PMID- 34395342
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210817
IS  - 2296-2360 (Print)
IS  - 2296-2360 (Electronic)
IS  - 2296-2360 (Linking)
VI  - 9
DP  - 2021
TI  - Erythema Multiforme Major Associated With Community-Acquired Pneumonia: Lessons 
      From a Case Report.
PG  - 698261
LID - 10.3389/fped.2021.698261 [doi]
LID - 698261
AB  - Background: Erythema multiforme (EM) is an acute immune-mediated inflammatory 
      mucinous skin disorder. The etiology of pediatric EM involves infections, 
      medications, autoimmune diseases, and genetic factors. Case Report: An 8-year-old 
      girl with Mycoplasma pneumoniae (MP) associated community-acquired pneumonia 
      developed erythema target-like symptoms 1 week after azithromycin administration. 
      The erythema quickly spread throughout the body involving the oral and ocular 
      mucous membranes, the trunk, and the extremities, and eventually developed into 
      erythema multiform major (EMM). Through drug withdrawal and specific treatment 
      including systemic corticosteroids and supportive care, her clinical symptoms 
      were improved. After 31 days, most of the mucocutaneous symptoms were relieved, 
      except pigmentation. Human leukocyte antigen (HLA) gene sequencing was performed 
      and 20 HLA genotypes were identified. The patient follow-up lasted for 18 months. 
      Rashes appeared on her trunk when receiving azithromycin orally after discharge 
      and then disappeared after azithromycin withdrawal. Conclusions: Pediatric EM is 
      a rare disease and recognition of its etiology is important for EM management. In 
      this case, azithromycin and HLA-DQB1 (*) 03:01 genotype may contribute to EMM. 
      Lesson: For drug-induced EM, rapid identification and withdrawal of the causative 
      drugs is critical. Re-exposure to the same drug or exposure to drugs with similar 
      chemical structures should also be avoided. Patient education and rational use of 
      medicines are essential for pediatric patients.
CI  - Copyright (c) 2021 Fan, Luo, Lu, Xu, Chen, Guo and Jin.
FAU - Fan, Xiaomei
AU  - Fan X
AD  - Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen, 
      China.
FAU - Luo, Yong
AU  - Luo Y
AD  - Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen, 
      China.
FAU - Lu, Jieluan
AU  - Lu J
AD  - College of Pharmacy, Jinan University, Guangzhou, China.
FAU - Xu, Jinji
AU  - Xu J
AD  - Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen, 
      China.
FAU - Chen, Qing
AU  - Chen Q
AD  - Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen, 
      China.
FAU - Guo, Huijuan
AU  - Guo H
AD  - Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen, 
      China.
FAU - Jin, Ping
AU  - Jin P
AD  - Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen, 
      China.
LA  - eng
PT  - Case Reports
DEP - 20210729
PL  - Switzerland
TA  - Front Pediatr
JT  - Frontiers in pediatrics
JID - 101615492
PMC - PMC8358431
OTO - NOTNLM
OT  - adverse drug reactions
OT  - azithromycin
OT  - children
OT  - erythema multiforme major
OT  - human leukocyte antigen
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/08/17 06:00
MHDA- 2021/08/17 06:01
PMCR- 2021/07/29
CRDT- 2021/08/16 06:01
PHST- 2021/04/21 00:00 [received]
PHST- 2021/07/05 00:00 [accepted]
PHST- 2021/08/16 06:01 [entrez]
PHST- 2021/08/17 06:00 [pubmed]
PHST- 2021/08/17 06:01 [medline]
PHST- 2021/07/29 00:00 [pmc-release]
AID - 10.3389/fped.2021.698261 [doi]
PST - epublish
SO  - Front Pediatr. 2021 Jul 29;9:698261. doi: 10.3389/fped.2021.698261. eCollection 
      2021.