ppublish
SO  - J Infect Dis. 2022 Feb 1;225(3):453-464. doi: 10.1093/infdis/jiab412.