PMID- 34393486
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220425
IS  - 1176-6336 (Print)
IS  - 1178-203X (Electronic)
IS  - 1176-6336 (Linking)
VI  - 17
DP  - 2021
TI  - To Find Out the Relationship Between Levels of Glycosylated Hemoglobin with 
      Meibomian Gland Dysfunction in Patients with Type 2 Diabetes.
PG  - 797-807
LID - 10.2147/TCRM.S324423 [doi]
AB  - AIM: The aim of this study was to investigate the relationship between levels of 
      glycosylated hemoglobin (HbA1c) with meibomian gland dysfunction (MGD) in 
      patients with type 2 diabetes mellitus (T2DM) and to further explore the related 
      influencing factors. METHODS: Totally, 167 patients with T2DM and 68 non-diabetic 
      subjects were selected. Further, T2DM patients were divided into 2 groups based 
      on 7% HbA1c. Standard patient evaluation of eye dryness (SPEED), lipid layer 
      thickness (LLT), partial blink (PB) ratio, percentage of partial glands (MGP), 
      meibomian gland yielding liquid secretion (MGYLS), meibomian gland yielding 
      secretion score (MGYSS), line of marx (LOM), tear break up time (TBUT), tear 
      meniscus height (TMH) and Schirmer I test (SIT) were applied to evaluate 
      meibomian gland function. Finally, the correlation between HbA1c and various 
      indicators was also analyzed. RESULTS: Between HbA1c>/=7% group and HbA1c<7% group, 
      the differences in LLT (P=0.003), MGP (P<0.001), MGYLS (P=0.014) and TBUT 
      (P=0.015) were all statistically significant. Compared with the non-diabetic 
      group, LLT (P=0.020), MBP (P<0.001), MGYS (P< 0.001), TBUT (P<0.001), SIT 
      (P=0.001), TMH (P=0.017) and LOM (P<0.001) were significantly different in 
      HbA1c>/=7% group, while the differences of MBP (P=0.031), MGYSS (P<0.001), SIT 
      (P=0.001) and LOM (P<0.001) in HbA1c</=7% group were statistically significant. 
      Besides, the prevalence of MGD in HbA1c>/=7% group was evidently higher than that 
      in non-diabetic group (P=0.002). Correlation analysis showed that HbA1c was 
      significantly associated with the LTT and MGP. CONCLUSION: HbA1c>/=7% is likely to 
      result in meibomian gland function dysfunctions in T2DM patients, especially 
      related to LLT and MGP.
CI  - (c) 2021 Fan et al.
FAU - Fan, Fang
AU  - Fan F
AD  - Department of Ophthalmology, Hebei General Hospital, Shijiazhuang, 050051, 
      People's Republic of China.
FAU - Li, Xiaodan
AU  - Li X
AD  - Department of Ophthalmology, Shijiazhuang People's Hospital, Shijiazhuang, 
      050000, People's Republic of China.
FAU - Li, Kejun
AU  - Li K
AD  - Department of Ophthalmology, Hebei General Hospital, Shijiazhuang, 050051, 
      People's Republic of China.
FAU - Jia, Zhiyang
AU  - Jia Z
AD  - Department of Ophthalmology, Hebei General Hospital, Shijiazhuang, 050051, 
      People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20210806
PL  - New Zealand
TA  - Ther Clin Risk Manag
JT  - Therapeutics and clinical risk management
JID - 101253281
PMC - PMC8355550
OTO - NOTNLM
OT  - diabetes mellitus
OT  - glycosylated hemoglobin
OT  - lipid layer thickness
OT  - percentage of partial glands
OT  - type 2 diabetes mellitus
COIS- The authors declare that they have no conflict of interests.
EDAT- 2021/08/17 06:00
MHDA- 2021/08/17 06:01
PMCR- 2021/08/06
CRDT- 2021/08/16 05:43
PHST- 2021/06/11 00:00 [received]
PHST- 2021/07/21 00:00 [accepted]
PHST- 2021/08/16 05:43 [entrez]
PHST- 2021/08/17 06:00 [pubmed]
PHST- 2021/08/17 06:01 [medline]
PHST- 2021/08/06 00:00 [pmc-release]
AID - 324423 [pii]
AID - 10.2147/TCRM.S324423 [doi]
PST - epublish
SO  - Ther Clin Risk Manag. 2021 Aug 6;17:797-807. doi: 10.2147/TCRM.S324423. 
      eCollection 2021.