PMID- 34395204
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220425
IS  - 2229-5151 (Print)
IS  - 2231-5004 (Electronic)
IS  - 2229-5151 (Linking)
VI  - 11
IP  - 2
DP  - 2021 Apr-Jun
TI  - Respiratory mechanics and mortality in coronavirus disease 2019 acute respiratory 
      distress syndrome: A retrospective cohort study.
PG  - 51-55
LID - 10.4103/IJCIIS.IJCIIS_171_20 [doi]
AB  - BACKGROUND: The association between commonly monitored respiratory parameters, 
      including compliance and oxygenation and clinical outcomes in acute respiratory 
      distress syndrome (ARDS) from coronavirus disease 2019 (COVID-19) remains 
      unclear, limiting prognostication and the delivery of targeted treatments. Our 
      project aim was to identify if any such associations exist between clinical 
      outcomes and respiratory parameters. METHODS: We performed a retrospective 
      observational cohort study of confirmed COVID-19 positive patients admitted to a 
      single dedicated intensive care unit at a university hospital from March 27 to 
      April 26, 2020. We collected information on baseline clinical and demographic 
      characteristics and initial respiratory parameters. Our primary outcome was 
      in-hospital mortality. RESULTS: A total of 22 patients met criteria for ARDS and 
      were included in our study. Nine of the 22 (40.9%) patients with ARDS died during 
      hospitalization. The initial static respiratory system compliance of survivors 
      was 39 (interquartile range [IQR] 34, 55) and nonsurvivors was 27 (IQR 24, 33, P 
      < 0.01). A lower respiratory system compliance was associated with an increased 
      adjusted odd of in-hospital mortality (odds ratio 1.2, 95% confidence interval 
      1.01, 1.45 P = 0.04). CONCLUSION: In our cohort of 22 patients mechanically 
      ventilated with ARDS from COVID-19, having lower respiratory system compliance 
      after intubation was associated with an increased risk of in-hospital mortality, 
      consistent with ARDS from non-COVID etiologies.
CI  - Copyright: (c) 2021 International Journal of Critical Illness and Injury Science.
FAU - Gold, Andrew K
AU  - Gold AK
AD  - Department of Anesthesiology and Critical Care Perelman School of Medicine, 
      University of Pennsylvania, Philadelphia, Pennsylvania, USA.
FAU - Scantling, Dane R
AU  - Scantling DR
AD  - Department of Traumatology, Emergency Surgical Services, and Critical Care, 
      Perelman School of Medicine, University of Pennsylvania, Philadelphia, 
      Pennsylvania, USA.
FAU - Brundidge, Dominique A
AU  - Brundidge DA
AD  - Department of Anesthesiology and Critical Care Perelman School of Medicine, 
      University of Pennsylvania, Philadelphia, Pennsylvania, USA.
FAU - Cereda, Maurizio F
AU  - Cereda MF
AD  - Department of Anesthesiology and Critical Care Perelman School of Medicine, 
      University of Pennsylvania, Philadelphia, Pennsylvania, USA.
FAU - Scott, Michael J
AU  - Scott MJ
AD  - Department of Anesthesiology and Critical Care Perelman School of Medicine, 
      University of Pennsylvania, Philadelphia, Pennsylvania, USA.
FAU - Gaulton, Timothy G
AU  - Gaulton TG
AD  - Department of Anesthesiology and Critical Care Perelman School of Medicine, 
      University of Pennsylvania, Philadelphia, Pennsylvania, USA.
LA  - eng
PT  - Journal Article
DEP - 20210629
PL  - India
TA  - Int J Crit Illn Inj Sci
JT  - International journal of critical illness and injury science
JID - 101571136
PMC - PMC8318169
OTO - NOTNLM
OT  - Acute respiratory distress syndrome
OT  - P: F ratio
OT  - berlin criteria
OT  - coronavirus disease 2019
OT  - respiratory compliance
COIS- There are no conflicts of interest.
EDAT- 2021/08/17 06:00
MHDA- 2021/08/17 06:01
PMCR- 2021/04/01
CRDT- 2021/08/16 06:00
PHST- 2020/10/12 00:00 [received]
PHST- 2021/01/30 00:00 [revised]
PHST- 2021/03/16 00:00 [accepted]
PHST- 2021/08/16 06:00 [entrez]
PHST- 2021/08/17 06:00 [pubmed]
PHST- 2021/08/17 06:01 [medline]
PHST- 2021/04/01 00:00 [pmc-release]
AID - IJCIIS-11-51 [pii]
AID - 10.4103/IJCIIS.IJCIIS_171_20 [doi]
PST - ppublish
SO  - Int J Crit Illn Inj Sci. 2021 Apr-Jun;11(2):51-55. doi: 
      10.4103/IJCIIS.IJCIIS_171_20. Epub 2021 Jun 29.