PMID- 34394079
OWN - NLM
STAT- MEDLINE
DCOM- 20211029
LR  - 20211029
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 12
DP  - 2021
TI  - Immunomodulatory Role and Therapeutic Potential of Non-Coding RNAs Mediated by 
      Dendritic Cells in Autoimmune and Immune Tolerance-Related Diseases.
PG  - 678918
LID - 10.3389/fimmu.2021.678918 [doi]
LID - 678918
AB  - Dendritic cells (DCs) are professional antigen-presenting cells that act as a 
      bridge between innate immunity and adaptive immunity. After activation, DCs 
      differentiate into subtypes with different functions, at which point they 
      upregulate co-stimulatory molecules and produce various cytokines and chemokines. 
      Activated DCs also process antigens for presentation to T cells and regulate the 
      differentiation and function of T cells to modulate the immune state of the body. 
      Non-coding RNAs, RNA transcripts that are unable to encode proteins, not only 
      participate in the pathological mechanisms of autoimmune-related diseases but 
      also regulate the function of immune cells in these diseases. Accumulating 
      evidence suggests that dysregulation of non-coding RNAs contributes to DC 
      differentiation, functions, and so on, consequently producing effects in various 
      autoimmune diseases. In this review, we summarize the main non-coding RNAs 
      (miRNAs, lncRNAs, circRNAs) that regulate DCs in pathological mechanisms and have 
      tremendous potential to give rise to novel therapeutic targets and strategies for 
      multiple autoimmune diseases and immune tolerance-related diseases.
CI  - Copyright (c) 2021 Liu, Wang, Yang, Zheng, Ye and Yang.
FAU - Liu, Yifeng
AU  - Liu Y
AD  - Department of Gastroenterology and Hepatology, Sichuan University-University of 
      Oxford Huaxi Joint Centre for Gastrointestinal Cancer, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Wang, Xiaoze
AU  - Wang X
AD  - Department of Gastroenterology and Hepatology, Sichuan University-University of 
      Oxford Huaxi Joint Centre for Gastrointestinal Cancer, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Yang, Fan
AU  - Yang F
AD  - Department of Gastroenterology and Hepatology, Sichuan University-University of 
      Oxford Huaxi Joint Centre for Gastrointestinal Cancer, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Zheng, Yanyi
AU  - Zheng Y
AD  - Department of Gastroenterology and Hepatology, Sichuan University-University of 
      Oxford Huaxi Joint Centre for Gastrointestinal Cancer, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Ye, Tinghong
AU  - Ye T
AD  - Department of Gastroenterology and Hepatology, Sichuan University-University of 
      Oxford Huaxi Joint Centre for Gastrointestinal Cancer, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Yang, Li
AU  - Yang L
AD  - Department of Gastroenterology and Hepatology, Sichuan University-University of 
      Oxford Huaxi Joint Centre for Gastrointestinal Cancer, West China Hospital, 
      Sichuan University, Chengdu, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210729
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Biomarkers)
RN  - 0 (RNA, Untranslated)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/diagnosis/*etiology/metabolism/therapy
MH  - Biomarkers
MH  - Dendritic Cells/*immunology/*metabolism
MH  - Disease Management
MH  - Disease Susceptibility
MH  - Gene Expression Regulation
MH  - Humans
MH  - Immune Tolerance/*genetics
MH  - Immunomodulation/*genetics
MH  - RNA, Untranslated/*genetics
PMC - PMC8360493
OTO - NOTNLM
OT  - autoimmune disease
OT  - ce-RNAs
OT  - dendritic cell
OT  - immune tolerance
OT  - non-coding RNA
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/08/17 06:00
MHDA- 2021/10/30 06:00
PMCR- 2021/01/01
CRDT- 2021/08/16 05:49
PHST- 2021/03/10 00:00 [received]
PHST- 2021/07/15 00:00 [accepted]
PHST- 2021/08/16 05:49 [entrez]
PHST- 2021/08/17 06:00 [pubmed]
PHST- 2021/10/30 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2021.678918 [doi]
PST - epublish
SO  - Front Immunol. 2021 Jul 29;12:678918. doi: 10.3389/fimmu.2021.678918. eCollection 
      2021.