PMID- 34391828
OWN - NLM
STAT- MEDLINE
DCOM- 20211124
LR  - 20211124
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 179
DP  - 2021 Sep
TI  - Association of statins with mortality in type 2 diabetes patients with intensive 
      glycemic therapy.
PG  - 109005
LID - S0168-8227(21)00364-8 [pii]
LID - 10.1016/j.diabres.2021.109005 [doi]
AB  - AIMS: Intensive glycemic therapy could lead to increased mortality in patients 
      with type 2 diabetes mellitus (T2DM). But it remains unclear whether statins use 
      improves prognosis in T2DM patients with intensive glycemic therapy. METHODS: 
      Using data from Action to Control Cardiovascular Risk in Diabetes trial and 
      performing propensity score matching and Cox proportional hazards regression, we 
      explored the relationship between statin use and the risk of mortality in 
      intensive-therapy group. RESULTS: In the intensive-therapy group, total mortality 
      (TM) in patients with statins treatment is lower than those without statins 
      (hazard ratio (HR), 0.68; 95% confidence interval (CI) 0.49-0.95; P = 0.022); the 
      effects of statins on cardiovascular mortality (CM) and primary outcomes (PO), 
      however, were negligible (CM: HR 0.96; 95% CI 0.61-1.51; P = 0.854; PO: HR 0.88; 
      95% CI 0.65-1.19; P = 0.415). Besides, the risk of TM, CM and PO in patients with 
      the intensive therapy combined with statins use was similar to those in the 
      standard group (TM: P = 0.445; CM: P = 0.362; PO: P = 0.637). CONCLUSIONS: 
      Statins may alleviate the risk of TM in T2DM patients receiving intensive 
      glycemic therapy.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Liao, Longsheng
AU  - Liao L
AD  - Department of Geriatric Medicine, Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
FAU - Liu, Yamei
AU  - Liu Y
AD  - Department of Geriatric Medicine, Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
FAU - Zheng, Chunxiang
AU  - Zheng C
AD  - Department of Geriatric Medicine, Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
FAU - Xiang, Yuan
AU  - Xiang Y
AD  - Department of Geriatric Medicine, Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
FAU - Zhang, Zhe
AU  - Zhang Z
AD  - Department of Genetics and Cell Biology, Basic Medical College, Qingdao 
      University, Qingdao, Shandong, China.
FAU - Cheng, Xunjie
AU  - Cheng X
AD  - Department of Geriatric Medicine, Xiangya Hospital, Central South University, 
      Changsha, Hunan, China; National Clinical Research Center for Geriatric 
      Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China. 
      Electronic address: chengcsu319@csu.edu.cn.
FAU - Bai, Yongping
AU  - Bai Y
AD  - Department of Geriatric Medicine, Xiangya Hospital, Central South University, 
      Changsha, Hunan, China; National Clinical Research Center for Geriatric 
      Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China. 
      Electronic address: baiyongping@csu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210812
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Blood Glucose)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
SB  - IM
MH  - Blood Glucose
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Humans
MH  - *Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
MH  - Risk Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Mortality
OT  - Statins
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/08/16 06:00
MHDA- 2021/11/25 06:00
CRDT- 2021/08/15 20:38
PHST- 2021/01/24 00:00 [received]
PHST- 2021/07/14 00:00 [revised]
PHST- 2021/08/04 00:00 [accepted]
PHST- 2021/08/16 06:00 [pubmed]
PHST- 2021/11/25 06:00 [medline]
PHST- 2021/08/15 20:38 [entrez]
AID - S0168-8227(21)00364-8 [pii]
AID - 10.1016/j.diabres.2021.109005 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2021 Sep;179:109005. doi: 10.1016/j.diabres.2021.109005. 
      Epub 2021 Aug 12.